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  1. 81
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    SMARCC1 Enters the Nucleus via KPNA2 and Plays an Oncogenic Role in Bladder Cancer
  2. 82
    “…PlexinB1 and Sema4D show largely complementary cell distribution in tissues, consistent with the idea that PlexinB1 acts as the receptor for Sema4D in vivo. …”
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    Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis
  3. 83
    “…In this pathway, βarrestin-1 (βarr1) acts as a molecular scaffold to promote the binding and degradation of p53 by the E3-ubiquitin ligase, MDM2. …”
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    βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1
  4. 84
    “…While some invertebrate Dicers act alone during antiviral defense, C. elegans Dicer acts in a complex with a dsRNA binding protein called RDE-4, and an RLR ortholog called DRH-1. …”
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    C. elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA
  5. 85
    “…Taken together, out data indicate that MAZR preferentially acts as a transcriptional repressor in mast cells, however MAZR plays only a minor role in the transcriptional networks that regulate early and late effector functions in mast cells in response to FcεRI stimulation.…”
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    The Transcription Factor MAZR Preferentially Acts as a Transcriptional Repressor in Mast Cells and Plays a Minor Role in the Regulation of Effector Functions in Response to FcεRI Stimulation
  6. 86
    “…Since then, KCC1 has been found to be the most widely distributed KCC isoform and considered to act as a housekeeping membrane protein. …”
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    K(+)-Cl(−) cotransporter 1 (KCC1): a housekeeping membrane protein that plays key supplemental roles in hematopoietic and cancer cells
  7. 87
    “…These results demonstrate that LAG-3 acts synergistically with PD-1 and/or other immunoregulatory genes to prevent autoimmunity in mice.…”
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    PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice
  8. 88
    por Utani, Koichi, Aladjem, Mirit I.
    Publicado 2018
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    Extra View: Sirt1 Acts As A Gatekeeper Of Replication Initiation To Preserve Genomic Stability.
  9. 89
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    Prox1 and FOXC2 Act as Regulators of Lymphangiogenesis and Angiogenesis in Oral Squamous Cell Carcinoma
  10. 90
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    lncRNA VIM-AS1 acts as a prognostic biomarker and promotes apoptosis in lung adenocarcinoma
  11. 91
    por Hirose, Takashi, Horvitz, H. Robert
    Publicado 2014
    “…GCN-1 and ABCF-3 act independently of the anti-apoptotic BCL-2 homolog CED-9 and of transcriptional regulators that upregulate the pro-apoptotic BH3-only gene egl-1. …”
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    The Translational Regulators GCN-1 and ABCF-3 Act Together to Promote Apoptosis in C. elegans
  12. 92
    “…We previously demonstrated that bone morphogenetic proteins (BMPs) induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1. Transcription factors Smads mediate transforming growth factor-β signaling and the ATF/CREB family transcription factor ATF-2 has recently been shown to act as a common target of the Smad and the TAK1 pathways. …”
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    Smads, Tak1, and Their Common Target Atf-2 Play a Critical Role in Cardiomyocyte Differentiation
  13. 93
    por Shea, Nicholas
    Publicado 2023
    “…Carried over to conceptual thought, the model suggests that concepts are ‘plug & play’ devices. The distinctive power of thought-driven simulation derives from the ability of concepts to plug into two kinds of structure at once: the combinatorial structure of a thought at one end and special-purpose structural representations at the other. …”
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    Concepts as plug & play devices
  14. 94
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    NSPc1 is a cell growth regulator that acts as a transcriptional repressor of p21Waf1/Cip1 via the RARE element
  15. 95
    “…These data indicate that MEKK-3 plays an essential role in the SKN-1-dependent signaling pathway involved in oxidative stress resistance and longevity by cooperating with NSY-1.…”
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    MEKK-3 Acts Cooperatively with NSY-1 in SKN-1-Dependent Manner against Oxidative Stress and Aging in Caenorhabditis elegans
  16. 96
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    High Mobility Group Box 1 Influences HSV1716 Spread and Acts as an Adjuvant to Chemotherapy
  17. 97
    “…In contrast, at the CTCF promoter PADI4 acts as a repressor. We propose that the influence of PADI4 on IL6ST transcription plays a role in the control of IL6ST expression during lineage differentiation of hematopoietic stem/progenitor cells. …”
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    PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation
  18. 98
    “…From these results, i.c.v. administered AngII acts on brain AT(1) receptors, thereby inducing the secretion of adrenaline and pressor responses. …”
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    Angiotensin II acting on brain AT(1) receptors induces adrenaline secretion and pressor responses in the rat
  19. 99
    por Kumar, Sujeet, Sharma, Rajendra K.
    Publicado 2015
    “…The observations of an ~3 fold increase in enzymatic efficiency following removal of the N-terminal peptide of hNMT1s indicates that N-terminal amino acids acts as an inhibitory segment and negatively regulate the enzyme activity. …”
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    N-Terminal Region of the Catalytic Domain of Human N-Myristoyltransferase 1 Acts as an Inhibitory Module
  20. 100
    “…Our results demonstrate that MAP4Ks act in parallel to and are partially redundant with MST1/2 in the regulation of LATS1/2 and YAP/TAZ, and establish MAP4Ks as components of the expanded Hippo pathway.…”
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    MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway
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