“…Choline is also the precursor for acetylcholine, a neurotransmitter which activates the alpha7 nicotinic acetylcholine receptor (α7nAchR), and also acts as an agonist for the Sigma‐1 R (σ1R). These receptors regulate CNS immune response, and their dysregulation contributes to AD pathogenesis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Stress associated proteins (SAPs) containing A20/AN1 zinc finger domains have emerged as novel regulators of stress responses. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Moreover, our results suggested that BMP9 acted through the Smad1/5/8 signaling pathway. We also produced a novel scaffold that encompasses bio-degradable CHA seeded with recombinant adenoviruses expressing BMP9-transfected rDFCs (Ad-BMP9-transfected rDFCs). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CDC25 phosphatases play a key role in cell cycle transitions and are important targets for cancer therapy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here we report the application of an immunostaining method to illustrate the cleaning mechanism of a nuclease (DNase I) acting upon eDNA. Extending previous work that established a key role for eDNA in anchoring these soil matrixes, this work provides new insights into the presence and effective removal of eDNA deposited on fabrics using high-resolution in-situ imaging. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Finally, our data demonstrates iBAT does not play a role in mediating favorable metabolic effects of FGF21 administration in DIOs housed at 80 °F or 72 °F.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…HET-1A were transfected with interfering RNA (siRNA(CaSR)). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We demonstrated that 3OST2 methylation may play a critical role in the earliest steps of hepatocarcinogenesis and is directly regulated by UHRF1. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: The active ingredients in Jiawei Chaiqin Wendan decoction may regulate the levels of inflammatory factors and neurotransmitters by acting on multiple targets such as IL6, MAPK3, MAPK1, and PTGS2, so as to play a therapeutic role in vestibular migraine.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The airway epithelium regulates responses to aeroallergens, acting as a physical and immunological barrier. In asthma, epithelial barrier function and the expression of adherens junction protein E-cadherin is compromised, but it is unknown whether this is cause or consequence of the disease. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Cav-2 also has dual functions of inhibiting and promoting cancer and can be expressed in combination with Cav-1 or play a regulatory role alone. Cav-3 has been less studied in breast cancer, and the loss of its expression can form an antitumor microenvironment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…OBJECTIVE: To determine whether insulin reverses gestational diabetes mellitus (GDM)–reduced expression and activity of human equilibrative nucleoside transporters 1 (hENT1) in human umbilical vein endothelium cells (HUVECs). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Based on these results, it is proposed that both JA and ET promote the AAL toxin-induced cell death alone, and the JAI1 receptor-dependent JA pathway also acts upstream of ET biosynthesis in AAL toxin-triggered PCD.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…At the structural level, the crystal structure of rice Hb1 has been elucidated, and the structures of the other rice Hbs have been modeled. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our data revealed that CNTF acts as a potent inhibitor of cementogenesis, and it can trigger autophagy, in part by ERK1/2 and STAT3 commitment in the cementoblasts. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Animal studies showed that HMGB1 acted via RAGE to induce ILC2 accumulation in the lungs by promoting ILC2 proliferation and decreasing ILC2 death. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Two neurotransmitters play a central role in mediating the emetic response: serotonin acting on the 5HT3 receptor and the substance P targeting the NK1 receptor. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…MicroRNAs are important regulators of gene expression, acting primarily by binding to sequence-specific locations on already transcribed messenger RNAs (mRNA) and typically down-regulating their stability or translation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Bioinformatics analysis of 179 pancreatic cancer samples and 171 normal pancreatic tissue samples on the GEPIA platform identified 39 deferentially expressed genes in pancreatic cancer with 36 up-regulated genes (ACSL3, ACSL4, AGPAT2, BSCL2, CAV1, CAV2, CAVIN1, CES1, CIDEC, DGAT1, DGAT2, FAF2, G0S2, HILPDA, HSD17B11, ICE2, LDAH, LIPE, LPCAT1, LPCAT2, LPIN1, MGLL, NAPA, NCEH1, PCYT1A, PLIN2, PLIN3, RAB5A, RAB7A, RAB8A, RAB18, SNAP23, SQLE, VAPA, VCP, VMP1) and 3 down-regulated genes (FITM1, PLIN4, PLIN5). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…When we evaluated the adhesion profile of S. cerevisiae transformants, Pb14-3-3 acted as an adhesin in S. cerevisiae; however, Bmh1p did not show this function. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso