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10021“…Among the 28 INSs genes screened, ins-1, known to play a significant role in starvation-associated behavior working in AIA is inhibitory to satiety quiescence. …”
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10022“…Overall, our results indicate that PA2577 acts as a repressor of the PA2576 gene coding for the EamA-like transporter and may play a role in the modulation of the cellular response to stress conditions, including antimicrobial peptides, e.g., polymyxin B.…”
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10023“…CONCLUSIONS: NF-κB signaling-associated lncRNAs played an important role in regulating immune microenvironment. …”
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10024por Lejmi, Esma, Bouras, Ilyes, Camelo, Serge, Roumieux, Marie, Minet, Norbert, Leré-Déan, Carole, Merkulova-Rainon, Tatyana, Autret, Gwennhael, Vayssettes, Catherine, Clement, Olivier, Plouët, Jean, Leconte, Laurence“…We previously showed that Netrin-4 acts as an anti-angiogenic factor by inhibiting endothelial cell (EC) functions. …”
Publicado 2014
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10025“…These hypoxia-responsive lncRNAs (HRLs) play pivotal roles in regulating hypoxic gene expression at chromatic, transcriptional, and post-transcriptional levels by acting as effectors of the indirect response to HIF or direct modulators of the HIF-transcriptional cascade. …”
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10026“…The results show that: (1) the coordination state of each region gradually improved during the 2008–2017 period. …”
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10027por Schultz, Julia, Warkus, Jeanette, Wolke, Carmen, Waterstradt, Rica, Baltrusch, Simone“…The mitochondrial elongation factor MiD51 has been proposed to act as an anchor that recruits Drp1 from the cytosol to the outer mitochondrial membrane. …”
Publicado 2020
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10028por Nakano, Yasuhiro, Kashino, Chiaki, Hasegawa, Toru, Iwata, Nahoko, Soejima, Yoshiaki, Suyama, Atsuhito, Yamamoto, Koichiro, Otsuka, Fumio“…In the present study, we investigated the effects of leptin and ghrelin on the ovarian steroidogenesis using primary culture of rat granulosa cells, by focusing on the ovarian bone morphogenetic protein (BMP) system, which plays an important role in follicular development and steroidogenesis and acts as a luteinizing inhibitor. …”
Publicado 2022
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10029por Rhein, Philipp, Desjardins, Eric M., Rong, Ping, Ahwazi, Danial, Bonhoure, Nicolas, Stolte, Jens, Santos, Matthieu D., Ovens, Ashley J., Ehrlich, Amy M., Sanchez Garcia, José L., Ouyang, Qian, Yabut, Julian M., Kjolby, Mads, Membrez, Mathieu, Jessen, Niels, Oakhill, Jonathan S., Treebak, Jonas T., Maire, Pascal, Scott, John W., Sanders, Matthew J., Descombes, Patrick, Chen, Shuai, Steinberg, Gregory R., Sakamoto, Kei“…Herein, we investigated the role that AMPKγ3 plays in mediating skeletal muscle glucose uptake and whole-body glucose clearance in response to small-molecule activators that act on AMPK via distinct mechanisms. …”
Publicado 2021
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10030por Grossini, Elena, De Marchi, Fabiola, Venkatesan, Sakthipriyan, Mele, Angelica, Ferrante, Daniela, Mazzini, Letizia“…Oxidative stress, the alteration of mitochondrial function, and the neurovascular unit (NVU), play a role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. …”
Publicado 2023
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10031“…These drugs also increased the release of acid phosphatase and ribonuclease in 5-h incubations. Desmethylimipramine acted within 1 h to increase acid hydrolase release, but the effect of dichloroisoproterenol developed more slowly and was secondary to a change in cellular content of the hydrolases. …”
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10032por Matulova, Petra, Marini, Victoria, Burgess, Rebecca C., Sisakova, Alexandra, Kwon, Youngho, Rothstein, Rodney, Sung, Patrick, Krejci, Lumir“…We present evidence that Rad54 acts by targeting the Mus81·Mms4 complex to its DNA substrates. …”
Publicado 2009
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10033“…Mss11 has been shown to be a central element of FLO1 and FLO11 gene regulation and acts together with the cAMP-PKA-dependent transcription factor Flo8. …”
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10034“…This study describes a spiking model that self-organizes for stable formation and maintenance of orientation and ocular dominance maps in the visual cortex (V1). This self-organization process simulates three development phases: an early experience-independent phase, a late experience-independent phase and a subsequent refinement phase during which experience acts to shape the map properties. …”
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10035“…RMD is hyper-activated by salt stress and repressed by hydroxyurea-induced DNA damage while SMD is inactivated by salt stress and predominates during DNA damage. Mutations of cis-acting signals that control SMD and RMD rescue numerous growth defects of cells lacking Bdf1p, and show that SMD plays an important role in the DNA damage response. …”
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10036por Parikh, Bijal A., Piersma, Sytse J., Pak-Wittel, Melissa A., Yang, Liping, Schreiber, Robert D., Yokoyama, Wayne M.“…Whereas m157 induced Ly49H-dependent degranulation, efficient cytotoxicity also required either IL-12 or type I interferon (IFN-I) which acted directly on NK cells to produce granzyme B. …”
Publicado 2015
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10037por Lee, Su Yeon, Ju, Min Kyung, Jeon, Hyun Min, Jeong, Eui Kyong, Lee, Yig Ji, Kim, Cho Hee, Park, Hye Gyeong, Han, Song Iy, Kang, Ho Sung“…Necrotic cells release their cellular cytoplasmic contents into the extracellular space, such as high mobility group box 1 (HMGB1), which is a nonhistone nuclear protein, but acts as a proinflammatory and tumor-promoting cytokine when released by necrotic cells. …”
Publicado 2018
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10038por Hurtado-Escobar, Genaro Alejandro, Grépinet, Olivier, Raymond, Pierre, Abed, Nadia, Velge, Philippe, Virlogeux-Payant, Isabelle“…Fimbriae play an important role in adhesion and are therefore essential for the interaction of bacteria with the environments they encounter. …”
Publicado 2019
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10039“…SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factors play critical roles in regulating diverse aspects of plant growth and development, including vegetative phase change, plant architecture, anthocyanin accumulation, lateral root growth, etc. …”
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10040por Huang, Qiang, Shen, Yu-Jie, Hsueh, Chi-Yao, Guo, Yang, Zhang, Yi-Fan, Li, Jiao-Yu, Zhou, LiangEnlace del recurso
Publicado 2021
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