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  1. 9501
    “…WNK2 was identified as a target gene of CBX8, which interacted with the WNK2 promoter to suppress WNK2 expression and activity. WNK2 acted as an antioncogene, and decreased WNK2 levels resulted in high activity of matrix metalloprotease (MMP)-2 and RAC1, which play a central role in invasion and migration, respectively. …”
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    Upregulated CBX8 Promotes Cancer Metastasis via the WNK2/MMP2 Pathway
  2. 9502
    “…Pathway analysis shows that HNF4G may act in PDAC through the cell-cell junction pathway. …”
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    Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation
  3. 9503
    “…We show that DOC2B may act as a metastatic suppressor by inhibiting EMT through induction of senescence via DOC2B-calcium-EMT-senescence axis. …”
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    Metastatic suppression by DOC2B is mediated by inhibition of epithelial-mesenchymal transition and induction of senescence
  4. 9504
    “…A relative fitness value of 1.0, marked by the dotted line, denotes equal fitness with WT. …”
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    258. Clinical Rel Mutations in Staphylococcus aureus Primes Pathogen Expansion Under Nutrient Stress
  5. 9505
    “…Retinal Müller glia (MG) can act as stem-like cells to generate new neurons in both zebrafish and mice. …”
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    Transcriptomic comparison of two selective retinal cell ablation paradigms in zebrafish reveals shared and cell-specific regenerative responses
  6. 9506
    “…We thus used the developing wing to investigate the role played in tissue homeostasis by the evolutionarily conserved eukaryotic H/ACA small nucleolar ribonucleoprotein pseudouridine synthase. …”
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    Loss of Drosophila pseudouridine synthase triggers apoptosis-induced proliferation and promotes cell-nonautonomous EMT
  7. 9507
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    Exposing an “Intangible” Cognitive Skill Among Collegiate Football Players: III. Enhanced Reaction Control to Motion
  8. 9508
    “…Intriguingly, these metabolites have little effects on the activation of interferon regulatory factors (IRFs) for the production of type I interferons (IFNs) for antiviral defenses. These data suggest that circulating metabolites resulting from COVID-19 infection may act as effectors to elicit the peculiar systemic inflammatory responses, exhibiting severely strong proinflammatory cytokine production with limited induction of the interferons. …”
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    Identification of serum metabolites enhancing inflammatory responses in COVID-19
  9. 9509
    “…The chronic use of opiates (i.e., narcotics such as the natural derivatives of opium including morphine or codeine) or opioids (i.e., semisynthetic derivatives of opium and other molecules that activate opioid receptors) induces dependence, which is associated with various specific behavioral and somatic signs after their withdrawal or after the administration of an opioid antagonist. …”
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    An Emerging New Paradigm in Opioid Withdrawal: A Critical Role for Glia-Neuron Signaling in the Periaqueductal Gray
  10. 9510
    “…Importantly, Y740 on the DDR2 catalytic loop was found in this cluster indicating that insulin acts to promote collagen I signaling by increasing the activity of DDR2. …”
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    Phosphoproteomic analysis identifies insulin enhancement of discoidin domain receptor 2 phosphorylation
  11. 9511
    “…Siglec-1, Siglec-5, and Siglec-14 play bidirectional roles through modulation of inflammation and immunity. …”
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    Sialic Acids in the Immune Response during Sepsis
  12. 9512
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    Functional microRNA targetome undergoes degeneration-induced shift in the retina
  13. 9513
    “…Previously, we have demonstrated that the IRES trans-acting factor (ITAF), hnRNP A1 is required to promote IRES activity and small molecule inhibitors which bind specifically to this ITAF and curtail IRES activity, leading to mTOR inhibitor sensitivity. …”
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    Repurposing Potential of Riluzole as an ITAF Inhibitor in mTOR Therapy Resistant Glioblastoma
  14. 9514
    “…Smad7 has been identified as a negative regulator of the transforming growth factor TGF-β pathway by direct interaction with the TGF-β type I receptor (TβR-I). Although Smad7 has also been shown to play TGF-β unrelated functions in the cytoplasm and in the nucleus, a comprehensive analysis of its nuclear function has not yet been performed. …”
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    Genome-Wide Analysis of Smad7-Mediated Transcription in Mouse Embryonic Stem Cells
  15. 9515
    “…In this study, genes encoding NRT with Major Facilitator Superfamily (MFS) domain were identified in trifoliate orange (Poncirus trifoliata (L.) Raf.). Totally, 56 NRT1s, 6 NRT2s, and 2 NAR2s were explored. The bioinformation analysis, including protein characteristics, conserved domain, motif, phylogenetic relationship, cis-acting element, and synteny correlation, indicated the evolutionary conservation and functional diversity of NRT genes. …”
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    Genome-Wide Identification of NRT Gene Family and Expression Analysis of Nitrate Transporters in Response to Salt Stress in Poncirus trifoliata
  16. 9516
    “…It leads to the activation of and subsequent release of proinflammatory cytokines such as IL-1β and IL-18. S. Typhimurium is a Gram-negative intracellular bacterium, which is known to trigger inflammasome assembly via recognition by the cytosolic receptors, NLRP3 and NLRC4 (which act via the adaptor protein, ASC) to induce cell death and cytokine release. …”
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    Limited role for ASC and NLRP3 during in vivo Salmonella Typhimurium infection
  17. 9517
    “…The three-dimensional organization of a genome plays a critical role in regulating gene expression, yet little is known about the machinery and mechanisms that determine higher-order chromosome structure(1,2). …”
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    Condensin-Driven Remodeling of X-Chromosome Topology during Dosage Compensation
  18. 9518
    “…Transient changes in intracellular Ca(2+) concentration have been well recognized to act as cell signals coupling various environmental stimuli to appropriate physiological responses with accuracy and specificity in plants. …”
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    Involvement of calmodulin and calmodulin-like proteins in plant responses to abiotic stresses
  19. 9519
    “…In this article we propose that infants' agentivity develops out of participation, i.e., acting a part in an interaction system. To investigate this development this article focuses on the ways in which participation in routinized episodes may shape infant's agentivity in social events. …”
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    Taking Up an Active Role: Emerging Participation in Early Mother–Infant Interaction during Peekaboo Routines
  20. 9520
    “…Increased fecal testing using Fecal Occult Blood Tests (FOBT) or Fecal Immunochemical Tests (FIT) played a prominent role in 2014. The uptick in statewide fecal testing appears driven primarily by a subset of CCOs. …”
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    Does a transition to accountable care in Medicaid shift the modality of colorectal cancer testing?
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