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  1. 2221
    “…In addition, ectopic expression of long noncoding RNAs (lncRNAs) is reported to play a pivotal role in multiple human cancers. Based on these findings, we examined lncRNA ABHD11 antisense RNA 1 (ABHD11-AS1) expression and its clinical significance, biological function and mechanism in PTC. …”
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    Long noncoding RNA ABHD11-AS1 functions as a competing endogenous RNA to regulate papillary thyroid cancer progression by miR-199a-5p/SLC1A5 axis
  2. 2222
    “…The viral membrane protein US9p and the membrane glycoprotein heterodimer gE/gI play critical roles in anterograde spread of both HSV-1 and PRV, and several models exist to explain their function. …”
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    Deletion of the Pseudorabies Virus gE/gI-US9p complex disrupts kinesin KIF1A and KIF5C recruitment during egress, and alters the properties of microtubule-dependent transport in vitro
  3. 2223
    “…RESULTS: Tropomyosin Tm5NM-1 was identified as one of the TTC9A partner proteins. …”
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    Tetratricopeptide repeat domain 9A is an interacting protein for tropomyosin Tm5NM-1
  4. 2224
    “…Since histones act as damage molecules, abzymes against histones and MBP can play a negative role in the pathogenesis of MS and probably other different diseases as well.…”
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    Multiple Sclerosis: Enzymatic Cross Site-Specific Hydrolysis of H1 Histone by IgGs against H1, H2A, H2B, H3, H4 Histones, and Myelin Basic Protein
  5. 2225
    “…Oxa1 and Mba1 overlap in function and substrate specificity, but both can act independently of each other. …”
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    Mba1, a Novel Component of the Mitochondrial Protein Export Machinery of the Yeast Saccharomyces cerevisiae
  6. 2226
    “…Our study showed that MLL1 plays a key role in promoting progesterone signalling transmission.…”
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    Mixed‐lineage leukaemia 1 contributes to endometrial stromal cells progesterone responsiveness during decidualization
  7. 2227
    “…We show that DOP-1 plays a negative role in sustaining swimming behavior. …”
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    Dopamine receptor DOP-1 engages a sleep pathway to modulate swimming in C. elegans
  8. 2228
    “…The C. albicans-specific gene EED1 plays a crucial role in this extension and maintenance of filamentous growth. eed1Δ cells failed to extend germ tubes into long filaments and switched back to yeast growth after 3 h of incubation during growth on plastic surfaces. …”
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    The Candida albicans-Specific Gene EED1 Encodes a Key Regulator of Hyphal Extension
  9. 2229
    “…We demonstrate that type 1 pili, encoded in the E. coli core genome, play an essential role in ETEC virulence, acting in concert with plasmid-encoded pathovar specific colonization factor (CF) fimbriae to promote optimal bacterial adhesion to cultured intestinal epithelium (CIE) and to epithelial monolayers differentiated from human small intestinal stem cells. …”
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    Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions
  10. 2230
    “…Taken together with other results, our data show that the MTA proteins act as scaffolds for NuRD complex assembly. We further show that the RbAp48-MTA1 interaction is essential for the in vivo integration of RbAp46/48 into the NuRD complex.…”
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    Insight into the Architecture of the NuRD Complex: STRUCTURE OF THE RbAp48-MTA1 SUBCOMPLEX
  11. 2231
    “…With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a central role in many functions of the biology of eukaryotic cells, including Plasmodium falciparum. …”
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    Characterization of a Protein Phosphatase Type-1 and a Kinase Anchoring Protein in Plasmodium falciparum
  12. 2232
    “…Complex interactions exist between cytokines, and the interleukin family plays a fundamental role in inflammation. Particularly circulating IL-1β, IL-6 and IL-8 are unregulated in systemic and chronic inflammatory conditions. …”
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    Effects of IL-1β, IL-6 and IL-8 on erythrocytes, platelets and clot viscoelasticity
  13. 2233
    “…OBJECTIVE: To determine the expression of two antimicrobial peptide genes, defensin A and cecropin A, in Aedes aegypti mosquitoes infected with DENV-1. MATERIALS AND METHODS: We used the F(1) generation of mosquitoes orally infected with DENV-1 and real-time PCR analysis to determine whether the defensin A and cecropin A genes played a role in controlling DENV-1 replication in Ae. aegypti. …”
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    Inhibition of defensin A and cecropin A responses to dengue virus 1 infection in Aedes aegypti
  14. 2234
    “…In this study, we identify the sulfotransferase family 2A member 1 (SULT2A1) to 27‐hydroxycholesterol (27‐OHC) metabolic axis as playing a critical role in HCC metastasis. …”
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    27‐Hydroxycholesterol promotes metastasis by SULT2A1‐dependent alteration in hepatocellular carcinoma
  15. 2235
    “…Given previous findings from cell lines, FoxA1 appears to play a critical role in this reprogramming of ER binding.…”
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    To bind or not to bind - FoxA1 determines estrogen receptor action in breast cancer progression
  16. 2236
    “…Our findings propose that Ago-1 acts as a key regulator in controlling cell death, tumor regression and stress response in metazoan providing a constructive bridge between RNAi machinery and cell death.…”
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    Two way controls of apoptotic regulators consign DmArgonaute-1 a better clasp on it
  17. 2237
    “…Conclusions: IDO1/COX2 coexpression plays a pivotal role and may act as a potential prognostic biomarker for survival in CRC patients with liver oligometastases.…”
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    IDO1/COX2 Expression Is Associated with Poor Prognosis in Colorectal Cancer Liver Oligometastases
  18. 2238
    por Zhang, Ting, Xu, Yue, Liu, Yanfen, Ye, Yihong
    Publicado 2015
    “…Instead, gp78 appears to act downstream of Hrd1 to promote ERAD via cooperation with the BAG6 chaperone complex. …”
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    gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum
  19. 2239
    por Mey, Jacob T., Haus, Jacob M.
    Publicado 2018
    “…Glyoxalase-1 (GLO1) is a ubiquitously expressed cytosolic protein which plays a role in the natural maintenance of cellular health and is abundantly expressed in human skeletal muscle. …”
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    Dicarbonyl Stress and Glyoxalase-1 in Skeletal Muscle: Implications for Insulin Resistance and Type 2 Diabetes
  20. 2240
    “…PTPN6 mediated the regulation between HNRNPH1 and PI3K/AKT activation. Furthermore, the HNRNPH1–PTPN6–PI3K/AKT axis played a critical role in CML tumorigenesis and development. …”
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    HNRNPH1 Is a Novel Regulator Of Cellular Proliferation and Disease Progression in Chronic Myeloid Leukemia
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