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  1. 10281
    “…RESULTS: The Cynarine could act on 48 targets of NAFLD, and the role of CASP3, TP53, MMP9, ELANE, NOTCH1 were more important. …”
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    Mechanisms of Cynarine for treatment of non-alcoholic fatty liver disease based on the integration of network pharmacology, molecular docking and cell experiment
  2. 10282
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    Antidepressant treatment response is modulated by genetic and environmental factors and their interactions
  3. 10283
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    Anaplasma marginale and A. phagocytophilum in cattle in Tunisia
  4. 10284
    “…The anti-CD20 Rituximab played an important role in the development of the treatment of iNHL to become FDA approved in 1997. …”
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    Immunotherapy in indolent Non-Hodgkin's Lymphoma
  5. 10285
    “…The disordered microtubule associated Tubulin Polymerization Promoting Protein (TPPP/p25) and the NAD(+)-dependent tubulin deacetylase sirtuin-2 (SIRT2) play key roles in oligodendrocyte differentiation by acting as dominant factors in the organization of myelin proteome. …”
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    Modulation Of Microtubule Acetylation By The Interplay Of TPPP/p25, SIRT2 And New Anticancer Agents With Anti-SIRT2 Potency
  6. 10286
    “…Clinically, lncMMPA expression associates with glycolysis in TAMs and reduced survival of HCC patients. CONCLUSION: LncMMPA plays an important role in regulating HCC malignancy and metabolic reprogramming of miR-548 s/ALDH1A3 pathway. …”
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    Tumor associated macrophages-derived exosomes facilitate hepatocellular carcinoma malignance by transferring lncMMPA to tumor cells and activating glycolysis pathway
  7. 10287
    por Fang, Ting, Ji, Zhe, Lu, Hui, Jiang, Yuanying
    Publicado 2022
    “…POSTER SESSION 1, SEPTEMBER 21, 2022, 12:30 PM - 1:30 PM:   OBJECTIVES: Hyphal formation is an important virulence factor of opportunistic pathogenic fungi and plays a vital role in invasive fungal infections. …”
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    P062 Identification of Octenidine (dihydrochloride) inhibiting fungal filamentation by the repurposing approach
  8. 10288
    “…In agreement, the pharmacological inhibition of Class I HDAC (HDAC1/3) mirrored butyrate's effects, suggesting that butyrate impacts MC function by HDAC1/3 inhibition. …”
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    Epigenetic histone modification by butyrate downregulates KIT and attenuates mast cell function
  9. 10289
    “…The expression of cis-acting genes adjacent to the NTT locus (CTGF, STX7, MYB, BCLAF1, IFNGR1, TNFAIP3, and HIVEP2) was also assessed. …”
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    Long Noncoding RNA NTT Context-Dependently Regulates MYB by Interacting With Activated Complex in Hepatocellular Carcinoma Cells
  10. 10290
    “…Oxidative-independent responses involve DREB/CBF, RAP2 and RAV1 factors acting on DRE/CRT/rav1-like enriched clusters and bZIP factors acting on ABRE-like enriched clusters. …”
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    Transcriptional regulatory network triggered by oxidative signals configures the early response mechanisms of japonica rice to chilling stress
  11. 10291
    “…However, their interdependence and biological relevance when acting as a complex have not been extensively studied. …”
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    Combinatorial activities of SHORT VEGETATIVE PHASE and FLOWERING LOCUS C define distinct modes of flowering regulation in Arabidopsis
  12. 10292
    “…Activation of the aryl hydrocarbon receptor (AhR), which mediates the induction and release of IL22 from immune cells, was also transiently increased with PM exposure. The microbiome plays a major role in maintaining epithelial integrity and immune responses by producing various metabolites that act as ligands for AhR. …”
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    Exposure to combustion derived particulate matter exacerbates influenza infection in neonatal mice by inhibiting IL22 production
  13. 10293
    “…Building on these findings, we established that the conserved RhoGEF Cysts and RhoGEF4 play sequential and distinct roles to couple cytokinesis with de novo junction formation. …”
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    Systematic analysis of RhoGEF/GAP localizations uncovers regulators of mechanosensing and junction formation during epithelial cell division
  14. 10294
    “…Additionally, glutamine, processed by mitochondrial substrate level phosphorylation is emerging as a key role player in the expansion and differentiation of Th1, Th17, ϒδ T cells, and plasmablasts. The role that circulating leukocytes play in acting as bioenergetic biomarkers of diseases such as diabetes suggests that this may also be a tool to detect preclinical SLE. …”
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    Mitochondrial bioenergetic changes in systemic lupus erythematosus immune cell subsets: Contributions to pathogenesis and clinical applications
  15. 10295
    “…Our data show that Syt9 is acts at multiple sites in the retina and suggest that it may play a role in regulating transmission of cone signals by rods.…”
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    SYNAPTOTAGMIN-9 IN MOUSE RETINA
  16. 10296
    “…TGF-β has been known as a classic anti-inflammatory cytokine and controls both initiation and resolution of inflammation by counter-acting inflammatory cytokines. In the present study, to understand the self-protective mechanism, we studied time-dependent change of TNF-α and TGF-β production in microglia phagocytizing opsonized-beads (i.e., polystyrene microspheres). …”
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    Role of TGF-β in Survival of Phagocytizing Microglia: Autocrine Suppression of TNF-α Production and Oxidative Stress
  17. 10297
    “…Biogenic amine receptors play critical roles in regulating behavior and physiology in both vertebrates and invertebrates, particularly within the central nervous system. …”
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    Comprehensive, structurally-informed alignment and phylogeny of vertebrate biogenic amine receptors
  18. 10298
    “…Long noncoding RNAs (lncRNAs) play a crucial role in tumorigenesis. The aim of this study is to identify lncRNA signature that can predict breast cancer patient survival. …”
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    Transcriptome sequencing uncovers a three–long noncoding RNA signature in predicting breast cancer survival
  19. 10299
    por Liang, Ming-Hua, Jiang, Jian-Guo
    Publicado 2017
    “…All promoters of the carotenogenic genes had light-regulated elements and W-box cis-acting elements. Most WRKY transcription factors can bind to the W-box, and play roles in abiotic stress. qRT-PCR analysis showed that salt stress up-regulated both carotenogenic genes and WRKY transcription factors. …”
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    Analysis of carotenogenic genes promoters and WRKY transcription factors in response to salt stress in Dunaliella bardawil
  20. 10300
    “…Prostate cancer (PC) is the second most commonly diagnosed type of cancer in males with 1,114,072 new cases in 2015. The MTHFR enzyme acts in the folate metabolism, which is essential in methylation and synthesis of nucleic acids. …”
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    Genotyping the High Altitude Mestizo Ecuadorian Population Affected with Prostate Cancer
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