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601por Huang, Kuan-Ying A., Zhou, Daming, Tan, Tiong Kit, Chen, Charles, Duyvesteyn, Helen M. E., Zhao, Yuguang, Ginn, Helen M., Qin, Ling, Rijal, Pramila, Schimanski, Lisa, Donat, Robert, Harding, Adam, Gilbert-Jaramillo, Javier, James, William, Tree, Julia A., Buttigieg, Karen, Carroll, Miles, Charlton, Sue, Lien, Chia-En, Lin, Meei-Yun, Chen, Cheng-Pin, Cheng, Shu-Hsing, Chen, Xiaorui, Lin, Tzou-Yien, Fry, Elizabeth E., Ren, Jingshan, Ma, Che, Townsend, Alain R., Stuart, David I.“…Neutralization is associated with the inhibition of binding of viral RBD to ACE2 and possibly of the subsequent fusion process. …”
Publicado 2022
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602“…The virus uses the spike protein to target epithelial cells by binding to the ACE2 receptor on the host cells. As a result, effective vaccines must target the viral spike glycoprotein. …”
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603por Routhu, Nanda Kishore, Gangadhara, Sailaja, Lai, Lilin, Davis Gardner, Meredith Elizabeth, Floyd, Katharine, Shiferaw, Ayalnesh, Bartsch, Yannic C, Fischinger, Stephanie, Khoury, Georges, Rahman, Sheikh Abdul, Stampfer, Samuel David, Schaefer, Alexandra, Jean, Sherrie M., Wallace, Chelsea, Stammen, Rachelle L., Wood, Jennifer, Cohen, Joyce, Nagy, Tamas, Parsons, Matthew S., Gralinski, Lisa, Kozlowski, Pamela A., Alter, Galit, Suthar, Mehul S., Amara, Rama Rao“…In contrast, the SL and BU vaccinations induced less spike-specific IgG in secretions and lower levels of polyfunctional IgG in serum compared to IM vaccination. …”
Publicado 2022
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604por Jing, Changqing, Chen, Yuezhi, Shang, Liang, Wang, Jinshen, Lian, Guodong, Tian, Feng, Shao, Yixue, Zhao, Yingnan, Xuan, Jianwei, Li, Leping“…BACKGROUND: Harmonic ACE +7 Shears with Advanced Hemostasis is an upgraded ultrasonic device, an ultrasonic surgical and electrosurgical system (USES). …”
Publicado 2022
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605por Jeong, Gi Uk, Lyu, Jaemyun, Kim, Kyun-Do, Chung, Young Cheul, Yoon, Gun Young, Lee, Sumin, Hwang, Insu, Shin, Won-Ho, Ko, Junsu, Lee, June-Yong, Kwon, Young-Chan“…After this proinflammatory activation, SARS-CoV-2 infection promoted both intrinsic and extrinsic death receptor-mediated apoptosis in HMC3. Using K18-hACE2 transgenic mice, murine microglia were also infected by intranasal inoculation of SARS-CoV-2. …”
Publicado 2022
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606por Pickl, Christoph, Engelmann, Simon, Girtner, Florian, Gužvić, Miodrag, van Rhijn, Bas W. G., Hartmann, Valerie, Holbach, Sonja, Kälble, Sebastian, Haas, Maximilian, Rosenhammer, Bernd, Breyer, Johannes, Burger, Maximilian, Mayr, Roman“…We were able to demonstrate that loss of skeletal muscle mass is a significant comorbidity-independent risk factor. …”
Publicado 2023
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607por Smirnova, Olga A., Ivanova, Olga N., Fedyakina, Irina T., Yusubalieva, Gaukhar M., Baklaushev, Vladimir P., Yanvarev, Dmitry V., Kechko, Olga I., Mitkevich, Vladimir A., Vorobyev, Pavel O., Fedorov, Vyacheslav S., Bartosch, Birke, Valuev-Elliston, Vladimir T., Lipatova, Anastasiya L., Ivanov, Alexander V.“…The virus can induce not only a cytokine storm and thrombosis but also various extra-respiratory diseases such as liver dysfunction, strong headaches, loss of smell and even psychiatric disorders. However, information on whether SARS-CoV-2 can infect liver or brain tissues is still contradictory. …”
Publicado 2023
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608por Acharya, Arpan, Ambikan, Anoop T, Thurman, Michellie, Malik, Mohid Reza, Dyavar, Shetty Ravi, Végvári, Ákos, Neogi, Ujjwal, Byrareddy, Siddappa N“…Majority of patients with PASC develop neurological disorders like brain fog, fatigue, mood swings, sleep disorders, loss of smell and test among others collectively called neuro-PASC. …”
Publicado 2023
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609“…CSF analysis showed elevated CSF protein and ACE levels. Visual field testing revealed bitemporal hemianopsia. …”
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610por Ferreira, Ana, Bastos, Filipa, Nunes da Silva, Tiago, Cordeiro, Maria, Portugal, Jorge“…Clinical case: a 44 year-old woman presented to the emergency room with a 3-months history of bilateral vision loss. She also complained of galactorrhea, oligomenorrhea, polydipsia (drinking 5L of water a day), polyuria and nocturia. …”
Publicado 2019
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611por Siddique, Faisal, Abbas, Rao Zahid, Mansoor, Muhammad Khalid, Alghamdi, Etab Saleh, Saeed, Muhammad, Ayaz, Muhammad Mazhar, Rahman, Moazur, Mahmood, Muhammad Shahid, Iqbal, Asif, Manzoor, Maida, Abbas, Asghar, Javaid, Asif, Hussain, Irshad“…SARS-CoV-2 penetrates the host cell via binding its spike protein to the angiotensin-converting enzyme 2 (ACE2) receptor, which is similar to the mechanisms of SARS-CoV and MERS-CoV. …”
