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  1. 2081
    “…Suppressor of cytokine signaling-1 (SOCS1) acts as an important physiological regulator of cytokine responses, and silencing of the SOCS1 gene by DNA methylation has been found in several human cancers. …”
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    IFNγ-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice
  2. 2082
    “…Previous data have shown that PilY1 acts as a calcium-dependent pilus biogenesis factor necessary for twitching motility with a specific calcium binding site located at amino acids 850–859 in the 1,163 residue protein. …”
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    Pseudomonas aeruginosa PilY1 Binds Integrin in an RGD- and Calcium-Dependent Manner
  3. 2083
    “…Taken together, our data suggest that miR203 acts as a tumor suppressor in glioblastoma by suppressing the pro-tumorigenic action of STAT1. …”
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    MiRNA203 suppresses the expression of protumorigenic STAT1 in glioblastoma to inhibit tumorigenesis
  4. 2084
    “…METHODS AND RESULTS: Existing literature was used to determine the roles of CPS1 and CAD in HCC. CPS1 downregulation is thought to play a role in hepatocarcinogenesis through an increased glutamine availability for de novo pyrimidine biosynthesis, which CAD catalyzes the first three steps for. …”
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    Exploring Metabolic Consequences of CPS1 and CAD Dysregulation in Hepatocellular Carcinoma by Network Reconstruction
  5. 2085
    “…We found that the p53 signaling pathway might play a key role in the development of chemical cystitis, and Cdk1 acted as a crucial gene in the p53 signaling pathway. …”
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    Cyclin‐dependent kinase 1 shows to be a potential genetic target for chemical cystitis
  6. 2086
    “…BACKGROUND: In addition to acting as an RNA quality control pathway, nonsense-mediated mRNA decay (NMD) plays roles in regulating normal gene expression. …”
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    Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay
  7. 2087
    “…As selective forces, these adverse factors play essential roles in shaping phenotypic variation in plant populations. …”
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    Expression and Molecular Evolution of Two DREB1 Genes in Black Poplar (Populus nigra)
  8. 2088
    “…Adenosine deaminase acting on RNA 1 (ADAR1), a recently described epigenetic modifier, is believed to play a critical oncogenic role in human cancers. …”
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    ADAR1 has an oncogenic function and can be a prognostic factor in cervical cancer
  9. 2089
    “…Propagation of gene repression is sustained by cis-acting histone modifications, PRC2-mediated H3K27me3 and cPRC1-mediated H2AK119ub1, promoting a sequence-independent feedback mechanism for PcG protein recruitment. …”
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    Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing
  10. 2090
    “…Besides the well-characterized RNA editing core complex, the mitochondrial RNA-binding 1 (MRB1) complex is one of the key players. It comprises a core complex of about six proteins, guide RNA-associated proteins (GAPs) 1/2, which form a heterotetramer that binds and stabilizes gRNAs, plus MRB5390, MRB3010, and MRB11870, which play roles in initial stages of RNA editing, presumably guided by the first gRNA:mRNA duplex in the case of the latter two proteins. …”
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    Integrity of the core mitochondrial RNA-binding complex 1 is vital for trypanosome RNA editing
  11. 2091
    “…Previous studies suggest that GTP cyclohydrolase I (GCH1) may play a pivotal role in microglial activation, which has been shown to be essential for NP. …”
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    GCH1-regulated miRNAs are potential targets for microglial activation in neuropathic pain
  12. 2092
    “…DISCUSSION/SIGNIFICANCE OF FINDINGS: Overall, our results suggest that LKB1 acts through SIK1 to suppress EMT and the generation of cancer stem cells. …”
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    56371 The Signaling Axis of Tumor Suppressor LKB1 in Triple Negative Breast Cancer
  13. 2093
    “…Cis-acting element analysis showed that PheNAP1 family genes are involved in light, hormone, and abiotic stress responses and may play an important role in the rapid growth and flowering. …”
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    Genome-Wide Identification of NAP1 and Function Analysis in Moso Bamboo (Phyllostachys edulis)
  14. 2094
    “…PAI-1 has been shown to play a role in a number of diverse pathologies including cardiovascular diseases, obesity and cancer and is therefore an attractive therapeutic target. …”
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    Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1
  15. 2095
    “…It has been implicated in chromatin compaction and gene regulation and is anticipated to play a role in higher-order genome structure. Here we have used a combination of genome-wide approaches including DNA methylation, histone modification and DNase I hypersensitivity profiling as well as Hi-C to investigate the impact of reduced cellular levels of histone H1 in embryonic stem cells on chromatin folding and function. …”
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    Local compartment changes and regulatory landscape alterations in histone H1-depleted cells
  16. 2096
    “…PURPOSE: Sigma receptor 1 (σR1) is a non-opioid transmembrane protein that may act as a molecular chaperone at the endoplasmic reticulum–mitochondrial membrane. …”
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    Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1
  17. 2097
    “…BACKGROUND: Loss of the Sortilin-related receptor 1 (SORL1) gene seems to act as a causal event for Alzheimer’s disease (AD). …”
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    The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons
  18. 2098
    “…Subsequent to translocation, nuclear IκB proteins play an important role in the regulation of NF-κB transcriptional activity by acting either as activators or inhibitors. …”
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    Structure-Function Relationship of Cytoplasmic and Nuclear IκB Proteins: An In Silico Analysis
  19. 2099
    “…Addition of VB6 in the conidial suspentions could rescue the defects of appressorium turgor pressure at 14 hpi or 24 hpi, invasive growth and pathogenicity of the MoPDX1 deletion mutants. Indicated that MoPdx1 affected the appressorium turgor pressure, invasive growth and virulence mainly depended on de novo VB6, and VB6 was biosynthesized in conidia, then transported into the appressorium, which play important roles in substances transportation from conidia to appressorium thus to regulate the appressorium turgor pressure. …”
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    Pyridoxine biosynthesis protein MoPdx1 affects the development and pathogenicity of Magnaporthe oryzae
  20. 2100
    por Mishra, Seema
    Publicado 2014
    “…Further, CTNNB1, CSNK1A1, and Gli2 proteins may act as key drug targets common to these pathways. …”
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    CSNK1A1 and Gli2 as Novel Targets Identified Through an Integrative Analysis of Gene Expression Data, Protein-Protein Interaction and Pathways Networks in Glioblastoma Tumors: Can These Two Be Antagonistic Proteins?
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