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  1. 2041
    “…Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue (BAT). …”
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    FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis
  2. 2042
    “…Lentivirus-mediated gain and loss of function assays demonstrate that ZFP36L1 acts as a positive regulator to participate in monocyte/macrophage differentiation. …”
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    ZFP36L1 promotes monocyte/macrophage differentiation by repressing CDK6
  3. 2043
    “…Taken together, the results suggested that DlHD2 may act with DlERF1 to regulate gene expression involved in longan fruit senescence.…”
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    Histone deacetylase HD2 interacts with ERF1 and is involved in longan fruit senescence
  4. 2044
    “…BACKGROUND: Stromal fibroblasts are important determinants of tumor cell behavior. They act to condition the tumor microenvironment, influence tumor growth, support tumor angiogenesis and affect tumor metastasis. …”
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    Fibroblast EXT1-Levels Influence Tumor Cell Proliferation and Migration in Composite Spheroids
  5. 2045
    “…Finally, meiocytes missing AtPSS1 and/or SUN proteins show similar meiotic defects suggesting that AtPSS1 and SUNs act in the same pathway. …”
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    The Kinesin AtPSS1 Promotes Synapsis and is Required for Proper Crossover Distribution in Meiosis
  6. 2046
    por Möröy, Tarik, Khandanpour, Cyrus
    Publicado 2019
    “…GFI1 plays important roles in hematopoiesis, in particular by regulating both the function of hematopoietic stem- and precursor cells and differentiation along myeloid and lymphoid lineages. …”
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    Role of GFI1 in Epigenetic Regulation of MDS and AML Pathogenesis: Mechanisms and Therapeutic Implications
  7. 2047
    “…The cell cycle arrest protein FgBub2-FgBfa1 complex was shown to act as the GTPase-activating protein (GAP) for FgTem1. …”
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    The mitotic exit mediated by small GTPase Tem1 is essential for the pathogenicity of Fusarium graminearum
  8. 2048
    “…BARX1 and HSPA6 can potentially act as novel therapeutic targets for OS. …”
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    BARX1 promotes osteosarcoma cell proliferation and invasion by regulating HSPA6 expression
  9. 2049
    “…However, the pathogenesis of the pancreatic phenotype remains poorly understood. Chibby1 (Cby1), a small conserved coiled-coil protein, localizes to the ciliary base and plays a crucial role in ciliogenesis. …”
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    Loss of the ciliary protein Chibby1 in mice leads to exocrine pancreatic degeneration and pancreatitis
  10. 2050
    “…Sp1 and Ki-67 could act promising prognostic biomarkers for clinical diagnosis and treatment of cancer.…”
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    Reciprocal Role Of DNA Methylation And Sp1 Binding In Ki-67 Gene Transcription
  11. 2051
    “…To mitigate its effect in satellite communication, knowledge of local rainfall statistics is necessary which act as milestone for design of radio link. Rain attenuation is best visualize by the 1-min rainfall rate statistic but the measurement of this rain rate distribution is rare on a worldwide basis and observation of rain rate are done with longer integration times typically 30 min or more. …”
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    Rain rate modeling of 1-min from various integration times in South Korea
  12. 2052
    “…Our results show that FGFR1 gains act to attenuate the function of 4EBP1 via PI3K-mediated phosphorylation at Thr37/46, Ser65, and Thr70 sites. …”
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    Frequent 4EBP1 Amplification Induces Synthetic Dependence on FGFR Signaling in Cancer
  13. 2053
    “…These results indicate that SIRT1 is an important regulator of lipid and carbohydrate metabolisms within human fetal hepatocytes, acting as an adaptive transcriptional response to environmental changes.…”
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    SIRT1 Disruption in Human Fetal Hepatocytes Leads to Increased Accumulation of Glucose and Lipids
  14. 2054
    “…We suggest that this mixture is not only acting as an effective chemical sunscreen for pollen DNA, but may also play an important role in recognition processes during pollination.…”
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    Ligand Recognition of the Major Birch Pollen Allergen Bet v 1 is Isoform Dependent
  15. 2055
    “…BACKGROUND: Type 1 regulatory T (Tr1) cells, characterized by the secretion of high levels of the anti-inflammatory cytokine interleukin-10 (IL-10), play an important role in the regulation of autoimmune diseases and transplantation. …”
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    In Vivo Induction of Tr1 Cells via Mucosal Dendritic Cells and AHR Signaling
  16. 2056
    “…Syntenin acts as an adaptor and scaffold protein through its two PSD-95, Dlg, and ZO-1 (PDZ) domains, participating in multiple signaling pathways and modulating cellular physiology. …”
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    The Multifunctional Protein Syntenin-1: Regulator of Exosome Biogenesis, Cellular Function, and Tumor Progression
  17. 2057
    “…Our results suggest that nurr1 acts as a point of convergence for multiple signaling pathways that likely play a critical role in differentiation and phenotypic expression of dopaminergic (DAergic) neurons.…”
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    Multiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor NURR1
  18. 2058
    “…TAF1 acts as a flexible scaffold that drives the co-translational recruitment of TFIID submodules preassembled in the cytoplasm. …”
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    Hierarchical TAF1-dependent co-translational assembly of the basal transcription factor TFIID
  19. 2059
    por Martin, Pilar, Moscat, Jorge
    Publicado 2012
    “…The members of the atypical Protein Kinase Cs (aPKC) kinase subfamily, PKCζ and PKCλ/ɩ, as well as their adapters, p62 and Par-6, form part of the PB1-domain-containing group of signaling regulators. …”
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    Th1/Th2 Differentiation and B Cell Function by the Atypical PKCs and Their Regulators
  20. 2060
    “…Phosphorylation of caveolin-1 is one of the initial events leading to exacerbation of vascular permeability caused by oxidative stress. …”
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    Suppressive effects of quercetin on hydrogen peroxide-induced caveolin-1 phosphorylation in endothelial cells
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