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  1. 2101
    “…Taken together, our findings indicate that AGAP2-AS1 may act as an oncogene by repressing tumor-suppressor LATS2 and KLF2 transcription. …”
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    Upregulated long non-coding RNA AGAP2-AS1 represses LATS2 and KLF2 expression through interacting with EZH2 and LSD1 in non-small-cell lung cancer cells
  2. 2102
    “…BACKGROUND: In a previous study, we confirmed that netrin-1 acts as an antiangiogenic factor by inhibiting alkali burn-induced corneal neovascularization in rats. …”
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    Effects of intravitreal injection of netrin-1 in retinal neovascularization of streptozotocin-induced diabetic rats
  3. 2103
    “…Ethanol promoted the upregulation of Cxcl1 and Cxcl6 mRNA and proteins in models of early ALD, denoting their potentiality of acting as biomarkers of ALD.…”
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    Ethanol promoting the upregulation of C-X-C Motif Chemokine Ligand 1（CXCL1） and C-X-C Motif Chemokine Ligand 6（CXCL6） in models of early alcoholic liver disease
  4. 2104
    por Lee, Sang-Hoon, Park, Seok-Rae
    Publicado 2018
    “…Taken together, these results suggest that TLR1/2 agonist Pam3CSK4 acts as a potent mouse B cell mitogen in combination with TLR4 agonist LPS, but these 2 different TLR agonists play diverse roles in regulating the Ig CSR of each isotype, particularly IgG1/IgE and IgG2a.…”
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    Toll-like Receptor 1/2 Agonist Pam3CSK4 Suppresses Lipopolysaccharide-driven IgG1 Production while Enhancing IgG2a Production by B Cells
  5. 2105
    “…Molecular dynamics simulations are performed to investigate the dynamic properties of wild-type HIV-1 protease and its two multi-drug-resistant variants (Flap + (L10I/G48V/I54V/V82A) and Act (V82T/I84V)) as well as their binding with APV and DRV inhibitors. …”
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    Effects of drug-resistant mutations on the dynamic properties of HIV-1 protease and inhibition by Amprenavir and Darunavir
  6. 2106
    Publicado 1985
    “…These results suggest that LFA-1 may act by binding to ligands that are not present on all cells. …”
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    Major histocompatibility complex-restricted antigen receptor on T cells. VIII. Role of the LFA-1 molecule
  7. 2107
    por Prise, Ian, Sharrocks, Andrew D.
    Publicado 2019
    “…One of its key nuclear targets is the transcription factor ELK1, which has been shown to play an important role in controlling gene expression in human embryonic stem cells (hESCs). …”
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    ELK1 has a dual activating and repressive role in human embryonic stem cells
  8. 2108
    “…Four proteins were identified, including apoA4, alpha1-ACT, HABP2, and keratin 10, with blood levels changed significantly between CC and AA homozygotes of rs12742393. …”
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    Serum Proteome Changes in Healthy Subjects with Different Genotypes of NOS1AP in the Chinese Population
  9. 2109
    por Brown, Susie L., Kendrick, Samantha
    Publicado 2021
    “…Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-motif. When within promoter regions, the i-motif has the potential to act as a molecular switch for controlling gene expression. …”
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    The i-Motif as a Molecular Target: More Than a Complementary DNA Secondary Structure
  10. 2110
    “…Taken together, Cav-1 seems playing a different role in different cancer subtypes even of the same organ, as well as acting differently in the same cancer subtype of different organs. …”
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    The different functions and clinical significances of caveolin-1 in human adenocarcinoma and squamous cell carcinoma
  11. 2111
    “…Metastasis-associated in colon cancer-1 (MACC1) is an oncogene that is overexpressed in gastric cancer (GC) and plays an important role in GC progression, though it is unclear how MACC1 activity is regulated in GC. …”
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    MACC1 mediates acetylcholine-induced invasion and migration by human gastric cancer cells
  12. 2112
    “…Previous studies have demonstrated that CD1d-restricted type I NKT cells usually act as pro-inflammatory cells but sometimes behave as anti-inflammatory cells. …”
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    CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides
  13. 2113
    “…The parathyroid hormone type 1 receptor (PTH1R), a class B1 G protein-coupled receptor, plays critical roles in bone turnover and Ca(2+) homeostasis. …”
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    Molecular insights into the distinct signaling duration for the peptide-induced PTH1R activation
  14. 2114
    “…Our study not only demonstrated a role for MLL1 in the proliferation and metastasis of cervical carcinoma cells but also revealed the interaction of MLL1 with β-catenin to play a different role.…”
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    MLL1 promotes cervical carcinoma cell tumorigenesis and metastasis through interaction with β-catenin
  15. 2115
    “…Hox genes, a highly conserved homolog in most animals, play vital functions in cell development and organ formation. …”
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    Identification of HOXA1 as a Novel Biomarker in Prognosis of Head and Neck Squamous Cell Carcinoma
  16. 2116
    “…Cognitive impairment patients often have a delayed diagnosis because there are no early symptoms or conventional diagnostic methods. Exosomes play a vital role in cell-to-cell communications and can act as promising biomarkers in diagnosing diseases. …”
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    Proteomics of serum exosomes identified fibulin-1 as a novel biomarker for mild cognitive impairment
  17. 2117
    “…In both malignancies, FoxA1 plays a pivotal role from early stage cancer through to drug resistant and metastatic disease. …”
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    FoxA1 is a Key Mediator of Hormonal Response in Breast and Prostate Cancer
  18. 2118
    “…Furthermore, we find that DEX-1 is required for proper dauer mobility. We show that DEX-1 is secreted from the seam cells during dauer, but acts locally in a cell-autonomous manner. …”
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    Epidermal Remodeling in Caenorhabditis elegans Dauers Requires the Nidogen Domain Protein DEX-1
  19. 2119
    “…Accumulation of catecholamines plays an important role in the pathogenesis of heart disease. …”
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    β-Adrenergic Receptor-Stimulated Cardiac Myocyte Apoptosis: Role of β1 Integrins
  20. 2120
    “…The SCP1 plays a vital role in various biological activities, like neuronal gene silencing and preferential Ser5 dephosphorylation, acts as a cardiac hypertrophy inducer with the help of its intronic miRNAs, and has shown a key role in cell cycle regulation. …”
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    The diverse roles of RNA polymerase II C-terminal domain phosphatase SCP1
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