Publicado 2021
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612por Cho, Hyeseon, Gonzales-Wartz, Kristina Kay, Huang, Deli, Yuan, Meng, Peterson, Mary, Liang, Janie, Beutler, Nathan, Torres, Jonathan L., Cong, Yu, Postnikova, Elena, Bangaru, Sandhya, Talana, Chloe Adrienna, Shi, Wei, Yang, Eun Sung, Zhang, Yi, Leung, Kwanyee, Wang, Lingshu, Peng, Linghang, Skinner, Jeff, Li, Shanping, Wu, Nicholas C., Liu, Hejun, Dacon, Cherrelle, Moyer, Thomas, Cohen, Melanie, Zhao, Ming, Lee, F. Eun-Hyung, Weinberg, Rona S., Douagi, Iyadh, Gross, Robin, Schmaljohn, Connie, Pegu, Amarendra, Mascola, John R., Holbrook, Michael, Nemazee, David, Rogers, Thomas F., Ward, Andrew B., Wilson, Ian A., Crompton, Peter D., Tan, Joshua“…The crystal structure of the most potent antibody, CV503, revealed that it binds to the ridge region of SARS-CoV-2 RBD, competes with the ACE2 receptor, and has limited contact with key variant residues K417, E484 and N501. …”
Publicado 2021
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613por Chan, Conrad E. Z., Seah, Shirley G. K., Chye, De Hoe, Massey, Shane, Torres, Maricela, Lim, Angeline P. C., Wong, Steven K. K., Neo, Jacklyn J. Y., Wong, Pui San, Lim, Jie Hui, Loh, Gary S. L., Wang, Dongling, Boyd-Kirkup, Jerome D., Guan, Siyu, Thakkar, Dipti, Teo, Guo Hui, Purushotorman, Kiren, Hutchinson, Paul E., Young, Barnaby E., Low, Jenny G., MacAry, Paul A., Hentze, Hannes, Prativadibhayankara, Venkateshan S., Ethirajulu, Kantharaj, Comer, Jason E., Tseng, Chien-Te K., Barrett, Alan D. T., Ingram, Piers J., Brasel, Trevor, Hanson, Brendon John“…In SARS-CoV-2-infected hamsters, SC31 treatment significantly prevented weight loss, reduced viral loads, and attenuated the histopathology of the lungs. …”
Publicado 2021
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614por Borin, Alexandre, Coimbra, Laís D., Bispo-dos-Santos, Karina, Naciuk, Fabrício F., Fontoura, Marina, Simeoni, Camila L., Gomes, Giovanni V., Amorim, Mariene R., Gravina, Humberto D., Shimizu, Jacqueline Farinha, Passos, Amanda S. C., de Oliveira, Isadora M., de Carvalho, Ana Carolina, Cardoso, Alisson Campos, Parise, Pierina L., Toledo-Teixeira, Daniel A., Sotorilli, Giuliana E., Persinoti, Gabriela F., Claro, Ingra Morales, Sabino, Ester C., Alborghetti, Marcos R., Rocco, Silvana A., Franchini, Kleber G., de Souza, William M., Oliveira, Paulo S. L., Cunha, Thiago M., Granja, Fabiana, Proença-Módena, José Luiz, Trivella, Daniela B.B., Bruder, Marjorie, Cordeiro, Artur T., Marques, Rafael Elias“…The ongoing COVID-19 pandemic caused a significant loss of human lives and a worldwide decline in quality of life. …”
Publicado 2022
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615“…She had low PTHrp, normal ACE level, and negative TB testing. Pre-pregnancy calcium was normal (9.8mg/dl). …”
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616por Rodriguez, Lauren, Li, Jiani, Han, Dong, Martin, Ross, Moshiri, Jasmine, Peinovich, Nadine, Bilello, John P, Perry, Jason K, Hedskog, Charlotte“…Phenotyping of individual substitutions using SDMs showed no loss of RDV or ODV susceptibility (< 1.2-fold change in EC(50) vs WA1). …”
Publicado 2023
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617por McGrath, Jonathan, Kenny, Claire, Nielsen, Charlotte Salgaard, Domegan, Lisa, Walsh, Cathal, Rooney, Peadar, Walsh, Shane, Conlon, Niall, Brady, Gareth, Ibrahim, Aya, Dunne, Jean, McCormack, William, Corcoran, Niamh, Allen, Niamh, Fleming, Catherine, Bergin, Colm“…Antibody neutralisation capacity was assessed in a subset of samples via an in vitro ACE2 binding enzyme-linked immunosorbent assay. …”
Publicado 2023
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618por Ardanuy, Jeremy, Johnson, Robert, Dillen, Carly, Taylor, Louis, Hammond, Holly, Weston, Stuart, Frieman, Matthew“…In our studies, pyronaridine treatment resulted in significant improvements to lung inflammatory pathology, reducing pro-inflammatory cytokine and chemokine levels, and inhibiting weight loss seen in the mouse model associated with the severity of disease in three highly pathogenic coronavirus infection models, SARS-CoV-1, SARS-CoV-2, and MERS-CoV. …”
Publicado 2023
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619“…EBUS with mediastinal lymph node biopsy was non-diagnostic, however, excisional biopsy of mediastinal node showed non-caseating granuloma. ACE level, flow cytometry, infectious work up and serum IgG4 were normal. …”
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620por Swami, Janya“…Sarcoidosis most frequently affects the lungs, but in upto 30% of cases, can present with extrapulmonary manifestations. Less than 10% of patients with sarcoidosis present with disease at extrapulmonary sites. 10%-20% patients with sarcoidosis present with hypercalcemia. …”
Publicado 2020
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