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  1. 10521
    “…Horizontal drilling and hydraulic fracturing extraction procedures have become increasingly present in Pennsylvania where the Marcellus Shale play is largely located. The potential for long-term environmental impacts to nearby headwater stream ecosystems and aquatic bacterial assemblages is still incompletely understood. …”
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    Response of Aquatic Bacterial Communities to Hydraulic Fracturing in Northwestern Pennsylvania: A Five-Year Study
  2. 10522
    “…As the distribution of the mannose-specific PTS (PTS(Man)) is limited to animal-associated bacteria, it has been suggested to play an important role in host-bacteria interactions. …”
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    A mannose-sensing AraC-type transcriptional activator regulates cell–cell aggregation of Vibrio cholerae
  3. 10523
    “…In human purified naive T cells, PGE2 acts via prostaglandin receptor EP2- and EP4-mediated signaling and cyclic AMP pathways to up-regulate IL-23 and IL-1 receptor expression. …”
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    Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling
  4. 10524
    “…OBJECTIVE: Adenosine deaminase acts on adenosine and deoxyadenosine metabolism and modulates the immune response. …”
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    The ADA*2 allele of the adenosine deaminase gene (20q13.11) and recurrent spontaneous abortions: an age-dependent association
  5. 10525
    “…Toll-like receptors (TLRs) play a critical role in shaping innate and adaptive immune responses. …”
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    PAFR activation of NF-κB p65 or p105 precursor dictates pro- and anti-inflammatory responses during TLR activation in murine macrophages
  6. 10526
    “…Recently, the crustacean female sex hormone (CFSH), which is considered a female-specific hormone, has been shown to play a crucial role in female phenotypes in crustaceans. …”
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    Crustacean Female Sex Hormone From the Mud Crab Scylla paramamosain Is Highly Expressed in Prepubertal Males and Inhibits the Development of Androgenic Gland
  7. 10527
    “…Interestingly, at multiple steps during Salmonella evolution, the type I fimbriae and various virulence genes encoded within SPIs 1, 2, 4, 5, and 11 have been transcriptionally integrated under the ancestral DksA regulon. …”
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    The ancestral stringent response potentiator, DksA has been adapted throughout Salmonella evolution to orchestrate the expression of metabolic, motility, and virulence pathways
  8. 10528
    “…MADS-box is an ancient and huge gene family that plays a key role in plant floral organ differentiation. …”
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    Genome-wide analysis of MADS-box gene family in kiwifruit (Actinidia chinensis var. chinensis) and their potential role in floral sex differentiation
  9. 10529
    “…CONCLUSIONS: We confirmed through experimental validation our prediction of WelI acting upstream of WelE in the biosynthesis of exopolysaccharides. …”
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    A network-based approach to identify substrate classes of bacterial glycosyltransferases
  10. 10530
    “…Bone morphogenetic proteins (BMPs) belong to the transforming growth factor β (TGFβ) superfamily of secreted molecules. BMPs play essential roles in multiple developmental and homeostatic processes in metazoans. …”
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    Promotion of Bone Morphogenetic Protein Signaling by Tetraspanins and Glycosphingolipids
  11. 10531
    “…Our analysis revealed stronger positive, diversifying selection acting in TLR5 and the three-domain TLRs (TLR10 [TLR1A], TLR1 [TLR1B], TLR2A, TLR2B, TLR4) that face the extracellular space and bind complex ligands than in single-domain TLR15 and endosomal TLRs (TLR3, TLR7, TLR21). …”
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    Toll-Like Receptor Evolution in Birds: Gene Duplication, Pseudogenization, and Diversifying Selection
  12. 10532
    “…Cytohubber analysis showed that GNG11, FPR2, P4HB, PIK3R1, CDC20, ADCY4, TIMP1, IL6, CXC chemokine ligand (CXCL)12, and GAS6 acted as the hub genes during lung adenocarcinoma. …”
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    Integration of gene profile to explore the hub genes of lung adenocarcinoma: A quasi-experimental study
  13. 10533
    “…Gene Ontology analysis showed that these proteins play diverse functions in cell growth, cell wall biosynthesis, hormone signaling, stress response, membrane transport, and nutrient uptake. …”
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    The EXO70 inhibitor Endosidin2 alters plasma membrane protein composition in Arabidopsis roots
  14. 10534
    “…A recent study by the Autism Genome Project (AGP) used 1M single-nucleotide polymorphism arrays to show that rare genic copy number variants (CNVs), possibly acting in tandem, play a significant role in the genetic aetiology of this condition. …”
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    A family with autism and rare copy number variants disrupting the Duchenne/Becker muscular dystrophy gene DMD and TRPM3
  15. 10535
    “…A wheat PSY3 promoter region was also investigated for the presence of cis-acting elements involved in the response to abscisic acid (ABA), since carotenoids also play an important role as precursors of signalling molecules devoted to plant development and biotic/abiotic stress responses. …”
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    Deciphering the genomic structure, function and evolution of carotenogenesis related phytoene synthases in grasses
  16. 10536
    “…Idiopathic membranous nephropathy (IMN) is known to be associated with antibodies acting on the M-type phospholipase A2 receptor (PLA2R) of the podocyte. …”
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    HLA-DR, and not PLA2R, is expressed on the podocytes in kidney allografts in de novo membranous nephropathy
  17. 10537
    “…Much of the data resulting from different laboratories support the role of poly(ADP-ribose) polymerase (PARP) 1 and PARP14 activation in asthma. Indeed, PARP enzymes play key roles in the regulation and progression of the inflammatory asthma process because they affect the expression of genes and chemokines involved in the immune response. …”
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    Asthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach
  18. 10538
    “…Our ubiquitination assay demonstrated that the Ring finger domain of hMEX‐3C acts as a ubiquitin E3 ligase in vitro, cooperating with specific E2 to mediate ubiquitination. …”
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    Structural and functional characterization of hMEX‐3C Ring finger domain as an E3 ubiquitin ligase
  19. 10539
    “…More studies are needed to elucidate the mechanism how NF2 acts in thyroid cancer with BRAF mutation.…”
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    Expression of NF2 Modulates the Progression of BRAF(V600E) Mutated Thyroid Cancer Cells
  20. 10540
    “…Platelet-type von Willebrand disease is an inherited platelet disorder characterized by thrombocytopenia with large platelets caused by gain-of-function variants in GP1BA leading to enhanced GPIbα-von Willebrand factor (vWF) interaction. …”
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    Mechanisms of thrombocytopenia in platelet-type von Willebrand disease
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