“…Furthermore, we show that ALIX recruitment to the membrane orchestrates the downstream assembly of late-acting CHMP4B, CHMP3, and CHMP2A subunits along with the AAA(+) ATPase VPS4B. …”
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“…To develop our program in the simplest way, we work within the construct of a minimal model with gauge-extended sector U (3)_B \times Sp (1)_L \times U (1)_{I_R} \times U (1)_L. The resulting U (1) content gauges the baryon number B, the lepton number L, and a third additional abelian charge I_R which acts as the third isospin component of an SU(2)_R. …”
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“…Angiotensin converting enzyme (ACE) is well known for its dual actions in converting inactive Ang I to active Ang II and degrade active bradykinin (BK), which play an important role in the control of blood pressure. …”
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“…Taken together, our study elucidated a novel HOTAIR /miR-1/CCND1 regulatory axis in which HOTAIR acted as a competing endogenous RNA by sponging miR-1 and upregulated CCND1 expression, thereby facilitating the tumorigenesis of ESCC. …”
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“…Chemical interactions play a fundamental role in the ecology of marine foodwebs. …”
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“…There is increasing evidence that metabotropic GABA(B) receptors are now known to play an important role in modulating the excitability of circuits throughout the brain by directly influencing different types of postsynaptic glutamate receptors. …”
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“…An important role in this developmental program is played by serotonergic projections that, acting on temporally and spatially regulated postsynaptic receptors, induce and modulate the phases of synaptic formation and maturation. …”
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“…These are attractive drug targets because they are highly conserved among coronaviruses and play vital structural/catalytic roles in viral proteins indispensable for virus replication. …”
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“…Some unresolved questions in poultry science were addressed: what determines the yield of chick embryos or hatchlings; what kind of influence does egg yolk content have on embryonic development; and how to detect eggs producing super grade chicks? Since the yolk acts as a vital energy and nutrient reservoir for embryos, we hypothesized that a higher yolk content of similar sizes eggs would play an important role in embryo or chick viability during incubation, as well as at hatch. …”
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“…However, the signaling pathways controlling stomata development are not fully understood(1,2), although Mitogen Activated Protein Kinase (MAPK) signaling is known to play key roles. …”
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“…As IFNL receptors show a more restricted tissue expression than receptors for other classes of IFNs, IFNL treatment has reduced side effects compared to the classical type I IFN treatment. In HCV therapy, however, IFNL will likely not play an important role as highly effective direct acting antivirals (DAA) exist. …”
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“…The interactions between neuronal, glial, and vascular cells play a key role in regulating blood flow in the retina. …”
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“…Approved medications, including long-acting injectable naltrexone, can transform the treatment of individuals with opioid use disorder (OUD). …”
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“…The detected alterations of the linguistic material in Arabic newspapers play an indicator role. The currently proposed approach acts in an “online” fashion and uses pre-trained vector representations of Arabic words. …”
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“…Then, we describe in detail experimental data, obtained in vitro and in vivo in animal models, which support a potential role of neuroinflammation in such a link, and the specific molecules (i.e., released cytokines, glial receptors, including pattern recognition receptors and others) whose expression is altered by LC degeneration and might play a key role in AD/PD pathogenesis. …”
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“…Scaffolds play an essential role in the success of tissue engineering approaches. …”
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“…However, in primary neuroblastomas, RUNX3 acts as a tumor-suppressor, whereas RUNX1 bifunctionally regulates cell proliferation according to the characterized genetic and epigenetic backgrounds, including MYCN oncogenesis. …”
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“…Here, we demonstrate that a 295T>C variant in the human ZRS, previously thought to represent a neutral polymorphism, acts as a dominant allele with reduced penetrance. …”
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