“…Metabolic pathways such as glycolysis or oxidative phosphorylation play a key role in regulating macrophage function during inflammation and tissue repair. …”
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“…The relative expression levels of PsSWEET1 and PsSWEET9 were obviously higher in ripened fruit than the ones in other developmental stages, suggesting their possible roles in the transport and accumulation of sugars in plum fruit. …”
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“…Major morphogens like Wnts play critical roles in embryonic development and they are also important in maintaining tissue homeostasis. …”
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“…Trans-acting genetic variants play a substantial, albeit poorly characterized, role in the heritable determination of gene expression. …”
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“…We demonstrate that the Δrad4/cdc20-1 double mutant is defective in double strand break repair by way of a plasmid end-joining assay, indicating that Rad4 acts to ensure that damaged DNA is repaired via a Cdc20-mediated mechanism. …”
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“…Fed9 specifically interacts with the Flv3 flavodiiron protein acting in the photoreduction of O(2) to H(2)O.…”
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“…Some circRNAs are believed to fulfill a variety of functions inside the cell mainly by acting as microRNAs (miRNAs) or RNA-binding proteins (RBPs) sponges. …”
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“…The NOD‐like receptor family pyrin domain containing 6 (NLRP6), a member of the NOD‐like receptor (NLR) family, acts as a cytosolic innate immune sensor that recognizes microbe‐associated molecular patterns. …”
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“…At physiological levels, signaling through this receptor promotes muscle development in growing embryos and proper angiogenesis in regenerating adult muscle.(1,2) However, both increased PDGF ligand abundance and enhanced PDGFRα pathway activity cause pathological fibrosis.(3,4) This excessive collagen deposition, which is seen in aged and diseased muscle,(5–7) interferes with proper muscle function and limits the effectiveness of gene- and cell-based therapies for muscle disorders.(8,9) Although compelling evidence exists for the role of PDGFRα in fibrosis, little is known about the cells through which this pathway acts. …”
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“…Nonetheless, host factors, e.g. age, ethnicity, insulin resistance, and genetic variations, may also play important roles in the SVR in CHC patients treated with SOC. …”
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“…IL6, TNF, IL1B, PTGS2, ESR1, and PPARG with the highest degree from PPI network were successfully docked with 19 core components of HQD, respectively. …”
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“…Importantly, proteins driving MET signaling were less abundant in COMT overexpressing cells, and pull-down confirmed interaction between COMT and Kunitz-type protease inhibitor 2 (SPINT2), a negative regulator of MET (log2FC = 5.10, q = 1.04(−7)). In conclusion, COMT may act as tumor suppressor in ER dependent BC not only by detoxification of catechol estrogens but also by suppressing cell invasion and interplay with MET pathway.…”
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“…BACKGROUND: We previously reported that osteopontin plays an essential role in accelerating both reparative fibrosis and clearance of dead cells (efferocytosis) during tissue repair after myocardial infarction (MI) and galectin‐3(hi)CD206(+) macrophages is the main source of osteopontin in post‐MI heart. …”
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“…Our previous studies have shown that the overexpression of the other negative co-stimulatory molecule (programmed death cell-PD-1) and its ligand-1 (PD-L1) is closely related to iPAH and the presence of Epstein-Barr virus (EBV) reactivation markers. …”
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“…We investigated whether the determinants competence and warmth, known to influence interpersonal trust development, influence trust development in HRI, and what role anthropomorphism plays in this interrelation. In two online studies with 2 × 2 between-subjects design, we investigated the role of robot competence (Study 1) and robot warmth (Study 2) in trust development in HRI. …”
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“…Mitochondrial dysfunction plays a major role in the pathogenesis of cardiovascular diseases. …”
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“…Although the cDNA array highlights gene types (the tested gene and any close family members), trans-acting factors or metabolic bottlenecks seem to play the major role in controlling heritable variation of gene expression related to cell-wall digestibility, since no in silico mapped ESTs were in the same location as their own eQTL. …”
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“…BACKGROUND: Health care providers play a significant role in large scale health emergency planning, detection, response, recovery and communication with the public. …”
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“…Results with the Epley adjectives indicated that participants were more willing to attribute humanlike behavioral traits to the nonhumanoid rather than the humanoid robot, F(1,91)=5.76, P=.02. The Fussel adjective checklist results showed that subjects were more willing to attribute humanlike social qualities to the remote controlled than the autonomous robot, F(1,91)=5.30, P=.02. …”
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