“…In the present study, we observed that the production of leukotriene B(4) (LTB(4)) and 12(S)-hydroxyeicosatetraenoic acid (HETE), inflammatory lipid mediators acting on LTB(4) receptors (BLT1 and BLT2), was significantly upregulated in peritoneal lavage fluid (PF) and serum from an LPS-induced endotoxic shock mouse model. …”
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“…Expression levels, intrinsic anti-nucleosomal sequences, and trans-acting chromatin modifiers all play important, complementary, and evolvable roles in determining NFRs. …”
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“…Our contemporary political order is, in part, characterized by sovereign states acting either in opposition or cooperation with other sovereign states. …”
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“…Invisibility is classified as the dialectical counterpart of visibility, i.e., as a lack of sense whereby the dynamics of perpetual asking, of coping with each other and of improvements in interpretation are brought into play. …”
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“…Histone acetylation is a dynamic modification process co-regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs). Although HDACs play vital roles in abiotic or biotic stress responses, their members in Triticum aestivum and their response to plant viruses remain unknown. …”
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“…Growth-regulating factors (GRFs) are plant-specific transcription factors that play an important role in plant growth and development. …”
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“…Passive antibody-based therapies could play a role in the treatment of monkeypox, either as a temporizing role amid a shortfall in vaccines and antivirals or a complementary role to direct-acting antivirals. …”
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“…Amino acid transporters (AATs) are integral membrane proteins and play important roles in plant growth and development as well as environmental responses. …”
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“…Substance P, acting via its neurokinin 1 receptor (NK1 R), plays an important role in mediating a variety of inflammatory processes. …”
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“…Using a murine air pouch model of inflammation with LPS as an inflammation inducer, we demonstrate that isoenzymes of the neuraminidase family (NEU1, 3, and 4) play essential roles in these processes by acting as positive or negative regulators of leukocyte infiltration. …”
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“…The results reveal that ARP3/DIS1 acts in root gravitropism by affecting amyloplast sedimentation and PIN-mediated polar auxin transport through regulation of PIN protein trafficking.…”
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“…COI1 acts as multi-component signaling hub that binds with each component. …”
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“…Upon pathogen infections, elevated level of SA promotes massive transcriptional reprogramming in which Non-expresser of PR genes 1 (NPR1) acts as a central hub and transcriptional coactivator in defense responses. …”
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“…CONCLUSIONS: Mitochondrial dynamics play a key role in early corneal fibrogenesis, acting together with profibrotic signaling. …”
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“…Human ADAR3 is a catalytically inactive member of the Adenosine Deaminase Acting on RNA (ADAR) protein family, whose active members catalyze A-to-I RNA editing in metazoans. …”
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“…In particular, in order to increase survival, cancer cells: (a) counteract the accumulation of ceramide that is endowed with pro-apoptotic potential and is induced by many drugs; (b) increase the synthesis of sphingosine-1-phosphate and glucosylceramide that are pro-survivals signals; (c) modify the synthesis and the metabolism of complex glycosphingolipids, particularly increasing the levels of modified species of gangliosides such as 9-O acetylated GD3 (αNeu5Ac(2-8)αNeu5Ac(2-3)βGal(1-4)βGlc(1-1)Cer) or N-glycolyl GM3 (αNeu5Ac (2-3)βGal(1-4)βGlc(1-1)Cer) and de-N-acetyl GM3 (NeuNH(2)βGal(1-4)βGlc(1-1)Cer) endowed with anti-apoptotic roles and of globoside Gb3 related to a higher expression of the multidrug resistance gene MDR1. …”
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“…We hypothesize that there may be a compensatory increase in lower extremity injury rates as players act to avoid head-to-head contact and comply with instated rules. …”
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