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  1. 10201
    “…Synaptotagmin‐1 acts as the Ca(2+) sensor that triggers exocytosis in a tight interplay with the SNAREs and complexins. …”
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    On the difficulties of characterizing weak protein interactions that are critical for neurotransmitter release
  2. 10202
    “…Through analysis of 35,310 cells, we identified 30 distinct immune cell types, 9 unique tumor populations, 1 cluster of fibroblasts, and 1 cluster of endothelial cells. …”
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    Single-cell RNA sequencing reveals the cellular and molecular heterogeneity of treatment-naïve primary osteosarcoma in dogs
  3. 10203
    “…Sporulation in low-G+C gram-positive bacteria (Firmicutes) is an important survival mechanism that involves up to 150 genes, acting in a highly regulated manner. Many sporulation genes have close homologs in non-sporulating bacteria, including cyanobacteria, proteobacteria and spirochaetes, indicating that their products play a wider biological role. …”
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    Sequence analysis of GerM and SpoVS, uncharacterized bacterial ‘sporulation’ proteins with widespread phylogenetic distribution
  4. 10204
    “…We report that TGF-β does not directly promote Th17 cell differentiation but instead acts indirectly by blocking expression of the transcription factors signal transducer and activator of transcription (STAT) 4 and GATA-3, thus preventing Th1 and Th2 cell differentiation. …”
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    Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation
  5. 10205
    “…Transduction of mechanical stimuli by receptor neurons is essential for senses such as hearing, touch, and pain(1–4). Ion channels play a role in neuronal mechanotransduction in invertebrates(1); however, functional conservation of these ion channels in mammalian mechanotransduction is not observed. …”
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    The role of Drosophila Piezo in mechanical nociception
  6. 10206
    “…RESULTS: Proliferating cell nuclear antigen (PCNA), which acts as a processivity factor for DNA polymerase δ, was identified as an interaction partner. …”
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    Agnoprotein of polyomavirus BK interacts with proliferating cell nuclear antigen and inhibits DNA replication
  7. 10207
    “…The female condom is worn inside the vagina and acts as a barrier to prevent semen getting to the womb. …”
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    Female condom acceptability and use amongst young women in Botswana
  8. 10208
    “…A mechanistic study showed that circNFIC acted as a sponge for miR-658 and competed for binding to miR-658 with UPK1A, leading to increased expression of UPK1A. …”
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    circNFIC suppresses breast cancer progression by sponging miR-658
  9. 10209
    “…ABSTRACT: The deleted in azoospermia-like (DAZL) gene encoding an RNA binding protein is pivotal in gametogenesis in lots of species and also acts as a pre-meiosis marker. The current study was conducted to detect expression profiles and single nucleotide polymorphisms (SNPs) of DAZL in sheep using qPCR, DNA-pooled sequencing, improved multiplex ligase detection reaction (iMLDR(®)) and restriction fragment length polymorphism (RFLP) methods. …”
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    Expression of DAZL Gene in Selected Tissues and Association of Its Polymorphisms with Testicular Size in Hu Sheep
  10. 10210
    por Gour, Shalini, Yadav, Jay Kant
    Publicado 2021
    “…Infection of SARS-CoV-2 to the host cell is characterized by direct translation of positive single stranded (+ ss) RNA to form large polyprotein polymerase 1ab (pp1ab), which acts as precursor for a number of nonstructural and structural proteins that play vital roles in replication of viral genome and biosynthesis of new virus particles. …”
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    Aggregation hot spots in the SARS-CoV-2 proteome may constitute potential therapeutic targets for the suppression of the viral replication and multiplication
  11. 10211
    “…It is found that CO(2) molecule can be chemically and preferably adsorbed on Br-vacancy doped Cs(2)AgBiBr(6) with a negative adsorption energy of −1.16 eV. Studying the CO(2) reduction paths on pure and defect modified Cs(2)AgBiBr(6), Br-vacancy is proved to play a critical role in decreasing the potential determining step energy to 1.25 eV. …”
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    Improving the Catalytic CO(2) Reduction on Cs(2)AgBiBr(6) by Halide Defect Engineering: A DFT Study
  12. 10212
    “…The experiments show that the kinetics of domain growth are significantly affected by the type and molecular structure of the oil (squalene, hexadecane, or decane), with the main contributing factors being the degree of swelling of the bilayer and the changes in line tension induced by the different oils, with smaller domains resulting from systems with smaller values of the line tension. POPC (1-palmitoyl-sn-2-oleoyl-glycero-3-phosphocholine), on the other hand, acts as a line-active hybrid lipid, reducing the domain size when added in small amounts and slowing down domain coarsening. …”
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    Domain Size Regulation in Phospholipid Model Membranes Using Oil Molecules and Hybrid Lipids
  13. 10213
    “…Photoperiod is an important environmental factor that influence seasonal reproduction behavior in bird and GnIH can play a function in this process through the reproductive axis, and some studies suggest that GnIH may have a direct role at the gonadal level. …”
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    Expression of GnIH and its effects on follicle development and steroidogenesis in quail ovaries under different photoperiods
  14. 10214
    “…Both of these pathways play a significant role in the disease. It is possible that the Treg pathway acts as an antagonist to the Th1 and Th17 pathways, which would cause the disease to become more localised. …”
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    A Snapshot of T Cell Subset Cytokines in Pemphigus Vulgaris: A Cross-Sectional Study
  15. 10215
    “…IQGAP2 expression is reduced and plays a tumor suppressor role in most solid cancer types, while IQGAP3 is overexpressed and acts as an oncogene. …”
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    The Antithetic Roles of IQGAP2 and IQGAP3 in Cancers
  16. 10216
    “…Functional analyses in zebrafish and the tunicate Ciona, which has a single GATA4/5/6 homolog, revealed that GATA4/5/6 acts upstream of tbx1 to exert essential and cell-autonomous roles in promoting cardiac and inhibiting pharyngeal mesoderm identity. …”
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    GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fate
  17. 10217
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    Intraventricular IL-17A administration activates microglia and alters their localization in the mouse embryo cerebral cortex
  18. 10218
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    Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variants
  19. 10219
    “…BACKGROUND: Growing evidence shows that interleukin 13 (IL-13) may play an essential role in the development of airway inflammation and bronchial hyper-responsiveness (BHR), two defining features of asthma. …”
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    The effect of IL-13 and IL-13R130Q, a naturally occurring IL-13 polymorphism, on the gene expression of human airway smooth muscle cells
  20. 10220
    por Yang, Xiaoli, Yue, Yan, Xiong, Sidong
    Publicado 2019
    “…Macrophages have been reported to play an important pathological role in driving VMC. …”
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    Dpep2 Emerging as a Modulator of Macrophage Inflammation Confers Protection Against CVB3-Induced Viral Myocarditis
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