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  1. 10121
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    DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy
  2. 10122
    “…We have recently shown that, contrary to Escherichia coli, the fructose-dependent transcriptional regulator FruR acts as an activator of the fru operon in V. cholerae and binding of the FruR–fructose 1-phosphate (F1P) complex to an operator facilitates RNA polymerase (RNAP) binding to the fru promoter. …”
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    HPr prevents FruR-mediated facilitation of RNA polymerase binding to the fru promoter in Vibrio cholerae
  3. 10123
    “…Microglial activation and inflammation are associated with progressive neuronal apoptosis in neurodegenerative disorders such as Parkinson’s disease (PD). γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system, has recently been shown to play an inhibitory role in the immune system. Tiagabine, a piperidine derivative, enhances GABAergic transmission by inhibiting GABA transporter 1 (GAT 1). …”
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    Tiagabine Protects Dopaminergic Neurons against Neurotoxins by Inhibiting Microglial Activation
  4. 10124
    “…The effects of d-amphetamine (0.4 mg kg(−1) i.p.), quinpirole (0.08 mg kg(−1) i.p.), and SKF-81297 (0.4 mg kg(−1) s.c.) were compared between intact rats and rats whose 5-HTergic pathways had been destroyed by intra-raphe injection of 5,7-dihydroxytryptamine. …”
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    Attenuation of the effects of d-amphetamine on interval timing behavior by central 5-hydroxytryptamine depletion
  5. 10125
    “…It is now emerging that long noncoding RNAs (lncRNAs) play key regulatory roles in these adverse responses: lncRNA TUG1, AK098656, TRPV1, GAS5, Giver, and Lnc-Ang362 have been indicated in hypertension-related vascular remodeling, H19, TUG1, UCA1, MEG3, APPAT, and lincRNA-p21 in atherosclerosis (AS), and HIF1A-AS1 and Lnc-HLTF-5 in aortic aneurysm (AA). …”
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    Long Noncoding RNAs in Pathological Cardiac Remodeling: A Review of the Update Literature
  6. 10126
    “…BACKGROUND: CD5L (CD5 molecular-like) plays an important role in lipid metabolism and immune regulation. …”
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    Role of CD5 molecular-like on hepatocellular carcinoma
  7. 10127
    “…However, the COVID-19 infection may have played a part in the emergence of cardiac alterations. …”
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    Myocarditis induced by clozapine and COVID-19 infection: a case report
  8. 10128
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    Screen-Time Weight-loss Intervention Targeting Children at Home (SWITCH): a randomized controlled trial
  9. 10129
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    Narrating the journey of sustained recovery from substance use disorder
  10. 10130
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    Evaluation of an eHealth intervention aiming to promote healthy food habits from infancy -the Norwegian randomized controlled trial Early Food for Future Health
  11. 10131
    “…The co-treatment of LPS and pHis further confirmed that pHis played its role in inhibiting LPS-induced sperm apoptosis. …”
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    Implication of Polyhistidine, a Novel Apoptosis Inhibitor, in Inhibiting Lipopolysaccharide-Induced Apoptosis in Boar Sperm
  12. 10132
    “…Pharmacologically, SKK played a significant role in modulating CCl(4) induced hepatic injuries in the Wistar rats at a higher dose. …”
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    Polyherbal Medicine Divya Sarva-Kalp-Kwath Ameliorates Persistent Carbon Tetrachloride Induced Biochemical and Pathological Liver Impairments in Wistar Rats and in HepG2 Cells
  13. 10133
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    The reciprocal effects of physical activity and happiness in adolescents
  14. 10134
    “…In conclusion, our results suggested that two functional promoter polymorphisms of IL-17A, i.e., rs8193036 and rs8193037, were associated with the EGFR mutation status and progression in LUAD patients, indicating that these two genetic variants might act as possible markers for predicting patients’ clinical prognoses.…”
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    Potential Impacts of Interleukin-17A Promoter Polymorphisms on the EGFR Mutation Status and Progression of Non-Small Cell Lung Cancer in Taiwan
  15. 10135
    “…OBJECTIVE: Cav3.2, a T-type low voltage-activated calcium channel widely expressed throughout the central nervous system, plays a vital role in neuronal excitability and various physiological functions. …”
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    Targeting the T-type calcium channel Cav3.2 in GABAergic arcuate nucleus neurons to treat obesity
  16. 10136
    “…Somatic reprogramming induced by defined transcription factors is a low efficiency process that is enhanced by p53 deficiency (1-5). To date, p21 is the only p53 target shown to contribute to p53 repression of iPSC (induced pluripotent stem cell) generation (1, 3), suggesting additional p53 targets may regulate this process. …”
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    miR-34 miRNAs provide a barrier for somatic cell reprogramming
  17. 10137
    “…While most of these receptors prevent unwanted/excessive responses of individual effector cells, others play a more general role in immunity, acting as true inhibitory checkpoints controlling both innate and adaptive immunity. …”
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    Inhibitory Receptors and Checkpoints in Human NK Cells, Implications for the Immunotherapy of Cancer
  18. 10138
    “…BACKGROUND: Glucocorticoids (GC) have direct adverse effects on osteocytes, the most abundant bone cell type, and play an important role in osteonecrosis of the femoral head (ONFH). …”
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    Parathyroid Hormone (PTH) Induces Autophagy to Protect Osteocyte Cell Survival from Dexamethasone Damage
  19. 10139
    “…Valsa mali is the causal agent of apple Valsa canker, a destructive disease in East Asia. Effector proteins play important roles in the virulence of phytopathogenic fungi, and we identified five Hce2 domain‐containing effectors (VmHEP1, VmHEP2, VmHEP3, VmHEP4 and VmHEP5) from the V. mali genome. …”
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    Hce2 domain‐containing effectors contribute to the full virulence of Valsa mali in a redundant manner
  20. 10140
    “…We evolved 20 replicate populations of otherwise isogenic clonally reproducing ‘snowflake’ yeast (Δace2/∆ace2) and aggregative ‘floc’ yeast (GAL1p::FLO1 /GAL1p::FLO1) with daily selection for rapid growth in liquid media, which favors faster cell division, followed by selection for rapid sedimentation, which favors larger multicellular groups. …”
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    Evolutionary consequences of nascent multicellular life cycles
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