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  1. 10261
    “…Insulated caudal bovine IVD were subjected to physiological cyclic uniaxial compression over a range of frequencies (0.1‐15 Hz) and loading durations (1‐10 min) ex vivo, and the temperature rise in the tissue was recorded. …”
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    Viscoelastic heating of insulated bovine intervertebral disc
  2. 10262
    “…The K(+) transporter/high-affinity K(+)/K(+) uptake (KT/HAK/KUP) transporters dominate K(+) uptake, transport, and allocation that play a pivotal role in mineral homeostasis and plant adaptation to adverse abiotic stresses. …”
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    Characterization and Expression of KT/HAK/KUP Transporter Family Genes in Willow under Potassium Deficiency, Drought, and Salt Stresses
  3. 10263
    por Zhang, Zenglin, Liu, Chen, Guo, Yongfeng
    Publicado 2020
    “…Here, we report the characterization of TaSNAC11-4B (Uniprot: A0A1D5XI64), a wheat NAC family member that acts as a functional homolog of AtNAP, a key regulator of leaf senescence in Arabidopsis. …”
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    Wheat Transcription Factor TaSNAC11-4B Positively Regulates Leaf Senescence through Promoting ROS Production in Transgenic Arabidopsis
  4. 10264
    “…To study the effects of oxysterols/sterol sulfates on epigenetic modulators, 12 recombinant epigenetic enzymes were used to determine whether 25HC3S acts as their endogenous ligand. The enzyme kinetic study demonstrated that 25HC3S specifically inhibited DNA methyltransferases (DNMTs), DNMT1, DNMT3a, and DNMT3b with IC(50) of 4.04, 3.03, and 9.05 × 10(−6) M, respectively. …”
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    25-Hydroxycholesterol 3-sulfate is an endogenous ligand of DNA methyltransferases in hepatocytes
  5. 10265
    “…Epigenetic regulation of gene expression is crucial to the determination of cell fate in development and differentiation, and the Polycomb (PcG) and Trithorax (TrxG) groups of proteins, acting antagonistically as complexes, play a major role in this regulation. …”
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    Histone Methylases and Demethylases Regulating Antagonistic Methyl Marks: Changes Occurring in Cancer
  6. 10266
    “…Long noncoding RNAs have been widely accepted to play important roles in acute myocardial infarction (AMI). …”
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    Retracted Article: Long noncoding RNA ANRIL protects cardiomyocytes against hypoxia/reoxygenation injury by sponging miR-195-5p and upregulating Bcl-2
  7. 10267
    “…Hepatotropic viruses also play a role in the development of chronic liver diseases, although their comparative frequency has been decreasing over the last decades. …”
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    Liver Diseases in Latin America: Current Status, Unmet Needs, and Opportunities for Improvement
  8. 10268
    por Ohto, Umeharu
    Publicado 2022
    “…Innate immune pattern recognition receptors (PRRs) play pivotal roles in detection of invading pathogens. …”
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    Activation and regulation mechanisms of NOD-like receptors based on structural biology
  9. 10269
    “…PHYA is involved in starch accumulation in all the examined light conditions, whereas PHYB only exhibits a role under low light intensity (44 ± 1 μmol m(-2) s(-1)) or low R:FR (11.8 ± 0.6). PCA analysis of the metabolic profiles in the mutants and wild type (WT) suggested that PHYB acts as a major regulator of the leaf metabolic status in response to light intensity. …”
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    Phytochrome A and B Regulate Primary Metabolism in Arabidopsis Leaves in Response to Light
  10. 10270
    por Devesa, Jesús
    Publicado 2021
    “…They have been found in GH3 cell cultures where they significantly reduce the expression of gh mRNA and that of pituitary-specific positive transcription factor 1, consequently acting as inhibitors of GH production. …”
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    The Complex World of Regulation of Pituitary Growth Hormone Secretion: The Role of Ghrelin, Klotho, and Nesfatins in It
  11. 10271
    “…The above three branching N-glycan sugar chains, β1-6 GlcNAc branching, bisecting GlcNAc and core fucose (α1-6 fucose), play major roles in cancer invasion and metastasis, the inhibition of cancer metastasis, and antibody-dependent cellular cytotoxicity (ADCC), growth and development, respectively. …”
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    Functional glycomics and evidence for gain- and loss-of-functions of target proteins for glycosyltransferases involved in N-glycan biosynthesis: their pivotal roles in growth and development, cancer metastasis and antibody therapy against cancer
  12. 10272
    “…The policy network comprises mainly national authorities and committees responsible for targeting and policymaking for local implementation, while economic networks are formal and informal actors acting for PPW collection with a recycling contribution of 11.3–64.1%. …”
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    Towards sustainability through the circular economy of plastic packaging waste management in Rayong Province, Thailand
  13. 10273
    “…These findings show that two proteins with similar enzymatic function can play opposing roles in the context of the same disease and pave the way for the use of a new category of epigenetic inhibitors in hematopoietic malignancies.…”
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    Contrasting roles for histone 3 lysine 27 demethylases in acute lymphoblastic leukemia
  14. 10274
    “…The heterojunction built between the ZnO nanoparticle and ZCIS QDs not only extends the light adsorption range by the photocatalyst but also acts to decrease electron/hole recombination. Interestingly, the ZnO/ZCIS composite was found to produce increased amounts of H(2)O(2) and singlet oxygen (1)O(2) compared to ZnO, suggesting that these reactive oxygen species play a key role in the photodegradation mechanism. …”
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    ZnO nanoparticles sensitized by CuInZn(x)S(2+)(x) quantum dots as highly efficient solar light driven photocatalysts
  15. 10275
    “…The albinotic phenotype was likely linked to a cis-regulatory element acting on the mitfa gene and the double-tail mutant was suggested to be caused by a deletion in a zic1/zic4 coenhancer. …”
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    Genomic Basis of Striking Fin Shapes and Colors in the Fighting Fish
  16. 10276
    “…Furthermore, we show that TSLP signals through TSLP receptor–expressing (TSLPR-expressing) DCs to play an unrecognized role in promoting GATA3(+) Tregs expressing a gene signature including ST2, CCR8, ICOS, PD-1, CTLA-4, and OX40 and exhibiting a potent suppressive activity on CD8(+) T cell proliferation and IFN-γ production. …”
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    Keratinocyte-derived cytokine TSLP promotes growth and metastasis of melanoma by regulating the tumor-associated immune microenvironment
  17. 10277
    “…In this work, we developed CORENODE, a computational algorithm for genome-wide transcription network decomposition that identified a transcription factor (TF) tetrad consisting of IRF8, MYB, MEF2C, and MEIS1, regulating MHCII expression in AML cells. We show that reduced MHCII expression at relapse is transcriptionally driven by combinatorial changes in the expression of these TFs, where MYB and IRF8 play major opposing roles, acting independently of the IFNγ/CIITA pathway. …”
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    Transcriptional Plasticity Drives Leukemia Immune Escape
  18. 10278
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    Type 2 immunity-dependent reduction of segmented filamentous bacteria in mice infected with the helminthic parasite Nippostrongylus brasiliensis
  19. 10279
    “…Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a phosphoprotein that plays key, yet poorly defined, roles in both virus genome replication and virion assembly/release. …”
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    Phosphorylation of Serine 225 in Hepatitis C Virus NS5A Regulates Protein-Protein Interactions
  20. 10280
    “…BACKGROUND: The small GTP-binding protein Rab31 plays an important role in the modulation of tumor biological-relevant processes, including cell proliferation, adhesion, and invasion. …”
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    Rab31-dependent regulation of transforming growth factor ß expression in breast cancer cells
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