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  1. 2121
    “…Defensins are cationic peptides that are produced by the mucosal epithelia and have broad-spectrum antimicrobial activity. Sheep β-defensin-1 (SBD-1) is one of the most important antibacterial peptides in the rumen. …”
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    Modulation of ovine SBD-1 expression by Saccharomyces cerevisiae in ovine ruminal epithelial cells
  2. 2122
    “…Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer extracellular milieu. …”
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    Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks
  3. 2123
    “…BACKGROUND: Disheveled-associated activator of morphogenesis 1 (DAAM1) is a formin acting downstream of Wnt signaling that is important for planar cell polarity. …”
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    DAAM1 Is a Formin Required for Centrosome Re-Orientation during Cell Migration
  4. 2124
    “…The manner in which RDM1 acts in both the DDR complex and as a factor bridging DRM2 and AGO4 remains unclear. …”
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    The Ability to Form Homodimers Is Essential for RDM1 to Function in RNA-Directed DNA Methylation
  5. 2125
    “…CD26, acting as a costimulator of T cell activation, plays an important role in the immune system. …”
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    Involvement of CD26 in Differentiation and Functions of Th1 and Th17 Subpopulations of T Lymphocytes
  6. 2126
    “…Multiple studies have found that IGF/IGF-1R pathway plays an important role in the occurrence and development of pain. …”
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    IGF/IGF-1R signal pathway in pain: a promising therapeutic target
  7. 2127
    “…Our findings revealed that UCHL1 acts as a tumor suppressor gene in NPC and thus provided a novel therapeutic target for NPC treatment.…”
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    Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN)
  8. 2128
    “…In the present study, we revealed that the Hippo transducer, the transcriptional coactivator with PDZ-binding motif (TAZ), acts as a downstream mediator of PODXL in colon cancer. …”
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    Podocalyxin-Like Protein 1 Regulates TAZ Signaling and Stemness Properties in Colon Cancer
  9. 2129
    por Pathak, Himani, Varghese, Jishy
    Publicado 2021
    “…Here, we report that Edem1 (endoplasmic reticulum degradation–enhancing α-mannosidase–like protein 1), an endoplasmic reticulum–resident protein involved in protein quality control, acts in the fat body to regulate insulin signalling and thereby the metabolic status in Drosophila. …”
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    Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in Drosophila
  10. 2130
    “…Peroxiredoxin I (Prx I) plays an important role in cancer development and inflammation. …”
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    Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I
  11. 2131
    “…The protein stromal interaction molecule 1 (STIM1) plays a pivotal role in mediating store-operated calcium entry (SOCE) into cells, which is essential for adaptive immunity. …”
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    Resonance assignment of coiled-coil 3 (CC3) domain of human STIM1
  12. 2132
    “…BACKGROUND: High mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) molecule that plays a central role in innate immunity. …”
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    USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity
  13. 2133
    “…CONCLUSIONS: Our findings demonstrate that LKB1 in hypothalamic POMC neurons plays a key role in the central regulation of peripheral glucose metabolism but not body-weight control. …”
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    Deletion of Lkb1 in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice
  14. 2134
    “…Sulf1 acts extracellularly to modify the structure of heparan sulfate chains to affect the bio-availability of Wnt ligands. …”
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    Sulf1 has ligand-dependent effects on canonical and non-canonical Wnt signalling
  15. 2135
    “…Here, we unraveled that Arabidopsis NAC domain-containing protein 17 (ANAC017) acts downstream of RCD1 in salt stress response, and its ER-to-nucleus transport is triggered by high salinity. …”
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    RCD1 Promotes Salt Stress Tolerance in Arabidopsis by Repressing ANAC017 Activity
  16. 2136
    “…Thus, hMCPH1 acts as a composite modulator of condensin II to regulate chromosome condensation and shaping.…”
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    MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II
  17. 2137
    “…OsSTAP1 is localized to the nucleus and acts as a transcriptional activator in plant cells. …”
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    Overexpression of the Transcription Factor Gene OsSTAP1 Increases Salt Tolerance in Rice
  18. 2138
    “…OBJECTIVE: Insulin-like growth factor 1 receptor (IGF1R) acts at the crossroad between immunity and cancer, being an attractive therapeutic target in these areas. …”
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    IGF1R signalling is a guardian of self-tolerance restricting autoantibody production
  19. 2139
    “…Consistent with a block in axonal transport, we find a decrease in number of active zones and reduced neurotransmission in flies overexpressing Par-1 kinase. Interestingly, we find that Par-1 acts independently of Tau-one of the most well studied substrates of Par-1, revealing a presynaptic function for Par-1 that is independent of Tau. …”
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    Active zone proteins are transported via distinct mechanisms regulated by Par-1 kinase
  20. 2140
    “…We identified that TIP60-mediated growth suppression of HPV-induced cervical cancer is mediated in part due to TERT repression through Sp1 acetylation. In summary, our study has identified a novel substrate for TIP60 catalytic activity and a unique repressive mechanism acting at the TERT promoter in virus-induced malignancies.…”
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    TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter
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