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  1. 10061
    “…Studies on immune-related key cardiac genes after burn injury remain limited. The TLRs act individually or as heterodimers, interacting with adaptor proteins to initiate MyD88 or TICAM1 (TRIF) dependent responses. …”
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    816 Up-regulation of Immune Related Key Genes in Burn Induced Cardiac Dysfunction
  2. 10062
    “…HLA-G is a nonclassical histocompatibility class I molecule that plays a role in immune vigilance in cancer and infectious diseases. …”
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    Differentially Expressed Bone Marrow microRNAs Are Associated With Soluble HLA-G Bone Marrow Levels in Childhood Leukemia
  3. 10063
    “…The enzyme, which is a component of the tricarboxylic acid cycle, acts as a tumour suppressor. To evaluate fumarate hydratase in respective sporadic tumours, we analysed a series of 26 leiomyosarcomas and 129 uterine leiomyomas (from 21 patients) for somatic mutations in fumarate hydratase and allelic imbalance around 1q43. …”
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    Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas
  4. 10064
    “…Ascorbate (Asc) is a multifunctional metabolite, acting as an antioxidant and enzymatic cofactor involved in multiple cellular processes. …”
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    Genome and Transcriptome Analyses of Genes Involved in Ascorbate Biosynthesis in Pepper Indicate Key Genes Related to Fruit Development, Stresses, and Phytohormone Exposures
  5. 10065
    “…The RNA-binding protein TIAR is an mRNA-binding protein that acts as a translational repressor, particularly important under conditions of cellular stress. …”
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    Distinct binding properties of TIAR RRMs and linker region
  6. 10066
    “…Our results suggest that changes in both cortisol and testosterone could play a destabilizing role in financial markets through increased risk taking behaviour, acting via different behavioural pathways.…”
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    Cortisol and testosterone increase financial risk taking and may destabilize markets
  7. 10067
    “…In summary, our results highlight the complexity of cereulide biosynthesis and reveal multiple levels of toxin formation control. ces operon internal genes were shown to play a pivotal role by acting at different levels of toxin production, thus complementing the action of the chromosomal key transcriptional regulators AbrB and CodY.…”
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    Ces locus embedded proteins control the non-ribosomal synthesis of the cereulide toxin in emetic Bacillus cereus on multiple levels
  8. 10068
    “…As the MK2 cascade directly regulates tumour necrosis factor alpha (TNFα) production, this review will examine the evidence that the release of TNFα acts to regulate glutamate receptor expression and therefore may play a functional role in the impairment of GI-mGluR-dependent LTD and the cognitive deficits observed in MK2/3 double knockout animals. …”
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    Does the MK2-dependent Production of TNFα Regulate mGluR-dependent Synaptic Plasticity?
  9. 10069
    “…Increasing evidence has indicated that lncRNAs acting as competing endogenous RNAs (ceRNAs) play crucial roles in tumorigenesis, metastasis and diagnosis of cancer. …”
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    Construction of differential mRNA-lncRNA crosstalk networks based on ceRNA hypothesis uncover key roles of lncRNAs implicated in esophageal squamous cell carcinoma
  10. 10070
    “…Oncogenic mutations of RAS genes, found in about 30% of human cancers, are considered to play important roles in cancer development. However, oncogenic RAS can also induce senescence in mouse and human normal fibroblasts. …”
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    Induction of non-apoptotic programmed cell death by oncogenic RAS in human epithelial cells and its suppression by MYC overexpression
  11. 10071
    “…Accordingly, purinergic receptor actions, acting as either ion channels (P2X) or G protein-coupled receptors (GCPRs) (P1, P2Y), target diverse downstream effectors, and substrates to regulate vascular smooth muscle function and vascular reactivity. …”
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    Purinergic Signaling During Hyperglycemia in Vascular Smooth Muscle Cells
  12. 10072
    “…While there is strong evidence that mechanotransduction pathways that stimulate protein synthesis play a key role in regulation of muscle mass, there are likely additional mechano-sensitive mechanisms important for controlling functional muscle adaptation. …”
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    LINCing Nuclear Mechanobiology With Skeletal Muscle Mass and Function
  13. 10073
    “…However, numerous studies indicate that G proteins also play noncanonical roles at unique intracellular locations. …”
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    Gβγ regulates mitotic Golgi fragmentation and G2/M cell cycle progression
  14. 10074
    “…Increasing evidence indicates that miRNAs play crucial regulatory roles in various physiological processes of insects, including systemic metabolism. …”
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    miR-275/305 cluster is essential for maintaining energy metabolic homeostasis by the insulin signaling pathway in Bactrocera dorsalis
  15. 10075
    “…The BM-based net ecosystem production (NEP) was 0.96 tC ha(−1) yr(−1). The EC-based estimates of the average annual gross primary productivity (GPP), ecosystem respiration (R(eco)), and net ecosystem carbon exchange (NEE) were 6.84, 5.54, and −1.30 tC ha(−1) yr(−1), respectively, from May 2013 to December 2015, indicating that this savanna ecosystem acted as an appreciable carbon sink. …”
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    Eddy covariance and biometric measurements show that a savanna ecosystem in Southwest China is a carbon sink
  16. 10076
    por Qi, Huayu
    Publicado 2016
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    RNA-binding proteins in mouse male germline stem cells: a mammalian perspective
  17. 10077
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    AU-rich element-binding proteins in colorectal cancer
  18. 10078
    “…We find mutations in known resistance genes (FUR1 and FCY2) and in a gene UXS1, previously shown to encode an enzyme that converts UDP-glucuronic acid to UDP-xylose for capsule biosynthesis, but not known to play a role in 5FC metabolism. …”
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    5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus
  19. 10079
    “…Given that sphingolipid metabolites play a crucial role in the regulation of stress tolerance and longevity of yeast cells, our data provide a model in which Sch9 regulates the latter phenotypes by acting not only as an effector but also as a regulator of sphingolipid metabolism.…”
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    The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae
  20. 10080
    “…We propose that in response to CED-1 signaling, CHC-1 is recruited to the phagocytic cup through EPN-1 and acts as a scaffold protein to organize actin remodeling. …”
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    Phagocytic receptor signaling regulates clathrin and epsin-mediated cytoskeletal remodeling during apoptotic cell engulfment in C. elegans
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