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  1. 1981
    “…Moreover, Kir4.1 channels act as novel modulators of the expression of brain-derived neurotrophic factor (BDNF) in astrocytes. …”
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    Emerging Roles of Astrocyte Kir4.1 Channels in the Pathogenesis and Treatment of Brain Diseases
  2. 1982
    “…We revealed that LINC01615 is regulated by the transcription factor SIPA1 in promoting breast cancer cell malignancy. ABSTRACT: Long non-coding RNAs (lncRNAs) are reported to play an important regulatory effect in carcinogenesis and malignancy. …”
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    SIPA1 Regulates LINC01615 to Promote Metastasis in Triple-Negative Breast Cancer
  3. 1983
    por Mahapatra, Kalyan, Roy, Sujit
    Publicado 2021
    “…The plant-specific NAC domain family transcription factor SOG1 (SUPPRESSOR OF GAMMA RESPONSE 1) plays crucial role in transducing signals from both ATM and ATR in presence of double strand breaks (DSBs) in the genome and found to play crucial role in the regulation of key genes involved in cell cycle progression, DNA damage repair, endoreduplication and programmed cell death. …”
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    SOG1 transcription factor promotes the onset of endoreduplication under salinity stress in Arabidopsis
  4. 1984
    por Zhang, Yan, Chen, Zhixiang
    Publicado 2020
    “…In mammalian cells, two structurally related proteins p62 and NBR1 act as cargo receptors for selective autophagy of ubiquitinated proteins including aggregation-prone proteins in aggrephagy. …”
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    Broad and Complex Roles of NBR1-Mediated Selective Autophagy in Plant Stress Responses
  5. 1985
    “…Neutrophils play an essential role in the innate immune defense system in vertebrates. …”
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    Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb
  6. 1986
    “…BACKGROUND: Actin filament-associated protein 1-antisense RNA 1 (AFAP1-AS1) plays an important role in the development and progression of several human cancers. …”
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    Long Noncoding RNA AFAP1-AS1 Promotes Cell Proliferation and Metastasis via the miR-155-5p/FGF7 Axis and Predicts Poor Prognosis in Gastric Cancer
  7. 1987
    “…The two genes were found to largely act additively in regulating HD and yield traits. …”
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    Effects of Hd2 in the presence of the photoperiod-insensitive functional allele of Hd1 in rice
  8. 1988
    “…In conclusion, SDF2L1 may act as a cancer suppressor gene, play a crucial role in the occurrence and development of NPC, and be a new therapeutic target or prognostic indicator for NPC.…”
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    SDF2L1 Inhibits Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma
  9. 1989
    “…In addition, GPBAR-1 acts on pathways involved in inflammation, biliary epithelial barrier permeability, BA pool hydrophobicity, and sinusoidal blood flow. …”
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    Bile Acids and GPBAR-1: Dynamic Interaction Involving Genes, Environment and Gut Microbiome
  10. 1990
    “…BACKGROUND: Chemokine (C-C motif) ligand 1 (CCL1) is produced by activated monocytes/ macrophages and T-lymphocytes, and acts as a potent attractant for Th2 cells and a subset of T-regulatory (Treg) cells. …”
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    The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis
  11. 1991
    “…We previously found that KCa3.1 trafficking and gating require calmodulin (CaM) binding, and this is inhibited by cAMP kinase (PKA) acting at a single phosphorylation site. …”
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    KCa3.1/IK1 Channel Regulation by cGMP-Dependent Protein Kinase (PKG) via Reactive Oxygen Species and CaMKII in Microglia: An Immune Modulating Feedback System?
  12. 1992
    “…Enoyl-acyl carrier protein reductases (FabI) play a crucial role in lipids and fatty acid biosynthesis, which are essential for the integrity of the bacterial cell membrane. …”
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    Molecular Modelling Study and Antibacterial Evaluation of Diphenylmethane Derivatives as Potential FabI Inhibitors
  13. 1993
    “…Endothelial cells play an important role in sensing danger signals and regulating inflammation. …”
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    Cooperation of Complement MASP-1 with Other Proinflammatory Factors to Enhance the Activation of Endothelial Cells
  14. 1994
    por Cho, Hyeseon, Kehrl, John H.
    Publicado 2007
    “…We show expression of G(iα1), G(iα2), and G(iα3) in the centrosomes and at the midbody. …”
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    Localization of G(iα) proteins in the centrosomes and at the midbody: implication for their role in cell division
  15. 1995
    “…Using an endonuclease-coupled DNA methylation assay, we identified two anthraquinone compounds, each containing an aromatic substituent, that act as direct DNMT1 inhibitors. These simplified anthraquinone compounds retain the DNA-competitive mechanism of action of LCA and exhibit some selectivity for DNMT1 over DNMT3a. …”
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    Substituted anthraquinones represent a potential scaffold for DNA methyltransferase 1-specific inhibitors
  16. 1996
    “…Regucalcin (RGN) plays multiple regulatory roles in intracellular Ca(2+) signaling pathways in mammalian cells. …”
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    Regucalcin enhances adipocyte differentiation and attenuates inflammation in 3T3‐L1 cells
  17. 1997
    “…Sphingosine kinase 1 (SPHK1), an ATP-dependent protein, has previously been demonstrated to be upregulated in several types of human cancer and to play an important role in tumor development and progression. …”
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    Upregulation of sphingosine kinase 1 is associated with recurrence and poor prognosis in papillary thyroid carcinoma
  18. 1998
    “…Serine protease inhibitors (SERPINs) are a superfamily of highly conserved proteins that play a key role in controlling the activity of proteases in diverse biological processes. …”
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    SERPINA2 Is a Novel Gene with a Divergent Function from SERPINA1
  19. 1999
    “…S1P can act either intracellularly or extracellularly through specific ligation to its five G protein-coupled receptors (GPCR) named S1P receptors (S1PR). …”
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    Sphingosine 1-phosphate axis: a new leader actor in skeletal muscle biology
  20. 2000
    “…Adipose tissue development and function play a critical role in the regulation of energy balance, lipid metabolism, and the pathophysiology of metabolic syndromes. …”
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    Zinc-chelated Vitamin C Stimulates Adipogenesis of 3T3-L1 Cells
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