“…Interestingly, OGD/reperfusion injury increased the phosphorylation of ERK1/2 and C3aR inhibition significantly reduced the activation of ERK suggesting that endothelial C3aR may act via ERK signaling. …”
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“…Studies suggest that cancer stem cells (CSCs) are associated with stemness characteristics, providing some support for the concept that CSCs act as osteosclerotic precursors in bone microenvironmental niches. …”
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“…Recently, an increasing amount of studies indicate that the tumor microenvironment plays a pivotal role in tumor malignancy and treatment responses. …”
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“…Instead, other mechanisms appear to be playing important roles, including: (1) reduction of alloreactive CD4(+) effector T-cell proliferation; (2) induced functional impairment of surviving alloreactive CD4(+) and CD8(+) effector T cells; and (3) preferential recovery of CD4(+) regulatory T cells. …”
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“…The human organic anion transporter 3 (OAT3), which is highly expressed in the kidney, plays a critical role in the renal clearance of many drugs. …”
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“…Soil fungi strongly influence ecosystem structure and functioning, playing a key role in many ecological services as decomposers, plant mutualists and pathogens. …”
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“…Cox regression analysis explained that miR-92a expression was associated with the prognosis of patients with NSCLC (HR = 1.8, 95% CI: 1.0–3.2, P = .036). In summary, miR-92a was highly expressed in NSCLC tissues and could act as a prognostic factor for patients with NSCLC. …”
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“…BACKGROUND: Accumulating evidence suggests that N6-methyladenosine (m6A) RNA methylation plays an important role in tumor proliferation and growth. …”
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“…The results showed that: (1) the status of the network reflects the changes of community composition and structure after the decline in large carnivores and other species; (2) with the exception of the Chinese mountain cat and stone marten, the other five medium and small carnivores were located in the network, which played an important role in the complexity of the network and the maintenance of the community; (3) the medium and small carnivores could not take the place of the large carnivores in order to control the population of herbivores, such as Siberian roe deer (Capreolus pygargus) and Himalayan marmot (Marmota himalayana). …”
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“…Paired epistatic interactions, such as those in the stem regions of RNA, play an important role in many biological processes. …”
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“…There is a need to de-stigmatize mental health issues and encourage greater awareness and support from supervisors and colleagues. Leadership can play an important role in mitigating mental health issues, and as such investment in both leadership training and mentorship are important first steps in acting upon our research findings.…”
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“…Age also moderates this mediation, i.e., the older the teenagers are, the weaker is the analyzed mediation effect. …”
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“…INTRODUCTION: Etoposide refers to a derivative of podophyllotoxin, which plays an important role in the treatment of cancer due to its prominent anti-tumor effect. …”
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“…Integral feedback control is known to play a key role in this behaviour. Here, I show that a feedback system involving transcriptional and post-translational regulations of the same executor protein acts as a proportional integral (PI) controller, leading to enhanced transient performances in comparison with a classical integral loop. …”
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“…Alcohol has anxiety-reducing properties and can relieve stress, while at the same time acting as a stressor and activating the body’s stress response systems. …”
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“…WWOX participates in a variety of cellular events and acts as a transducer in the many signal pathways, including TNF, chemotherapeutic drugs, UV irradiation, Wnt, TGF-β, C1q, Hyal-2, sex steroid hormones, and others. …”
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“…Endothelin (ET), originally characterized as a vasoconstrictive peptide, has been found to have many different biological functions, including acting as a local hormonal regulator of pressure, fluid, ions and neurotransmitters in the inner ear. …”
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