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  1. 2261
    por Dai, Gucan
    Publicado 2022
    “…β-Secretase 1 (β-site amyloid precursor protein [APP]-cleaving enzyme 1, BACE1) plays a crucial role in the amyloidogenesis of Alzheimer’s disease (AD). …”
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    Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1
  2. 2262
    “…Furthermore, we find that sek-1 acts in mature neurons to modulate locomotion. …”
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    The SEK-1 p38 MAP Kinase Pathway Modulates Gq Signaling in Caenorhabditis elegans
  3. 2263
    “…We show here that during wound-induced cell migration, the small G protein Cdc42 acts through the polarity protein Dlg1 to regulate the interaction of dynein with microtubules of the cell front. …”
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    Dlg1 binds GKAP to control dynein association with microtubules, centrosome positioning, and cell polarity
  4. 2264
    “…Increasing evidence has shown that vitamin D has immunoregulation and anti-inflammatory effects, and it may play a role in T cell regulatory responses due to downregulation in the expression of cathepsin G and inhibition of CD4+ T cell activation and protection of β cells from immune attack and is beneficial in decreasing oxidative stress in T1DM patients. …”
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    Progress in the Relationship between Vitamin D Deficiency and the Incidence of Type 1 Diabetes Mellitus in Children
  5. 2265
    “…Through bioinformatic analyses and dual-luciferase reporter assays, we showed that circXPO1 directly bound to miR-7-5p, which acted as a tumor suppressor through the negative regulation of RAF1. …”
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    CircXPO1 Promotes Glioblastoma Malignancy by Sponging miR-7-5p
  6. 2266
    “…Phosphatidylinositol (PI) turnover is thought to play an important role in the regulation of cell growth. …”
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    Overexpression of Phosphatidylinositol Synthase Enhances Growth and G1 Progression in NIH3T3 cells
  7. 2267
    por Harant, Hanna
    Publicado 2022
    “…A combination of TAT-I24 with the nucleoside analogue cidofovir showed enhancement of the antiviral effect, demonstrating that viral replication can be more efficiently inhibited with a combination of drugs acting at different stages of the viral life-cycle.…”
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    Selective Inhibition of Murine Cytomegalovirus Viral Gene Expression by the Antiviral Peptide TAT-I24
  8. 2268
    “…Oxidative stress enhances COPD inflammation under the control of the pro-inflammatory redox-sensitive transcription factor nuclear factor-kappaB (NF-κB). Histone acetylation plays a critical role in chronic inflammation and bromodomain and extra terminal (BET) proteins act as “readers” of acetylated histones. …”
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    Brd4 Is Essential for IL-1β-Induced Inflammation in Human Airway Epithelial Cells
  9. 2269
    “…We show that Sgs1 acts upon ssDNA bound by either replication protein A (RPA) or the recombinase Rad51. …”
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    The RecQ helicase Sgs1 drives ATP-dependent disruption of Rad51 filaments
  10. 2270
    “…The polo-box domain (PBD) present in Plk1’s C-terminal non-catalytic region has been shown to play a central role in targeting the N-terminal kinase domain of Plk1 to specific subcellular locations. …”
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    Mechanisms Underlying Plk1 Polo-Box Domain-Mediated Biological Processes and Their Physiological Significance
  11. 2271
    “…We discuss how inactivation of IFNAR1 in CAFs acts to stimulate stromagenesis and tumor growth.…”
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    Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intra-tumoral stromagenesis
  12. 2272
    “…The modest contributions to energy balance attributable to leptin action via many previously-studied LepR-b populations(5–9) suggest that other, heretofore unidentified, hypothalamic LepR-b neurons play important roles. Here, we examine the role of LepR-b in neuronal nitric oxide synthase (NOS1)-expressing (LepR-b(NOS1)) neurons that comprise approximately 20% of hypothalamic LepR-b neurons. …”
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    Leptin action via hypothalamic nitric oxide synthase-1 neurons controls energy balance
  13. 2273
    “…Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide, and about 30% of the pneumococcal clinical isolates show type I pili-like structures. These long proteinaceous polymers extending from the bacterial surface are encoded by pilus islet 1 and play major roles in adhesion and host colonization. …”
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    A Small Non-Coding RNA Modulates Expression of Pilus-1 Type in Streptococcus pneumoniae
  14. 2274
    “…CUB-domain containing protein 1 (CDCP1) is a transmembrane protein acting as an effector of SRC family kinases, which play an oncogenic role in multiple human cancers. …”
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    Overexpression of CDCP1 is Associated with Poor Prognosis and Enhanced Immune Checkpoints Expressions in Breast Cancer
  15. 2275
    “…Nevertheless, their use is severely hampered by the risk of developing side effects and the occurrence of Dex resistance. LncRNA NEAT1 plays a oncogenic role and participates in drug resistance in many solid tumors. …”
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    Expression of NEAT1 can be used as a predictor for Dex resistance in multiple myeloma patients
  16. 2276
    “…Here, we found that KLF4 played as a tumor-promoting gene in NPC, and could be mediated by PLK1. …”
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    Polo-Like Kinase 1 phosphorylates and stabilizes KLF4 to promote tumorigenesis in nasopharyngeal carcinoma
  17. 2277
    “…Recent discoveries have suggested that the F-actin capping protein α1 subunit (CAPZA1) in various human tumors could play a significantly important role in regulating cell proliferation, metastasis, and epithelial–mesenchymal transition. …”
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    NcRNA-regulated CAPZA1 associated with prognostic and immunological effects across lung adenocarcinoma
  18. 2278
    “…Here, we show that NA modulates hyperpolarization-activated currents (I(h)) via the activation of α(2)-adrenergic receptors (ARs) in adult-born GCs (abGCs), thus directly acting on channels that play essential roles in regulating neuronal excitability and network oscillations in the brain. …”
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    α(2)-Adrenergic modulation of I(h) in adult-born granule cells in the olfactory bulb
  19. 2279
    “…Minutes before egress, an essential parasite serine protease called SUB1 is discharged into the parasitophorous vacuole, where it proteolytically processes a subset of parasite proteins that play indispensable roles in egress and invasion. …”
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    The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin
  20. 2280
    “…BACKGROUND: The adenosine deaminase acting on RNA 1 (ADAR1) specifically deaminates adenosine to inosine in double-stranded RNA (dsRNA). …”
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    ADAR1 silencing-induced HUVEC apoptosis is mediated by FGFR2 under hypoxia stress
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