Mostrando 61 - 80 Resultados de 679 Para Buscar 'Ace Lossy~', tiempo de consulta: 1.87s Limitar resultados
  1. 61
    “…Here, we report humanized ACE2-floxed mice in which hACE2 is expressed from the mouse Ace2 locus in a manner that confers lethal disease and permits cell-specific, Cre-mediated loss of function, and LSL-hACE2 mice in which hACE2 is expressed from the Rosa26 locus enabling cell-specific, Cre-mediated gain of function. …”
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    Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection
  2. 62
    “…These data indicate an age-related dysregulation of brain RAS is likely to be driven by a reduction in ACE-2. The reduction in ACE-2 occurs at a young age, coinciding with early pathological changes and the initial deposition of Aβ, and preceding neuronal loss and cognitive decline, in the transgenic AD models. …”
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    Age-related reduction in brain ACE-2 is not exacerbated by Alzheimer’s disease pathology in mouse models of Alzheimer’s disease
  3. 63
    “…We hypothesized that loss of ACE2 would facilitate Ang II-mediated vascular inflammation and peroxynitrite production. 10-week wildtype (WT, Ace2(+/y)) and ACE2 knockout (ACE2KO, Ace2(−/y)) mice received with mini-osmotic pumps with Ang II (1.5 mg.kg(−1).d(−1)) or saline for 2 weeks. …”
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    ACE2 Deficiency Enhances Angiotensin II-Mediated Aortic Profilin-1 Expression, Inflammation and Peroxynitrite Production
  4. 64
    por Gab-Alla, Amr A.
    Publicado 2021
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    SmartSurf(ACE) transepithelial photorefractive keratectomy with mitomycin C enhancement after small incision lenticule extraction
  5. 65
    “…The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in tremendous loss worldwide. Although viral spike (S) protein binding of angiotensin-converting enzyme 2 (ACE2) has been established, the functional consequences of the initial receptor binding and the stepwise fusion process are not clear. …”
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    SARS-CoV-2 spike engagement of ACE2 primes S2′ site cleavage and fusion initiation
  6. 66
    “…Loss of ACE2 resulted in decreased weight gain but increased glucose intolerance, epicardial adipose tissue (EAT) inflammation, and polarization of macrophages into a proinflammatory phenotype in response to HFD. …”
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    ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity
  7. 67
    “…Moreover, by using the Barnes classification, we noted an overall loss of interfacial interactions (with gain of new interactions in certain cases) at the receptor-binding domain (RBD) mediated by substituted residues for neutralizing complexes in classes 1 and 2, whereas less destabilization was observed for classes 3 and 4. …”
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    Modeling of ACE2 and antibodies bound to SARS-CoV-2 provides insights into infectivity and immune evasion
  8. 68
    “…RNA-Seq and histological analyses illustrated that this model involved an acute inflammatory disease followed by resolution and tissue repair, with a transcriptomic profile similar to that seen in COVID-19 patients. hACE2-lentivirus transduction of IFNAR(-/-) and IL-28RA(-/-) mouse lungs was used to illustrate that loss of type I or III interferon responses have no significant effect on virus replication. …”
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    ACE2-lentiviral transduction enables mouse SARS-CoV-2 infection and mapping of receptor interactions
  9. 69
    “…Moreover, all modifications were stably transferred during germline transmission. In Ace2-knockout male mice (Ace2 (−/y)), we observed severe chemical induced colitis, characterized by considerable weight loss, diarrhea and a shortened colon length. …”
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    Generation of outbred Ace2 knockout mice by RNA transfection of TALENs displaying colitis reminiscent pathophysiology and inflammation
  10. 70
    “…Loss of catalytic activity reduced the decoy's therapeutic efficacy, which was further confirmed by intravenous administration, supporting dual mechanisms of action: direct blocking of S and turnover of ACE2 substrates associated with lung injury and inflammation. …”
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    An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV‐2
  11. 71
    “…The COVID‐19 pandemic caused by SARS‐CoV‐2 infection has led to socio‐economic shutdowns and the loss of over 5 million lives worldwide. There is a need for the identification of therapeutic targets to treat COVID‐19. …”
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    Insect cell expression and purification of recombinant SARS‐COV‐2 spike proteins that demonstrate ACE2 binding
  12. 72
    “…Molecular dynamics simulation of RBD/ACE2 in the presence BAZ resulted in loss of contact and specific hydrogen-bond interaction required for RBD/ACE2 stability. …”
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    Benzimidazole compound abrogates SARS-COV-2 receptor-binding domain (RBD)/ACE2 interaction In vitro
  13. 73
    “…Intranasal SARS-CoV-2 inoculation in hACE2-LoxP(STOP)×UBC-Cre offspring resulted in weight loss and death in 6 out of 8 mice. …”
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    The Tissue Distribution of SARS-CoV-2 in Transgenic Mice With Inducible Ubiquitous Expression of hACE2
  14. 74
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    Endothelial Glycocalyx of Peritubular Capillaries in Experimental Diabetic Nephropathy: A Target of ACE Inhibitor-Induced Kidney Microvascular Protection
  15. 75
    “…In the present study, we established an animal model highly susceptible to SARS-CoV-2 via the intratracheal tract infection in CAG promoter–driven human angiotensin-converting enzyme 2–transgenic (CAG-hACE2) mice. The CAG-hACE2 mice showed several severe symptoms of SARS-CoV-2 infection, with definitive weight loss and subsequent death. …”
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    Highly susceptible SARS-CoV-2 model in CAG promoter–driven hACE2-transgenic mice
  16. 76
    “…Lemon extract (LE) has been proposed to improve serum insulin levels and decrease angiotensin converting enzyme (ACE) activity in mouse models. ACE is also a biomarker for sustained weight loss and ACE inhibitors improve insulin sensitivity in humans. …”
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    Lemon Extract Reduces Angiotensin Converting Enzyme (ACE) Expression and Activity and Increases Insulin Sensitivity and Lipolysis in Mouse Adipocytes
  17. 77
    “…Previously, we have shown that loss of angiotensin-I converting enzyme 2 (ACE2) promotes the ACE/angiotensin-II (Ang-II)/angiotensin type 1 receptor (AT1R) axis, a deleterious arm of RAS, unleashing its detrimental effects in diabetes. …”
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    SARS-CoV-2 Infections and ACE2: Clinical Outcomes Linked With Increased Morbidity and Mortality in Individuals With Diabetes
  18. 78
    “…BACKGROUND: Diastolic dysfunction develops in response to hypertension and estrogen (E2) loss and is a forerunner to heart failure (HF) in women. …”
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    Blunting of cardioprotective actions of estrogen in female rodent heart linked to altered expression of cardiac tissue chymase and ACE2
  19. 79
    “…Given the requirement of angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 entry into host cells, here we discuss how the downregulation of ACE2 in the COVID-19 patients and virus-induced shift in ACE2 catalytic equilibrium, change the concentrations of substrates such as angiotensin II, apelin-13, dynorphin-13, and products such as angiotensin (1–7), angiotensin (1–9), apelin-12, dynorphin-12 in the human body. …”
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    Induced dysregulation of ACE2 by SARS-CoV-2 plays a key role in COVID-19 severity
  20. 80
    “…The exercise group, the Group Aged Care Exercise (GrACE) programme, performed 12 weeks of twice weekly resistance exercises. …”
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    Feasibility and benefits of group-based exercise in residential aged care adults: a pilot study for the GrACE programme
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