Mostrando 541 - 560 Resultados de 679 Para Buscar 'Ace Lossy~', tiempo de consulta: 2.33s Limitar resultados
  1. 541
    “…Case Report: We present a case of a 39-year-old male who presented with complaints of generalized fatigue 60, pound weight loss, severe abdominal pain and sensation of lumps in his groin and neck. …”
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    SAT243 A Rare Triad
  2. 542
    “…Saccharomyces cerevisiae Cbk1 kinase is a LATS/NDR tumor suppressor orthologue and component of the Regulation of Ace2 and Morphogenesis signaling network. Cbk1 was previously implicated in regulating polarized morphogenesis, gene expression, and cell integrity. …”
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    Cbk1 kinase and Bck2 control MAP kinase activation and inactivation during heat shock
  3. 543
    “…A reno-protective role for local SDF-1/CXCR4 signaling was indicated by i) CXCR4-dependent glomerular eNOS activation following acute SDF-1 administration; and ii) acceleration of renal function decline, capillary loss and fibrosis in SNx rats treated with chronic CXCR4 blockade. …”
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    SDF-1/CXCR4 Signaling Preserves Microvascular Integrity and Renal Function in Chronic Kidney Disease
  4. 544
    “…In the nigrostriatal system, RAS hyperactivation, via NADPH-oxidase complex activation, exacerbates OS and the microglial inflammatory response and contributes to progression of dopaminergic degeneration, which is inhibited by angiotensin receptor blockers and angiotensin converting enzyme (ACE) inhibitors. Several factors may induce an increase in RAS activity in the dopaminergic system. …”
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    Brain renin-angiotensin system and dopaminergic cell vulnerability
  5. 545
    “…These isolates also harbored virulence factors including the cytolysin toxin genes in ST 4 isolates, as well as multiple biofilm-associated genes (esp, agg, ace, SrtA, gelE, ebpABC), hyaluronidases (hylA, hylB), and other survival genes (ElrA, tpx). …”
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    Characterization of Multi-Drug Resistant Enterococcus faecalis Isolated from Cephalic Recording Chambers in Research Macaques (Macaca spp.)
  6. 546
    “…It binds with high affinity to mu-opioid receptors (MOR), angiotensin-converting enzyme (ACE) and insulin-regulated aminopeptidase (IRAP). …”
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    Molecular insights into the interaction of hemorphin and its targets
  7. 547
    “…Although most COVID-19 patients present with respiratory symptoms, some present with gastrointestinal (GI) symptoms like diarrhoea, loss of appetite, nausea/vomiting and abdominal pain as the major complaints. …”
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    Involvement of digestive system in COVID-19: manifestations, pathology, management and challenges
  8. 548
    por Kreye, Jakob, Reincke, S Momsen, Kornau, Hans-Christian, Sánchez-Sendin, Elisa, Max Corman, Victor, Liu, Hejun, Yuan, Meng, Wu, Nicholas C., Zhu, Xueyong, Lee, Chang-Chun D., Trimpert, Jakob, Höltje, Markus, Dietert, Kristina, Stöffler, Laura, von Wardenburg, Niels, van Hoof, Scott, Homeyer, Marie A, Hoffmann, Julius, Abdelgawad, Azza, Gruber, Achim D, Bertzbach, Luca D, Vladimirova, Daria, Li, Lucie Y, Barthel, Paula Charlotte, Skriner, Karl, Hocke, Andreas C, Hippenstiel, Stefan, Witzenrath, Martin, Suttorp, Norbert, Kurth, Florian, Franke, Christiana, Endres, Matthias, Schmitz, Dietmar, Jeworowski, Lara Maria, Richter, Anja, Schmidt, Marie Luisa, Schwarz, Tatjana, Müller, Marcel Alexander, Drosten, Christian, Wendisch, Daniel, Sander, Leif E, Osterrieder, Nikolaus, Wilson, Ian A, Prüss, Harald
    Publicado 2020
    “…Crystal structures of two mAbs in complex with the SARS-CoV-2 receptor-binding domain at 2.55 and 2.70 Å revealed a direct block of ACE2 attachment. Interestingly, some of the near-germline SARS-CoV-2 neutralizing mAbs reacted with mammalian self-antigens. …”
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    A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model
  9. 549
    “…The D614G mutation significantly enhances SARS-CoV-2 replication on human lung epithelial cells and primary human airway tissues, through an improved infectivity of virions with the spike receptor-binding domain in an “up” conformation for binding to ACE2 receptor. Hamsters infected with D614 or G614 variants developed similar levels of weight loss. …”
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    Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility
  10. 550
    “…The D614G mutation significantly enhances SARS-CoV-2 replication on human lung epithelial cells and primary human airway tissues, through an improved infectivity of virions with the spike receptor-binding domain in an “up” conformation for binding to ACE2 receptor. Hamsters infected with D614 or G614 variants developed similar levels of weight loss. …”
