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  1. 10481
    “…House dust mites (HDMs) are globally significant triggers of allergy. Group 1 HDM allergens, exemplified by Der p 1, are cysteine proteases. …”
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    Targeting an Initiator Allergen Provides Durable and Expansive Protection against House Dust Mite Allergy
  2. 10482
    “…ATP-citrate (pro-S) lyase (ACL) is a key regulator in the acetyl-CoA pathway and plays an important role in citric acid metabolism. …”
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    Identification of CmACL genes in melon and analysis of their potential functions in fruit sugar and acid accumulation
  3. 10483
    “…As a result, this neurotransmitter may play a role in modulating counterregulatory responses. …”
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    Modulation of β-Adrenergic Receptors in the Ventromedial Hypothalamus Influences Counterregulatory Responses to Hypoglycemia
  4. 10484
    “…Once released, extracellular ATP acts on cells in a paracrine manner via purinergic receptors. …”
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    The P2X7 Receptor is an Important Regulator of Extracellular ATP Levels
  5. 10485
    “…In this study, we demonstrate that fucoidan reduces tumor size in LLC1-xenograft male C57BL/6 mice. Moreover, we found that LLC1-bearing mice continuously fed fucoidan showed greater antitumor activity than mice with discontinuous feeding. …”
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    Fucoidan inhibition of lung cancer in vivo and in vitro: role of the Smurf2-dependent ubiquitin proteasome pathway in TGFβ receptor degradation
  6. 10486
    “…This blockade was accompanied by inhibition of rapid phosphorylation of Akt, GSK3β, ERK and IκB as well as downregulation of c-Fos and NFATc1 at protein, suggesting that transcriptional suppression is a key mechanism for anti-osteoclastogenesis. …”
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    Massive elimination of multinucleated osteoclasts by eupatilin is due to dual inhibition of transcription and cytoskeletal rearrangement
  7. 10487
    “…We speculate that GAAC activation is widely conserved in trm7 mutants in eukaryotes, including metazoans, and might play a role in FTSJ1-mediated NSXLID.…”
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    Lack of 2'-O-methylation in the tRNA anticodon loop of two phylogenetically distant yeast species activates the general amino acid control pathway
  8. 10488
    “…Mechanistically, in vitro investigations indicated FGF2 acts in autocrine/paracrine fashions. Exogenous FGF2 supplementation inhibits both PGC-1α and PPARγ expression, leading to suppression of UCP1 expression in brown and beige adipocytes. …”
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    FGF2 disruption enhances thermogenesis in brown and beige fat to protect against adiposity and hepatic steatosis
  9. 10489
    “…BACKGROUND: The big challenge in any anti-tumor therapeutic approach is represented by the development of drugs selectively acting on the target with limited side effects, that exploit the unique characteristics of malignant cells. …”
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    Optimization of construct design and fermentation strategy for the production of bioactive ATF-SAP, a saporin based anti-tumoral uPAR-targeted chimera
  10. 10490
    por Schaschl, Helmut, Wallner, Bernard
    Publicado 2020
    “…At the same time, we found evidence for recent positive directional selection acting on several human testis-enriched genes (MORC1, SLC9B1, ROPN1L, DMRT1, PLCZ1, RNF17, FAM71D and WBP2NL) that play important roles in human spermatogenesis and fertilization. …”
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    Population-specific, recent positive directional selection suggests adaptation of human male reproductive genes to different environmental conditions
  11. 10491
    “…The overall genetic composition of each genotype, acting in trans, modulated the specific response to environment. …”
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    Unraveling the complexity of transcriptomic, metabolomic and quality environmental response of tomato fruit
  12. 10492
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    SSS-test: a novel test for detecting positive selection on RNA secondary structure
  13. 10493
    “…Meanwhile, knockdown of PtrERF9 decreased PtrACS1 expression, ACS activity and ACC content. However, overexpression of PtrERF9 in lemon, a cold‐sensitive species, caused negligible alterations of ethylene biosynthesis, which was attributed to perturbed interaction between PtrERF9, along with lemon homologue ClERF9, and the promoter of lemon ACS1 gene (ClACS1) due to mutation of the cis‐acting element. …”
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    ERF9 of Poncirus trifoliata (L.) Raf. undergoes feedback regulation by ethylene and modulates cold tolerance via regulating a glutathione S‐transferase U17 gene
  14. 10494
    “…Melatonin is a circadian rhythm regulator capable of controlling a variety of physiological processes in the body. It predominantly acts via the melatonin 1 (MT1) and MT2 receptors expressed in the CNS neurons and peripheral organs and tissues. …”
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    Melatonin inhibits muscular-mucosal stretch-sensitive bladder afferents via the MT2 receptors
  15. 10495
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    A TetR-family transcription factor regulates fatty acid metabolism in the archaeal model organism Sulfolobus acidocaldarius
  16. 10496
    “…Strains belonging to the phylogenetic group B2 are more frequently implicated in extraintestinal infections and include esterase B(2 )variants, whereas phylogenetic groups A, B1 and D contain less virulent strains and include esterase B(1 )variants. …”
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    aes, the gene encoding the esterase B in Escherichia coli, is a powerful phylogenetic marker of the species
  17. 10497
    “…TNF-α protein levels in the pre-EP (4.7 ± 1.2 pg/200 µg; P < 0.001) and post-EP (6.4 ± 1.8 pg/200 µg; P < 0.001) groups were 2-3 times lower than the control group (14.4 ± 1.2 pg/200 µg). …”
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    Effects of Ethyl Pyruvate on Allodynia, TNF-α Expression, and Apoptosis in the Dorsal Root Ganglion after Spinal Nerve Ligation Injury
  18. 10498
    “…These results suggest that PG feeding has an anti‐obesity effect and that the regulation of SREBP‐1c and leptin secretion play a role in this effect.…”
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    Effects of salmon cartilage proteoglycan on obesity in mice fed with a high‐fat diet
  19. 10499
    “…Superoxide dismutases (SODs) play an important role in protecting plants against ROS toxicity induced by biotic and abiotic stress. …”
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    The Superoxide Dismutase Gene Family in Nicotiana tabacum: Genome-Wide Identification, Characterization, Expression Profiling and Functional Analysis in Response to Heavy Metal Stress
  20. 10500
    “…However, the mechanism of radiation resistance in H1299 cells is that GATA3 acts as a transcription inhibitor. The decrease of GATA3 will promote the increase of NRP1 transcription, in which H3K4me3 does not play a leading role. …”
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    GATA3 Exerts Distinct Transcriptional Functions to Regulate Radiation Resistance in A549 and H1299 Cells
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