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  1. 2021
    “…Due to their ability to act as photoswitches, these proteins are considered as ideal candidates for applications such as optogenetics. …”
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    The Impact of Retinal Configuration on the Protein–Chromophore Interactions in Bistable Jumping Spider Rhodopsin-1
  2. 2022
    “…High-mobility group box 1 (HMGB1) is a nuclear non-histone protein, playing a critical role as a mediator between innate and acquired immunity; when released extracellularly, it coordinates the cellular stress response (under necrosis, bacterial lipopolysaccharide stimulation) and acts as an inflammatory marker and cytokine. …”
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    High-mobility group box protein 1 expression in inflammatory diseases of the middle ear
  3. 2023
    por Pondel, Marc D, Mould, Richard
    Publicado 2005
    “…To date, little is known about the molecular mechanism(s) that activate/inhibit RAMP-1 gene expression. Such mechanism(s) are likely to play a major role in modulating the responsiveness of tissues to CGRP. …”
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    Cloning and transcriptional analysis of the mouse receptor activity modifying protein-1 gene promoter
  4. 2024
    “…Our results suggest that H3K4me1 plays an active role at enhancers by facilitating the binding of the BAF complex and possibly other chromatin regulators.…”
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    Identification of H3K4me1-Associated Proteins at Mammalian Enhancers
  5. 2025
    por Nguyen, Trang T., Venditti, Vincenzo
    Publicado 2020
    “…Enzyme I (EI), which is the key enzyme to activate the bacterial phosphotransferase system, plays an important role in the regulation of several metabolic pathways and controls the biology of bacterial cells at multiple levels. …”
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    An allosteric pocket for inhibition of bacterial Enzyme I identified by NMR-based fragment screening
  6. 2026
    “…Taking these observations into consideration, we illustrated that miR-124 could increase the radiosensitivity of CRC cells by blocking the expression of PRRX1, which indicated miR-124 could act as a great therapeutic target for CRC patients.…”
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    MiR-124 Radiosensitizes Human Colorectal Cancer Cells by Targeting PRRX1
  7. 2027
    “…In addition, Mknk1, a target gene of miR-370-3p, plays an opposing role in preadipocyte proliferation and differentiation. …”
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    miR-370-3p Regulates Adipogenesis through Targeting Mknk1
  8. 2028
    “…Caveolin-1 (Cav-1) plays pivotal roles in the endothelial damage following stroke. …”
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    Lower Serum Caveolin-1 Is Associated with Cerebral Microbleeds in Patients with Acute Ischemic Stroke
  9. 2029
    “…In addition, under heat shock stress, the Notch signal was significantly restored due to the increased expression of the Notch1 targets. These results suggest that YTHDF2 in the cytoplasm may act as an intrinsic suppressor in Notch signaling by promoting Notch1 mRNA degradation under normal cellular conditions. …”
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    YTHDF2 Suppresses Notch Signaling through Post-transcriptional Regulation on Notch1
  10. 2030
    “…Notably, W757 lies within a region of the EnvCT recently shown to act as a supporting baseplate for Env. Our data support a model in which W757 plays a key role in regulating Env biology, modulating its temporal and spatial recruitment to virus assembly sites and regulating the inherent fusogenicity of the Env ectodomain, thereby supporting efficient HIV-1 replication and spread.…”
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    A Conserved Tryptophan in the Envelope Cytoplasmic Tail Regulates HIV-1 Assembly and Spread
  11. 2031
    “…These cerium oxide nanoparticles with entrapped gadolinium deliver strong T(1) relaxivity per gadolinium ion (T(1) relaxivity, r(1) = 12.0 mM(–1) s(–1)) with the potential to act as scavengers of reactive oxygen species (ROS). …”
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    Cerium Oxide Nanoparticles with Entrapped Gadolinium for High T(1) Relaxivity and ROS-Scavenging Purposes
  12. 2032
    “…This epigenetic regulation plays an important role in the establishment and maintenance of HIV-1 latency. …”
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    Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins
  13. 2033
    por van den Elsen, Peter J.
    Publicado 2011
    “…Major histocompatibility complex (MHC)-I and MHC-II molecules play an essential role in the immune response to pathogens by virtue of their ability to present peptides to CD8(+) and CD4(+) T cells, respectively. …”
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    Expression Regulation of Major Histocompatibility Complex Class I and Class II Encoding Genes
  14. 2034
    “…Netrin-1 is a bifunctional chemotropic guidance cue that plays key roles in diverse cellular processes including axon pathfinding, cell migration, adhesion, differentiation, and survival. …”
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    The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation
  15. 2035
    “…Genome wide association studies suggest that polymorphisms within human elmo1 act as a potential contributing factor for the development of diabetic nephropathy. …”
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    ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions
  16. 2036
    “…The neural cell adhesion molecule L1 is critical for brain development and plays a role in learning and memory in the adult. …”
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    Effects of Ethanol and NAP on Cerebellar Expression of the Neural Cell Adhesion Molecule L1
  17. 2037
    “…Here we report the first analysis of the MNN1 gene family, which contains six members predicted to act as α-1,3 mannosyltransferases in the terminal stages of glycosylation. …”
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    Role of the Candida albicans MNN1 gene family in cell wall structure and virulence
  18. 2038
    “…Sphingolipids (SLs) are ubiquitous elements in eukaryotic membranes and are also found in some bacterial and viral species. As well as playing an integral structural role, SLs also act as potent signaling molecules involved in numerous cellular pathways and have been linked to many human diseases. …”
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    Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei
  19. 2039
    “…This review will focus on the pivotal role played by IFN-I in promoting tumor cell–immune cell cross talk in PDAC. …”
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    Modulation of Type I Interferon Responses to Influence Tumor-Immune Cross Talk in PDAC
  20. 2040
    “…Conclusion: Gal1 could act as a diagnostic biomarker of RA and would allow one to distinguish SpA and RA patients.…”
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    Galectin-1: A Potential Biomarker Differentiating between Early Rheumatoid Arthritis and Spondyloarthritis
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