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  1. 10821
    “…In this study, we found that itaconate acts as an anti-inflammatory factor in the liver. …”
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    Itaconate attenuates autoimmune hepatitis via PI3K/AKT/mTOR pathway-mediated inhibition of dendritic cell maturation and autophagy
  2. 10822
    “…CONCLUSION: The present study shows that oxidative stress is an important mechanism contributing to CEES toxicity in LPS stimulated macrophages and supports the notion that antioxidants could play a therapeutic role in preventing mustard gas toxicity. …”
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    The influence of N-acetyl-L-cysteine on oxidative stress and nitric oxide synthesis in stimulated macrophages treated with a mustard gas analogue
  3. 10823
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    Epidermal growth factor induces platelet-activating factor production through receptors transactivation and cytosolic phospholipase A(2) in ovarian cancer cells
  4. 10824
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    The autophagy interaction network of the aging model Podospora anserina
  5. 10825
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    A mathematical model for histamine synthesis, release, and control in varicosities
  6. 10826
    “…Results: We observe a systematic approach of post-millennial health policy decisions on prevention and on defined health targets in Germany, exemplified by (1) the fostering of the preparedness against pandemic infectious diseases, (2) the development and implementation of the first cancer vaccination, (3) major legal provisions on non-smokers protection in the public domain, (4) acts to strengthen long term care (LTC) as well as (5) the new German E-Health legislation. …”
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    Human Dignity as Leading Principle in Public Health Ethics: A Multi-Case Analysis of 21st Century German Health Policy Decisions
  7. 10827
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    Tension band plating of an anterior tibial stress fracture nonunion in an elite athlete, initially treated with intramedullary nailing: a case report
  8. 10828
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    “It’s a matter of building bridges…” – feasibility of a carer involvement intervention for inpatients with severe mental illness
  9. 10829
    “…BACKGROUND: Macrophage play a crucial role in regulating tumor progression. …”
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    Construction and analysis of macrophage infiltration related circRNA-miRNA-mRNA regulatory networks in hepatocellular carcinoma
  10. 10830
    “…Methanogens and methanotrophs both play a key role in mediating CH(4) fluxes, therefore we hypothesized that the CaSSP-mediated reduction in CH(4) emissions was attributed to the shift of methanogens and methanotrophs, which was regulated by physicochemical parameter changes. …”
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    Decreased Methane Emissions Associated with Methanogenic and Methanotrophic Communities in a Pig Manure Windrow Composting System under Calcium Superphosphate Amendment
  11. 10831
    “…The potential function of hypomethylated gene body as a cis-acting element was evaluated by ChIP analysis using anti-H3K4me1 and anti-H3K27ac antibodies and eRNA expression analysis.…”
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    SAT-199 A Hypomethylated GATA6 Gene Body May Function as an Active Enhancer in Endometriotic Cells
  12. 10832
    “…In RAAS, ACE2 degrades angiotensin II, which is a multifunctional CVD-promoting peptide hormone and converts it to a heptapeptide angiotensin-(1–7) acting as the angiotensin II antagonist. As protein multifunctionality is commonly associated with the presence of flexible or disordered regions, we analyze here the intrinsic disorder predisposition of major players related to the SARS-CoV-2 – RAAS axis. …”
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    Intrinsic disorder perspective of an interplay between the renin-angiotensin-aldosterone system and SARS-CoV-2
  13. 10833
    “…BACKGROUND: VGF (nonacryonimic) and phosphatidylinositol 3-kinase (PI3K)/AKT (also known as protein kinase B, PKB)/mammalian target of rapamycin (mTOR) signaling play pivotal roles in depression. However, whether phosphatidylinositol 3-kinase/AKT/mTOR signaling-mediated VGF participates in rapid-acting antidepressant-like actions of GLYX-13 is unclear. …”
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    PI3K/AKT/mTOR Signaling-Mediated Neuropeptide VGF in the Hippocampus of Mice Is Involved in the Rapid Onset Antidepressant-Like Effects of GLYX-13
  14. 10834
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    TIPE3 hypermethylation correlates with worse prognosis and promotes tumor progression in nasopharyngeal carcinoma
  15. 10835
    “…Moreover, they can form complexes (e.g., with Signal transducers and activators of transcription, STATs) and collaborate with other co-acting transcription factors such as Nuclear factor-κB (NF-κB) and PU.1. …”
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    Direct Inhibition of IRF-Dependent Transcriptional Regulatory Mechanisms Associated With Disease
  16. 10836
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    Genome-wide identification and characterization of long non-coding RNAs involved in fruit ripening and the climacteric in Cucumis melo
  17. 10837
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    Genome-wide identification and analysis of B-BOX gene family in grapevine reveal its potential functions in berry development
  18. 10838
    “…The AcJAZ genes have 3–10 exons, and the putative AcJAZ proteins have between two and eight conserved regions, including the TIFY motif and Jas domain. The cis-acting element analysis revealed that the putative promoter regions of AcJAZs contain between three and eight abiotic stress-responsive cis-acting elements. …”
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    Investigation of the JASMONATE ZIM-DOMAIN Gene Family Reveals the Canonical JA-Signaling Pathway in Pineapple
  19. 10839
    “…SIMPLE SUMMARY: Metformin is a drug commonly used to treat diabetes but it may play a role in cancer treatment. It is not known exactly how metformin acts on cancer cells and cells in the tumor microenvironment (TME). …”
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    Shifting the Soil: Metformin Treatment Decreases the Protumorigenic Tumor Microenvironment in Epithelial Ovarian Cancer
  20. 10840
    “…Overall, satisfaction with oral anticoagulation was high (ACTS Burdens scale 49.69±9.45; ACTS Benefits scale 11.35±2.61). …”
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    Satisfaction with oral anticoagulants in patients with atrial fibrillation
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