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  1. 2061
    “…Mechanistically, Linc-ROR acts as competing endogenous RNA to stabilize DEPDC1 mRNA and regulates DEPDC1 mRNA stability by binding HNRNPK. …”
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    Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression
  2. 2062
    “…Therefore, GT1b is thought to act on another mechanism that controls intracellular Ca(2+).…”
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    Effect of ganglioside GT1b on the in vitro maturation of porcine oocytes and embryonic development
  3. 2063
    “…MACF1 plays an important role in maintaining synaptic differentiation and efficient synaptic transmission in mice, and variants in MACF1 are associated with congenital myasthenia in humans.…”
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    MACF1 links Rapsyn to microtubule- and actin-binding proteins to maintain neuromuscular synapses
  4. 2064
    “…High mobility group box 1 (HMGB1) is an abundant chromatin protein that acts as a cytokine when released in the extracellular milieu by necrotic and inflammatory cells. …”
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    Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation
  5. 2065
    “…Additional genetic experiments dissected the effects of modulating both BER and Parp1 on alkylation sensitivity in mice and determined that Aag acts upstream of Parp1 in alkylation-induced tissue damage; in fact, cytotoxicity in WT and Aag transgenic mice was abrogated in the absence of Parp1. …”
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    Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1
  6. 2066
    “…Txr1 is, therefore, likely to play a role in L-OHP resistance, acting via TSP1, and should be investigated as a potential therapeutic target in the treatment of GC.…”
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    Effects of taxol resistance gene 1 expression on the chemosensitivity of SGC-7901 cells to oxaliplatin
  7. 2067
    “…Further, MYC2 and HY1 have been shown to play important roles in jasmonic acid (JA) signaling pathways. …”
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    Functional interconnections of HY1 with MYC2 and HY5 in Arabidopsis seedling development
  8. 2068
    “…This positive regulation by MDC1 might contribute to the suppression of breast cancer progression by acting as a barrier of positive to negative ERα function transformation.…”
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    MDC1 Enhances Estrogen Receptor-mediated Transactivation and Contributes to Breast Cancer Suppression
  9. 2069
    por Seo, Soyeon, Kim, Yumi, Park, Kyyoung
    Publicado 2023
    “…Taken together, chloroplast NPR1 acts as a retrograding signal that enhances the adaptability of plants to adverse environments.…”
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    NPR1 Translocation from Chloroplast to Nucleus Activates Plant Tolerance to Salt Stress
  10. 2070
    “…We therefore hypothesized that SnRK1 may play a role in the regulation of autophagy in response to nutrient or energy deficiency in Arabidopsis. …”
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    SnRK1 activates autophagy via the TOR signaling pathway in Arabidopsis thaliana
  11. 2071
    “…In conclusion, our study clarifies that SCAMP1/miR‐499a‐5p/LMX1A/NLRC5 axis plays a critical role in modulating malignant progression of glioma cells, which provide a novel therapeutic strategy for glioma treatment.…”
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    Knockdown of LncRNA SCAMP1 suppressed malignant biological behaviours of glioma cells via modulating miR‐499a‐5p/LMX1A/NLRC5 pathway
  12. 2072
    “…BACKGROUND: With the rapid development of the high throughput detection techniques, tumor-related Omics data has become an important source for studying the mechanism of tumor progression including breast cancer, one of the major malignancies worldwide. A previous study has shown that the G2 and S phase-expressed-1 (GTSE1) can act as an oncogene in several human cancers. …”
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    GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner
  13. 2073
    “…HMGB1, which acts as a DNA chaperone to help maintain nuclear homeostasis, was reported to play a prominent role in cancer progression, angiogenesis, invasion, and metastasis development. …”
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    Suppression of Cellular Proliferation and Invasion by HMGB1 Knockdown in Bladder Urothelial Carcinoma Cells
  14. 2074
    “…TAF1 acts as a flexible scaffold that drives the co-translational recruitment of TFIID submodules preassembled in the cytoplasm. …”
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    Hierarchical TAF1-dependent co-translational assembly of the basal transcription factor TFIID
  15. 2075
    “…It is likely that DAB2IP acts as a scaffold to aid PLK1-Mps1 in targeting Cdc20. …”
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    Mitotic phosphorylation of tumor suppressor DAB2IP maintains spindle assembly checkpoint and chromosomal stability through activating PLK1-Mps1 signal pathway and stabilizing mitotic checkpoint complex
  16. 2076
    “…The M1 protein accumulates in ER during infection and this localization is indispensable for its function, suggesting M1 acts from the ER. …”
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    M1 of Murine Gamma-Herpesvirus 68 Induces Endoplasmic Reticulum Chaperone Production
  17. 2077
    “…S1P is a sphingosine-derived phospholipid that acts by binding to its receptor S1PR and is involved in the regulation of several biological processes including cell survival, differentiation, migration, proliferation, immune response, and lymphocyte trafficking. …”
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    Unveiling the biological role of sphingosine-1-phosphate receptor modulators in inflammatory bowel diseases
  18. 2078
    “…In summary, we conclude that under pro-proliferative cytokine stimulation at the onset of myeloproliferative diseases SOCS1 acts as a tumor suppressor, while under anti-proliferative conditions it exerts oncogenic function. …”
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    SOCS1 function in BCR-ABL mediated myeloproliferative disease is dependent on the cytokine environment
  19. 2079
    “…In this study, one WRKY transcription factor SmWRKY1 was isolated and functionally characterized from S. miltiorrhiza. …”
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    Transcription Factor SmWRKY1 Positively Promotes the Biosynthesis of Tanshinones in Salvia miltiorrhiza
  20. 2080
    “…BfiI, a type IIS restriction endonuclease, acts upon a specific asymmetric sequence, 5-ACTGGG-3, and precisely cuts both upper and lower DNA strands at fixed locations downstream of this sequence. …”
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    smFRET Detection of Cis and Trans DNA Interactions by the BfiI Restriction Endonuclease
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