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  1. 9821
    “…In biochemical experiments, we show here that the NSD1 mutations Y1971C, R2017Q, and R2017L observed mostly in solid cancers are catalytically inactive suggesting that NSD1 acts as a tumor suppressor gene in these tumors. …”
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  2. 9822
    “…Nrf2 signaling-mediated heme oxygenase (HO)-1 expression acts against oxidants that are thought to play a key role in the pathogenesis of neuronal diseases. …”
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  3. 9823
    “…BACKGROUND: The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin), receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1-6) play critical roles in normal human physiology and disease states. …”
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  4. 9824
  5. 9825
    “…The chemokine receptor CCR5 plays an important role in leukocyte chemotaxis and activation, and also acts as a coreceptor for human and simian immunodeficiency viruses (HIV-1, HIV-2, and SIV). …”
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  6. 9826
    por Mandal, Santi M.
    Publicado 2023
    “…A precise dose of NO may increase oxygenation while also acting as an effective inhibitor of cytokine storm. …”
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  7. 9827
  8. 9828
  9. 9829
    “…Interestingly, α9-nAChR gene expression was also dramatically induced in LM cells, confirming our previous finding that α9-nAChR plays important roles in receptor-mediated carcinogenic signals in human breast cancer development. …”
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  10. 9830
  11. 9831
    “…BACKGROUND: Substantial evidence indicate that long non-coding RNA (lncRNA) and microRNA (miRNA) act as key role in bladder cancer. Differentiation antagonistic ncRNA (DANCR) could be used as a biomarker in the occurrence and development of cancer. …”
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  12. 9832
  13. 9833
    “…The core active ingredients of LS in the treatment of CHD were determined to be ursolic acid, myricetin, and beta-sitosterol. CONCLUSIONS: SL may act on targets such as STAT3, TP53, and VEGFA through tumor necrosis factor (TNF) signaling pathway, interleukin 17A (IL-17A) signaling pathway, AGE-RAGE signaling pathway in diabetic complications, and other related pathways, thereby playing a role in preventing and treating CHD.…”
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  14. 9834
  15. 9835
    por Griesenauer, Brad, Paczesny, Sophie
    Publicado 2017
    “…Il1rl1 (also known as ST2) is a member of the IL-1 superfamily, and its only known ligand is IL-33. …”
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  16. 9836
  17. 9837
  18. 9838
  19. 9839
  20. 9840
    “…BACKGROUND: Parkinson's disease (PD) is a multifactorial disease where environmental factors act on genetically predisposed individuals. Although only 5% of PD manifestations are associated with specific mutations, majority of PD cases are of idiopathic origin, where environment plays a prominent role. …”
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