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  1. 10321
    por Jansen, Ralf-Peter, Niessing, Dierk
    Publicado 2012
    “…At all steps from transcription to translation, RNA-binding proteins play important roles in determining mRNA function. …”
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    Assembly of mRNA-Protein Complexes for Directional mRNA Transport in Eukaryotes - An Overview
  2. 10322
    “…We show for the first time that cellular Daxx/ATRX chromatin remodelling complexes play essential roles in Ad gene expression and illustrate the importance of early viral proteins to counteract cellular chromatin remodelling.…”
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    Control of human adenovirus type 5 gene expression by cellular Daxx/ATRX chromatin-associated complexes
  3. 10323
    “…Interestingly, four trans-acting small interfering RNAs (tas3-siRNAs) were also found in degradome libraries, three of which perfectly matched their precursors. …”
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    Small RNA and degradome sequencing reveal complex miRNA regulation during cotton somatic embryogenesis
  4. 10324
    “…Filariasis by inducing chronic inflammation and immunopathologic reactions seems to play a major role in infected affective disorders patients by changing levels of cytokines of the Th1 system or indirectly damaging the brain tissue. …”
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    A bipolar disorder patient becoming asymptomatic after adjunctive anti-filiarasis treatment: a case report
  5. 10325
    “…BACKGROUND: MicroRNAs (miRNAs) are a large group of negative gene regulators that potentially play a critical role in tumorigenesis. Increasing evidences indicate that miR-145 acts a tumor suppressor in numerous human cancers. …”
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    MiR-145 inhibits oral squamous cell carcinoma (OSCC) cell growth by targeting c-Myc and Cdk6
  6. 10326
    “…Here, we performed sRNA profiling of F(1) super-hybrid rice LYP9 and its parents using high-throughput sequencing technology, and identified 355 distinct mature microRNAs and trans-acting small interfering RNAs, 69 of which were differentially expressed sRNAs (DES) between the hybrid and the mid-parental value. …”
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    Small RNAs as important regulators for the hybrid vigour of super-hybrid rice
  7. 10327
    “…Cancer stem cells (CSCs) play major roles in cancer initiation, progression, and metastasis. …”
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    PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth
  8. 10328
    “…In this review, we will compare the mechanisms of late gene transcriptional regulation between HSV-1, for which the viral IE transcription factors – especially ICP4 – play an essential role, and the two other subfamilies of herpesviruses, with a particular emphasis on EBV, which has recently been found to code for its own specific TATT-binding protein.…”
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    Herpesvirus Late Gene Expression: A Viral-Specific Pre-initiation Complex Is Key
  9. 10329
    “…PRDM (PRDI‐BF1 and RIZ domain‐containing) proteins constitute a family of zinc finger proteins and play important roles in multiple cellular processes by acting as epigenetic modifiers. …”
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    PRDM5 promotes the proliferation and invasion of murine melanoma cells through up‐regulating JNK expression
  10. 10330
    “…Plant-specific TEOSINTE BRANCHED 1, CYCLOIDEA, and PROLIFERATING CELL FACTORS (TCP) transcription factors play versatile functions in multiple processes of plant growth and development. …”
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    Identification and Transcript Analysis of the TCP Transcription Factors in the Diploid Woodland Strawberry Fragaria vesca
  11. 10331
    “…Furthermore, we identified that miR‐708‐3p inhibits breast cancer cell epithelial‐to‐mesenchymal transition (EMT) by directly targeting EMT activators, including ZEB1, CDH2 and vimentin. Taken together, our findings suggest that miR‐708‐3p acts as a cancer suppressor miRNA and carries out its anticancer function by inhibiting EMT in breast cancer. …”
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    MicroRNA‐708‐3p mediates metastasis and chemoresistance through inhibition of epithelial‐to‐mesenchymal transition in breast cancer
  12. 10332
    “…Prostaglandins are known as arachidonic acid metabolites acting through specific membrane receptors and play an important role in the regulation of osteoblast and osteoclast functions. …”
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    Lights and shadows of NSAIDs in bone healing: the role of prostaglandins in bone metabolism
  13. 10333
    “…F(ST) repeatability was higher among pairs that were further along the speciation continuum (i.e., more reproductively isolated) providing further insight into how genomic differentiation changes with population divergence; early stages of speciation may be dominated by positive selection that is different between pairs but becomes integrated with processes acting according to shared genomic features as speciation proceeds.…”
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    Comparative analysis examining patterns of genomic differentiation across multiple episodes of population divergence in birds
  14. 10334
    “…Taken together, our results demonstrated an antidepressant effect of THSG in a mouse model of MDD for the first time, and oxidative stress and inflammatory pathways were determined to play roles in this effect.…”
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    2,3,5,4′-Tetrahydroxystilbene-2-O-beta-D-glucoside Reverses Stress-Induced Depression via Inflammatory and Oxidative Stress Pathways
  15. 10335
    “…However, much less is known about which FGF receptors (FGFRs) play a role in laterality. Here, we show that the candidate heterotaxy gene FGFR4 is essential for proper organ situs in Xenopus and that frogs depleted of fgfr4 display inverted cardiac and gut looping. …”
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    Candidate Heterotaxy Gene FGFR4 Is Essential for Patterning of the Left-Right Organizer in Xenopus
  16. 10336
    “…Moreover, CRK2 and CRK3 acted as effectors of RAP2.6 and WRKY14, respectively. …”
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    Tyrosine Kinase-Dependent Defense Responses Against Herbivory in Arabidopsis
  17. 10337
    “…LYRM4 gene codifies for ISD11, a small protein (11 kDa) acting as an iron‐sulfur cluster, that has been recently confirmed as a disease‐causing gene for mitochondrial disorders. …”
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    Iron‐sulfur cluster ISD11 deficiency (LYRM4 gene) presenting as cardiorespiratory arrest and 3‐methylglutaconic aciduria
  18. 10338
    “…The result of differential expression gene analysis shows that the overexpression of GmbZIP2 in soybean hairy roots could enhance the expression of the stress responsive genes GmMYB48, GmWD40, GmDHN15, GmGST1 and GmLEA. These results indicate that soybean bZIPs played pivotal roles in plant resistance to abiotic stresses.…”
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    The Soybean bZIP Transcription Factor Gene GmbZIP2 Confers Drought and Salt Resistances in Transgenic Plants
  19. 10339
    “…The transmission cycle involves human (or other mammalian) water contact with surface water contaminated by faeces or urine, as well as specific freshwater snails acting as intermediate hosts. The main disease-causing species are S. haematobium, S. mansoni and S. japonicum. …”
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    Schistosomiasis—from immunopathology to vaccines
  20. 10340
    “…Recent studies have demonstrated that embryonic stem cells (ESCs) are deficient in expressing type I interferons (IFN), the cytokines that play key roles in antiviral responses. …”
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    Dicer represses the interferon response and the double-stranded RNA-activated protein kinase pathway in mouse embryonic stem cells
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