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  1. 9661
    “…Toll-like receptors (TLRs) are a family of pattern recognition receptors that acts as sentinels of the immune system against the invading pathogens. …”
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    Identification and Expression Profiling of Toll-Like Receptors of Brown Trout (Salmo trutta) during Proliferative Kidney Disease
  2. 9662
    “…The unsupervised clustering of tumors using the mRNA levels of autophagy-related genes revealed the existence of two major clusters: microsatellite instability (MSI)-enriched and -depleted. In cluster 1 (MSI-depleted), ATG9B and LAMP1 genes were the most prominently expressed, whereas cluster 2 (MSI-enriched) was characterized by DRAM1 upregulation. …”
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    Transcriptomic Profiling for the Autophagy Pathway in Colorectal Cancer
  3. 9663
    “…Plankton microorganisms play central roles in the marine food web and global biogeochemical cycles, while their distribution and abundance are affected by environmental variables. …”
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    Bacterial and Protistan Community Variation across the Changjiang Estuary to the Ocean with Multiple Environmental Gradients
  4. 9664
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    The Effect of Sleep Quality and Quantity on Athlete's Health and Perceived Training Quality
  5. 9665
    “…Here we describe how unexpanded CGG repeats and their translation play conserved roles in regulating FMRP synthesis. …”
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    A native function for RAN translation and CGG repeats in regulating Fragile X protein synthesis
  6. 9666
    por Barriocanal, Marina, Fortes, Puri
    Publicado 2017
    “…Interestingly, several lncRNAs deregulated in HCV-infected cells described so far play proviral or antiviral functions by acting as positive or negative regulators of the IFN system, while others help in the development of liver cirrhosis and HCC. …”
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    Long Non-coding RNAs in Hepatitis C Virus-Infected Cells
  7. 9667
    “…Synaptophysins 1 and 2 and synaptogyrins 1 and 3 constitute a major family of synaptic vesicle membrane proteins. …”
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    Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts
  8. 9668
    por Qin, Qi, Wang, Meng, Yin, Yunsi, Tang, Yi
    Publicado 2022
    “…Microglia, which are intrinsic immune cells in the central nervous system, play important regulatory roles in the process of synapse formation. …”
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    The Specific Mechanism of TREM2 Regulation of Synaptic Clearance in Alzheimer’s Disease
  9. 9669
    “…Drosophila melanogaster Polo and its human orthologue Polo-like kinase 1 fulfill essential roles during cell division. …”
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    Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis
  10. 9670
    por Shi, Yue, Liu, Chong
    Publicado 2021
    “…BACKGROUND: Breast cancer (BC) is one of the major malignancies worldwide. Circular ribonucleic acids (circRNAs) are a class of conserved ribonucleic acid (RNA) molecules that play important roles in various diseases. …”
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    Circular RNA hsa_circ_0043278 inhibits breast cancer progression via the miR-455-3p/EI24 signalling pathway
  11. 9671
    “…DISCUSSION: We found mixed evidence for head and neck characteristics acting as risk factors for and protective factors against mTBI and increased susceptibility to head impacts. …”
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    Head and Neck Characteristics as Risk Factors For and Protective Factors Against Mild Traumatic Brain Injury in Military and Sporting Populations: A Systematic Review
  12. 9672
    “…CONCLUSION: VEGFA/PI3K/AKT signalling may play significant roles in the pathogenesis of IMN, which may provide new targets for the treatment of IMN. …”
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    VEGFA promotes the occurrence of PLA2R-associated idiopathic membranous nephropathy by angiogenesis via the PI3K/AKT signalling pathway
  13. 9673
    “…BACKGROUND: Randomised trials play a vital role in underpinning evidence-based care. …”
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    Feasibility, effectiveness and costs of a decision support intervention for consultees and legal representatives of adults lacking capacity to consent (CONSULT): protocol for a randomised Study Within a Trial
  14. 9674
    “…In the present paper, a total of 24 (23 novel) hexacyclic pyrazolamide derivatives were designed and synthesized by reducing the heptacycle and inserting small flexible linkers on the basis of the previously discovered dual-target compound D-27 acting simultaneously on EcR and Ostrinia furnacalis chitinase (OfChtI). …”
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    A Potential Lead for Insect Growth Regulator: Design, Synthesis, and Biological Activity Evaluation of Novel Hexacyclic Pyrazolamide Derivatives
  15. 9675
    “…Children completed self-report questionnaires for assessing (1) neuroticism and behavioral inhibition as indicators of general vulnerability (2) worry and rumination which are two important manifestations of repetitive negative thoughts, and (3) emotional problems (i.e., anxiety, depression, and sleep difficulties). …”
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    The Role of Repetitive Negative Thoughts in the Vulnerability for Emotional Problems in Non-Clinical Children
  16. 9676
    “…Toxin-antitoxin (TA) systems play diverse physiological roles, such as plasmid maintenance, growth control, and persister cell formation, but their involvement in bacterial pathogenicity remains largely unknown. …”
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    Autoregulation and Virulence Control by the Toxin-Antitoxin System SavRS in Staphylococcus aureus
  17. 9677
    “…CONCLUSIONS: This is the first report showing that PDF is over-expressed in breast, colon, and lung cancers, and the first evidence that the MEK/ERK pathway plays a role in regulating the expression of PDF and MAP1D. …”
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    Overexpression of peptide deformylase in breast, colon, and lung cancers
  18. 9678
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    Neighbourhood green space, physical function and participation in physical activities among elderly men: the Caerphilly Prospective study
  19. 9679
    por Zhang, Tuo, Zhang, Yao, Sui, Dexin, Hu, Jian
    Publicado 2023
    “…Zrt-/Irt-like protein (ZIP) divalent metal transporters play a central role in maintaining trace element homeostasis. …”
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    High-resolution structure of a mercury cross-linked ZIP metal transporter reveals delicate motions and metal relay for regulated zinc transport
  20. 9680
    “…Meristemoids, which possess stem cell-like properties, have been recognized to play important roles in leaf growth. We have recently reported that the Arabidopsis F-box protein STERILE APETALA (SAP)/SUPPRESSOR OF DA1 (SOD3) promotes meristemoid proliferation and regulates organ size by influencing the stability of the transcriptional regulators PEAPODs (PPDs). …”
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    STERILE APETALA modulates the stability of a repressor protein complex to control organ size in Arabidopsis thaliana
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