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    Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility
  11. 551
    por Kreye, Jakob, Reincke, S. Momsen, Kornau, Hans-Christian, Sánchez-Sendin, Elisa, Corman, Victor Max, Liu, Hejun, Yuan, Meng, Wu, Nicholas C., Zhu, Xueyong, Lee, Chang-Chun D., Trimpert, Jakob, Höltje, Markus, Dietert, Kristina, Stöffler, Laura, von Wardenburg, Niels, van Hoof, Scott, Homeyer, Marie A., Hoffmann, Julius, Abdelgawad, Azza, Gruber, Achim D., Bertzbach, Luca D., Vladimirova, Daria, Li, Lucie Y., Barthel, Paula Charlotte, Skriner, Karl, Hocke, Andreas C., Hippenstiel, Stefan, Witzenrath, Martin, Suttorp, Norbert, Kurth, Florian, Franke, Christiana, Endres, Matthias, Schmitz, Dietmar, Jeworowski, Lara Maria, Richter, Anja, Schmidt, Marie Luisa, Schwarz, Tatjana, Müller, Marcel Alexander, Drosten, Christian, Wendisch, Daniel, Sander, Leif E., Osterrieder, Nikolaus, Wilson, Ian A., Prüss, Harald
    Publicado 2020
    “…Crystal structures of two mAbs in complex with the SARS-CoV-2 receptor-binding domain at 2.55 and 2.70 Å revealed a direct block of ACE2 attachment. Interestingly, some of the near-germline SARS-CoV-2-neutralizing mAbs reacted with mammalian self-antigens. …”
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    A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model
  12. 552
    “…Cultured pneumocytes express the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor angiotensin-converting enzyme receptor type-2 (ACE2) and can be infected with virus. Transcriptome and histological analysis of infected alveolospheres mirror features of COVID-19 lungs, including emergence of interferon (IFN)-mediated inflammatory responses, loss of surfactant proteins, and apoptosis. …”
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    Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction
  13. 553
    “…Furthermore, baicalein significantly inhibited the body weight loss, the replication of the virus, and relieved the lesions of lung tissue in hACE2 transgenic mice infected with SARS-CoV-2. …”
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    The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro
  14. 554
    “…There are still gaps in the elucidation of the pathways involved in the loss of smell caused by SARS-CoV-2; however, the great affinity of the virus for ACE-2 receptors, which are present in large quantities in the nasal cavity and olfactory bulb, has been considered.…”
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    Anosmia and COVID-19: perspectives on its association and the pathophysiological mechanisms involved
  15. 555
    “…RESULTS: Both human cell receptors ACE2 and TMPRSS2 are essential for the SARS-CoV-2 entrance. …”
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    Pathophysiological relationship between COVID-19 and olfactory dysfunction: A systematic review
  16. 556
    “…Our structure-function analysis revealed that epitopes for RBD-targeting nAbs overlap one another substantially and can be evaded by escape mutants with ACE2 affinities comparable to the wild type, that are observed in sequence surveillance data and infect cells in vitro. …”
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    Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein
  17. 557
    “…SARS-COV-2 has caused millions of deaths in less than one year, yet little is known about the long-term consequences survivors may suffer. …”
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    Development of Diabetes Type 3 After SARS-COV-2 Pancreatic B Cell Injury
  18. 558
    “…Our result showed that the purified RBD immunogen is stable up to 72 h, without any apparent loss in affinity or specificity of interaction with the ACE2 receptor. …”
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    Comparative Immunomodulatory Evaluation of the Receptor Binding Domain of the SARS-CoV-2 Spike Protein; a Potential Vaccine Candidate Which Imparts Potent Humoral and Th1 Type Immune Response in a Mouse Model
  19. 559
    “…This loss-of-function mutation is predicted to alter the free energy dynamics of the transcribed RNA, leading to its instability. …”
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    Saudi Familial Hypercholesterolemia Patients With Rare LDLR Stop Gain Variant Showed Variable Clinical Phenotype and Resistance to Multiple Drug Regimen
  20. 560
    “…Moreover, a single intranasal dose completely protected K18-hACE2 mice from lethal SARS-CoV-2 challenge, preventing weight loss and mortality. …”
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    Single-Dose Intranasal Administration of AdCOVID Elicits Systemic and Mucosal Immunity against SARS-CoV-2 and Fully Protects Mice from Lethal Challenge
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