Mostrando 521 - 540 Resultados de 679 Para Buscar 'Ace Lossy~', tiempo de consulta: 2.86s Limitar resultados
  1. 521
    “…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a causative agent of COVID-19 pandemic, enters host cells via the interaction of its Receptor-Binding Domain (RBD) of Spike protein with host Angiotensin-Converting Enzyme 2 (ACE2). Therefore, RBD is a promising vaccine target to induce protective immunity against SARS-CoV-2 infection. …”
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    Development of spike receptor-binding domain nanoparticle as a vaccine candidate against SARS-CoV-2 infection in ferrets
  2. 522
    “…Here, we create a murine model of SARS-CoV-2–induced severe systemic toxicity and multiorgan involvement by expressing the human ACE2 transgene in multiple tissues via viral delivery, followed by systemic administration of SARS-CoV-2. …”
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    Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2–induced systemic toxicity
  3. 523
    “…Various studies recognized the COVID-19 RNA in stool specimens of infected patients, and its viral receptor angiotensin-converting enzyme-2 (ACE-2) is highly expressed in GI epithelial cells. …”
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    Coronavirus (SARS-CoV-2) in gastroenterology and its current epidemiological situation: An updated review until January 2021
  4. 524
    “…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a causative agent of the CoV disease 2019 (COVID-19) pandemic, enters host cells via the interaction of its receptor-binding domain (RBD) of the spike protein with host angiotensin-converting enzyme 2 (ACE2). Therefore, the RBD is a promising vaccine target to induce protective immunity against SARS-CoV-2 infection. …”
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    Online Artículo Texto
    Development of Spike Receptor-Binding Domain Nanoparticles as a Vaccine Candidate against SARS-CoV-2 Infection in Ferrets
  5. 525
    “…In COVID-19 survivors, PPCS presents one or more symptoms: fatigue, dyspnea, memory loss, sleep disorders, and difficulty concentrating. …”
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    Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivors
  6. 526
    “…SARS-CoV-2 cell entry through angiotensin-converting enzyme 2 (ACE2) may enhance the activity of renin–angiotensin–aldosterone system (RAAS) classical axis and further leading to over production of aldosterone. …”
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    How SARS-CoV-2 might affect potassium balance via impairing epithelial sodium channels?
  7. 527
    “…Protection against weight loss and lung pathology was observed with all high-dose vaccines against all viruses. …”
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    Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains
  8. 528
    “…The COVID-19 pandemic led to huge changes to children's daily lives including school closures, loss of contact with family and friends, and financial difficulties which impacted on the wellbeing of all children. …”
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    Child wellbeing in the United Kingdom following the COVID-19 lockdowns
  9. 529
    “…The COVID-19 pandemic has caused devastating loss of life and a healthcare crisis worldwide. SARS-CoV-2 is the causative pathogen of COVID-19 and is transmitted mainly through the respiratory tract, where the virus infects host cells by binding to the ACE2 receptor. …”
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    COVID-19-Related Brain Injury: The Potential Role of Ferroptosis
  10. 530
    por Li, Zhen-lu, Buck, Matthias
    Publicado 2022
    “…Surprisingly, we found that, mutations T547K, H655Y, N764K, N856K, N969K, L981F in the Omicron variant largely enhance the S2: ED1 interaction, partially compensating the loss of S2: ED2 interaction due to the D614G mutation. …”
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    Computational analysis of interior mutations of SARS-CoV-2 Spike protein suggest a balance of protein stability and S2: S1 separation propensity
  11. 531
    “…BACKGROUND: SARS-CoV-2 has been known to cause multisystemic involvement, gaining entry through ACE-2 and TMPRSS2 receptors. COVID-19 vaccine-associated thyroiditis cases are now being reported. …”
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    Thyroiditis after mRNA Vaccination for COVID-19
  12. 532
    por Khurana, Khushi, Singh, Chandra Veer
    Publicado 2022
    “…Therefore, neuroprotective, anti-inflammatory, or depolarizing medications may be helpful for COVID-19 individuals who have lost their sense of smell. According to the available data, we found out olfactory training, topical or oral corticosteroids, caffeine, insulin, or minocycline may effectively treat COVID-19 odor loss. …”
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    Management of Anosmia in COVID-19: A Comprehensive Review
  13. 533
    “…After comparing the LONN models against conventional deep-learning models we observe that our implemented models are less accurate (accuracy loss of about 8%). However, the loss of accuracy is compensated by the fact that LONN models are transparent and safe because the freezing of training parameters makes them less prone to adversarial attacks. …”
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    Medical recommender systems based on continuous-valued logic and multi-criteria decision operators, using interpretable neural networks
  14. 534
    “…Gain and loss of IRF1 function models were established in HEK293T and/or Calu3 cells to evaluate the impact on insulin signaling. …”
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    SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1
  15. 535
    “…Two exceptions were mAb LY-CoV555 monotherapy which lost all protective activity in vivo, and AbbVie 2B04/47D11, which showed partial loss of activity. …”
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    In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains
  16. 536
    “…Body weight loss in K18 mice correlated with the severity of pneumonia, but not with brain infection. …”
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    Endothelial cell infection and dysfunction, immune activation in severe COVID-19
  17. 537
    “…Deforestation is reported to increase susceptibility to COVID-19 due to wildfire induced pollution and loss of forest ecosystem services. Detection of SARS-CoV-2 like viruses in multiple animal species also point to the impacts of biodiversity loss and forest fragmentation in relation to COVID-19. …”
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    Elucidating the role of environmental management of forests, air quality, solid waste and wastewater on the dissemination of SARS-CoV-2
  18. 538
    “…The hmAb 1249A8 emerged as the most potent and broad hmAb, able to recognize all human β-coronavirus and neutralize SARS-CoV and MERS-CoV. 1249A8 demonstrated significant prophylactic activity in K18 hACE2 mice infected with SARS-CoV-2 lineage A and lineage B Beta, and Omicron VoC. 1249A8 delivered as a single 4 mg/kg intranasal (i.n.) dose to hamsters 12 hours following infection with SARS-CoV-2 Delta protected them from weight loss, with therapeutic activity further enhanced when combined with 1213H7, an S1-specific neutralizing hmAb. …”
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    Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody
  19. 539
    “…Furthermore, we evaluated the efficacy of MDB-601a-NM in protecting against SARS-CoV-2 infection using the K18 hACE-2 transgenic mouse model. Mice treated with 60 mg/kg and 100 mg/kg of MDB-601a-NM exhibited improved protectivity in terms of weight loss and survival rates compared to the nafamostat-treated group. …”
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    Evaluation of the Antiviral Efficacy of Subcutaneous Nafamostat Formulated with Glycyrrhizic Acid against SARS-CoV-2 in a Murine Model
  20. 540
    “…The antigenicity of inactivated SARS-CoV-2 was confirmed by ELISA using different Spike-neutralizing monoclonal antibodies. K18-hACE2 mice immunized with inactivated SARS-CoV-2, formulated in AddaS0(3)(TM), presented high neutralizing antibody titers, no significant weight loss, and longer survival than controls from a lethal challenge, despite RNA detection in the oropharyngeal swab, lung, and brain. …”
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    Inactivated and Immunogenic SARS-CoV-2 for Safe Use in Immunoassays and as an Immunization Control for Non-Clinical Trials
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