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  1. 2161
    “…CONCLUSION: Our results demonstrated that CD68 acted as an immune suppressor and contributed to glioma progression in the tumor microenvironment. …”
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    Specific clinical and immune features of CD68 in glioma via 1,024 samples
  2. 2162
    “…Acting as the building block of the HIV-1 capsid core, the HIV-1 capsid protein plays an important role in the viral life cycle and is an attractive target for antiviral development. …”
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    Structure-based virtual screening workflow to identify antivirals targeting HIV-1 capsid
  3. 2163
    “…Additionally, we experimentally demonstrated that neutralizing JAG1 inhibited cancer cell plasticity. Conclusions: Our results indicate that JAG1 on PDAC plays a critical role in cancer cell plasticity and maintenance of tumor heterogeneity.…”
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    The role of Jagged1 as a dynamic switch of cancer cell plasticity in PDAC assembloids
  4. 2164
    “…The Us3 kinase plays a crucial role in nucleus to cytoplasm capsid translocation. …”
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    Nuclear envelope impairment is facilitated by the herpes simplex virus 1 Us3 kinase
  5. 2165
    “…INTRODUCTION: High mobility group box chromosomal protein 1 (HMGB1) is a nuclear protein that acts as a pro-inflammatory mediator following extracellular release. …”
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    Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis
  6. 2166
    “…CONCLUSIONS: MiR-485-5p acts as a tumor suppressor by targeting NUDT1 in GC. …”
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    The role of miR-485-5p/NUDT1 axis in gastric cancer
  7. 2167
    “…Thus, we hypothesize that ABCA1 plays a pro-immune function and could be a potential therapeutic target to boost the immune system. …”
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    OR30-4 Role of ABCA1 in Myeloid Cell Function and Breast Cancer Progression
  8. 2168
    “…The miR-204 acts as a tumour suppressor by inhibiting NUAK1 expression in NSCLC. …”
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    MiR-204 inhibits human NSCLC metastasis through suppression of NUAK1
  9. 2169
    “…Furthermore, we demonstrated that PRY-1 acts upstream of the WNT asymmetry pathway components WRM-1, LIT-1, and POP-1, and miRNA target genes in seam cell development. …”
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    Role of PRY-1/Axin in heterochronic miRNA-mediated seam cell development
  10. 2170
    por Nip, Angel Siu Ying
    Publicado 2020
    “…Research suggests that inflammation plays a role in the onset and maintenance of eating-related maladaptive behaviors. …”
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    MON-665 Hypothalamic Gliosis in Adolescents with Type 1 Diabetes and Disordered Eating Behaviors
  11. 2171
    “…EID3 knocking down also greatly inhibited tumor growth in SCID mice. Knocking down of AMPKα1 could effectively rescue glioma cells from apoptosis and cell death caused by EID3 absence, indicating that AMPKα1 acted as a key downstream regulator of EID3 and mediated suppression effects caused by EID3 knocking down inhibition. …”
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    EID3 Promotes Glioma Cell Proliferation and Survival by Inactivating AMPKα1
  12. 2172
    “…IL-1β release is promoted by ATP acting at the purinergic P2X(7) receptor (P2X(7)R) in cells primed with toll-like receptor (TLR) ligands. …”
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    Serum amyloid A primes microglia for ATP-dependent interleukin-1β release
  13. 2173
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    Validation of an iPad activity to measure preschool children’s food and physical activity knowledge and preferences
  14. 2174
    “…We propose that hnRNP A1 and KSRP play antagonistic roles in the posttranscriptional regulation of let-7a expression.…”
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    Antagonistic role of hnRNP A1 and KSRP in the regulation of Let-7a biogenesis
  15. 2175
    “…NAP-1 fold histone chaperones play an important role in escorting histones to and from sites of nucleosome assembly and disassembly. …”
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    The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution
  16. 2176
    “…RNF213 gene mutations have been associated with MMD, so we investigated whether rare variants of RNF213 could act as genetic modifiers of MMS phenotype in a pediatric cohort of 20 MMS children, 25 children affected by isolated MMD and 47 affected only by isolated NF1. …”
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    Moyamoya Vasculopathy in Neurofibromatosis Type 1 Pediatric Patients: The Role of Rare Variants of RNF213
  17. 2177
    “…In this issue of Genes & Development, Shyian and colleagues (pp. 87–98) show that in budding yeast, the fork protection complex Tof1–Csm3 interacts physically with DNA topoisomerase I (Top1) at replication forks through the C-terminal domain of Tof1. …”
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    Top1 and Top2 promote replication fork arrest at a programmed pause site
  18. 2178
    “…Binding of programmed cell death ligand 1 (PD-L1) to its receptor programmed cell death protein 1 (PD-1) can lead to the inactivation of cytotoxic T lymphocytes, which is one of the mechanisms for immune escape of tumors. …”
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    The Importance of Exosomal PD-L1 in Cancer Progression and Its Potential as a Therapeutic Target
  19. 2179
    “…BACKGROUND: Lipopolysaccharide (LPS)/Endotoxin is hypothesized to play an important role in chronic inflammation associated with Type-1 diabetes (T1DM) and its complications. …”
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    Chronic Endotoxemia in Subjects with Type-1 Diabetes Is Seen Much before the Onset of Microvascular Complications
  20. 2180
    “…We recently showed that canonical protein disulfide isomerase (PDI) and a conotoxin-specific PDI (csPDI) are ubiquitously expressed in the venom gland of cone snails and play a major role in conotoxin folding. Here, we identify cone snail endoplasmic reticulum oxidoreductin-1 (Conus Ero1) and investigate its role in the oxidative folding of conotoxins through reoxidation of cone snail PDI and csPDI. …”
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    Ero1-Mediated Reoxidation of Protein Disulfide Isomerase Accelerates the Folding of Cone Snail Toxins
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