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  1. 9701
    “…For example, information regarding the effect of wild boar on soil fungi for management application is lacking. Soil fungi play a fundamental role in ecosystems, driving essential ecological functions; acting as mycorrhizal symbionts, sustaining plant nutrition and providing defense; as saprotrophs, regulating the organic matter decomposition; or as plant pathogens, regulating plant fitness and survival. …”
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    Wild Boar Effects on Fungal Abundance and Guilds from Sporocarp Sampling in a Boreal Forest Ecosystem
  2. 9702
    “…BACKGROUND: Normal male puberty begins after 9 years of age with a concurrent rise in luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These play distinct roles, with LH acting on Leydig cells to stimulate testosterone and secondary sex characteristics, while FSH promotes testicular growth by stimulating the maturation of seminiferous tubules. …”
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    PMON325 Rare Presentation of Precocious Puberty Secondary to LH-Secreting Adenoma
  3. 9703
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    Mapping social accountability actors and networks and their roles in water, sanitation and hygiene (WASH) in childcare centres within Nairobi’s informal settlements: A governance diaries approach
  4. 9704
    “…Moreover, ISG20 was involved in regulating CX3CL1 production. In addition to regulating antiviral innate immunity, ISG20 may act as a mediator of CX3CL1 production, thereby inducing glomerular inflammation, particularly in patients with LN.…”
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    Expression of interferon-stimulated gene 20 (ISG20), an antiviral effector protein, in glomerular endothelial cells: possible involvement of ISG20 in lupus nephritis
  5. 9705
    “…From this perspective, it is conceivable that central venous pressure (CVP) plays a more important role in determination of capillary perfusion. …”
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    Elevated central venous pressure is associated with impairment of microcirculatory blood flow in sepsis: a hypothesis generating post hoc analysis
  6. 9706
    “…Background: Microcirculation plays an important role in the physiology of cardiovascular health. …”
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    Retinal Microvascular Responses to Short-Term Changes in Particulate Air Pollution in Healthy Adults
  7. 9707
    “…OBJECTIVES: Oxidative stress plays a major role in the onset and progression of involutional osteoporosis. …”
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    Parathyroid hormone-related protein exhibits antioxidant features in osteoblastic cells through its N-terminal and osteostatin domains
  8. 9708
    “…METHODS: We conducted a comprehensive data analyses on 7 microarray datasets in peripheral blood mononuclear cells (PBMCs) from patients with CKD and ESRD from NCBI-GEO databases, where we examined the expressions of 2641 secretome genes (SG). RESULTS: 1) 86.7% middle class (molecular weight >500 Daltons) uremic toxins (UTs) were encoded by SGs; 2) Upregulation of SGs in PBMCs in patients with ESRD (121 SGs) were significantly higher than that of CKD (44 SGs); 3) Transcriptomic analyses of PBMC secretome had advantages to identify more comprehensive secretome than conventional secretomic analyses; 4) ESRD-induced SGs had strong proinflammatory pathways; 5) Proinflammatory cytokines-based UTs such as IL-1β and IL-18 promoted ESRD modulation of SGs; 6) ESRD-upregulated co-stimulation receptors CD48 and CD58 increased secretomic upregulation in the PBMCs, which were magnified enormously in tissues; 7) M1-, and M2-macrophage polarization signals contributed to ESRD- and CKD-upregulated SGs; 8) ESRD- and CKD-upregulated SGs contained senescence-promoting regulators by upregulating proinflammatory IGFBP7 and downregulating anti-inflammatory TGF-β1 and telomere stabilizer SERPINE1/PAI-1; 9) ROS pathways played bigger roles in mediating ESRD-upregulated SGs (11.6%) than that in CKD-upregulated SGs (6.8%), and half of ESRD-upregulated SGs were ROS-independent. …”
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    End-stage renal disease is different from chronic kidney disease in upregulating ROS-modulated proinflammatory secretome in PBMCs - A novel multiple-hit model for disease progression
  9. 9709
    por Valencak, Teresa G, Azzu, Vian
    Publicado 2014
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    Making heads or tails of mitochondrial membranes in longevity and aging: a role for comparative studies
  10. 9710
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    Hepatitis B virus infection and alcohol consumption
  11. 9711
    por Sorrentino, Dario
    Publicado 2017
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    Microbial dysbiosis in spouses of ulcerative colitis patients: Any clues to disease pathogenesis?
  12. 9712
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    FOXP3 and Tip60 Structural Interactions Relevant to IPEX Development Lead to Potential Therapeutics to Increase FOXP3 Dependent Suppressor T Cell Functions
  13. 9713
    “…Mitochondria play a crucial role in the regulation of cellular metabolism and signalling. …”
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    Mitochondria- and ER-associated actin are required for mitochondrial fusion
  14. 9714
    “…CrmA, however, did not inhibit the activation of nuclear factor (NF)-κB by TNF-α, demonstrating that other signaling functions of TNF-α remain intact and that ceramide does not play a role in the activation of NF-κB. These studies support a distinct role for proteases in the signaling/activation phase of apoptosis acting upstream of ceramide formation.…”
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    Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-α: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway
  15. 9715
    “…The understanding of phenomena involved in the self-assembling of bio-inspired biomaterials acting as three-dimensional scaffolds for regenerative medicine applications is a necessary step to develop effective therapies in neural tissue engineering. …”
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    Glycine-Spacers Influence Functional Motifs Exposure and Self-Assembling Propensity of Functionalized Substrates Tailored for Neural Stem Cell Cultures
  16. 9716
    por Block, Dena Hs, Shapira, Michael
    Publicado 2015
    “…We recently showed that ELT-2 acted as a tissue-specific master regulator, cooperating with 2 transcription factors activated by the p38 pathway, ATF-7 and SKN-1, to control immune responses in the adult C. elegans intestine. …”
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    GATA transcription factors as tissue-specific master regulators for induced responses
  17. 9717
    “…Reactive oxygen species (ROS) are highly reactive chemical species that may cause irreversible tissue damage, and play a critical role in cardiovascular diseases. …”
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    Hydrogen sulfide protects H9c2 cardiomyoblasts against H(2)O(2)-induced apoptosis
  18. 9718
    “…The sperm-specific channel CatSper (cation channel of sperm) controls the intracellular Ca(2+) concentration ([Ca(2+)](i)) and plays an essential role in sperm function. …”
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    The action of physiological and synthetic steroids on the calcium channel CatSper in human sperm
  19. 9719
    “…The direct associations of primary care physician (RRs of 1.32 versus 1.11) and gastroenterologist (RRs of 1.56 versus 1.15) supplies with survival were both stronger in Ontario than California. …”
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    Colon cancer care and survival: income and insurance are more predictive in the USA, community primary care physician supply more so in Canada
  20. 9720
    “…CONCLUSIONS: These results provided compelling evidence that α7nAChR played a pivotal role in regulating the activation and expression of NLRP3 inflammasome in neurons after cerebral I/R. …”
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    Electroacupuncture attenuated cerebral ischemic injury and neuroinflammation through α7nAChR-mediated inhibition of NLRP3 inflammasome in stroke rats
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