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  1. 10881
    por Sato, Atsushi, Menez, Andre
    Publicado 2018
    “…The molecular mechanism suggested by this experiment was assessed with a well-defined 3D structure of erabutoxin b because one of the turns that played a critical role in folding was shared with erabutoxin b.…”
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    External release of entropy by synchronized movements of local secondary structures drives folding of a small, disulfide-bonded protein
  2. 10882
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    Online Artículo Texto
    Patients’ experiences of internet-based Acceptance and commitment therapy for chronic pain: a qualitative study
  3. 10883
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    Reproductive development and genetic structure of the mycoheterotrophic orchid Pogoniopsis schenckii Cogn.
  4. 10884
    “…CONCLUSION: These results suggest that anandamide, an endogenous cannabinoid ligand, may modulate cough sensitivity and that anandamide transporters play an important role in this modulation. Furthermore, these findings indicate that inhibition of the uptake of anandamide produced a potent antitussive effect and suggests that the anandamide transporter may be a potential target for peripherally acting antitussive drugs.…”
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    Effect of N-arachidonoyl-(2-methyl-4-hydroxyphenyl) amine (VDM11), an anandamide transporter inhibitor, on capsaicin-induced cough in mice
  5. 10885
    “…Expression analysis of stress-responsive genes in GbRLK Arabidopsis revealed that there was increased expression of genes involved in the ABA-dependent signaling pathway (AtRD20, AtRD22 and AtRD26) and antioxidant genes (AtCAT1, AtCCS, AtCSD2 and AtCSD1) but not ion transporter genes (AtNHX1, AtSOS1). …”
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    A receptor-like kinase gene (GbRLK) from Gossypium barbadense enhances salinity and drought-stress tolerance in Arabidopsis
  6. 10886
    “…It can not only mediate glucose-dependent insulin secretion and lower blood glucose by activating VPAC2 receptor, but also raise blood glucose by promoting glucagon production by VPAC1 receptor activation. Therefore, its therapeutic application is restricted by the exceedingly short-acting half-life and the stimulatory function for glycogenolysis. …”
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    A novel selective VPAC2 agonist peptide-conjugated chitosan modified selenium nanoparticles with enhanced anti-type 2 diabetes synergy effects
  7. 10887
    por Wang, Sidney H., Elgin, Sarah C. R.
    Publicado 2019
    “…Further, the pattern of variegation becomes almost identical within each inbred line; significant pigment enrichment in the same quadrant of the eye was found for both A1 and D1 lines despite different degrees of expression. …”
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    The impact of genetic background and cell lineage on the level and pattern of gene expression in position effect variegation
  8. 10888
    “…Cortical loops through basal ganglia (BG) structures are known to play critical roles in the typical functioning of these actions. …”
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    Increased Dopamine Type 2 Gene Expression in the Dorsal Striatum in Individuals With Autism Spectrum Disorder Suggests Alterations in Indirect Pathway Signaling and Circuitry
  9. 10889
    “…INTRODUCTION: IL-37 is a cytokine of IL-1 family that plays an important role in innate immunity and inflammation, and has been studied as a tumor suppressor in many cancers. …”
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    IL-37 induces anti-tumor immunity by indirectly promoting dendritic cell recruitment and activation in hepatocellular carcinoma
  10. 10890
    “…BACKGROUND AND PURPOSE: Lipid mediators (LM) play crucial roles in the complex inflammation process with respect to initiation, maintenance, and resolution. …”
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    Shifting the Biosynthesis of Leukotrienes Toward Specialized Pro-Resolving Mediators by the 5-Lipoxygenase-Activating Protein (FLAP) Antagonist BRP-201
  11. 10891
    “…We present the cases of two patients with EIB, one with asthma, and one without asthma, who were evaluated at our primary care practice. …”
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    Exercise-induced bronchospasm: implications for patients with or without asthma in primary care practice
  12. 10892
    “…BACKGROUND: Thymosin β10 (TMSB10) has been reported to play a protumorigenic role in a majority of solid cancers. …”
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    Thymosin β10 promotes tumor-associated macrophages M2 conversion and proliferation via the PI3K/Akt pathway in lung adenocarcinoma
  13. 10893
    “…Taken together, our data suggest that PHDs of KMT2A-D guide the full-length proteins to active promoters and enhancers, and thus play a role in positive transcriptional memory. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00018-022-04651-1.…”
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    Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers
  14. 10894
    “…A total of 33 E. coli O157:H7 strains were exposed to seven different stress conditions acting as potential selective pressures affecting the transmission of E. coli O157:H7 to humans through the food chain. …”
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    Diversity of Survival Patterns among Escherichia coli O157:H7 Genotypes Subjected to Food-Related Stress Conditions
  15. 10895
    “…In this study we report that the outer membrane component lipopolysaccharide (LPS) plays a crucial role for the antimicrobial susceptibility of E. coli BW25113 against the cationic AMPs Cap18, Cap11, Cap11-1-18m(2), melittin, indolicidin, cecropin P1, cecropin B, and the polypeptide antibiotic colistin, whereas the outer membrane protease OmpT and the lipoprotein Lpp only play a minor role for the susceptibility against cationic AMPs. …”
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    The Role of Outer Membrane Proteins and Lipopolysaccharides for the Sensitivity of Escherichia coli to Antimicrobial Peptides
  16. 10896
    “…Canonical RNA editing (i.e., A-to-I and C-to-U editing) mediated by the adenosine deaminases acting on RNA (ADAR) family and apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) family during the transcriptional process is considered common and essential for the development of an individual. …”
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    Genome-wide profiling of RNA editing sites in sheep
  17. 10897
    “…Apart from its transporter function, NTCP acts as the high-affinity liver-specific receptor for the hepatitis B virus (HBV), which attaches via its preS1-peptide domain of the large surface protein to NTCP, subsequently leading to endocytosis of the virus/NTCP-receptor complex. …”
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    Tyrosine 146 of the Human Na(+)/Taurocholate Cotransporting Polypeptide (NTCP) Is Essential for Its Hepatitis B Virus (HBV) Receptor Function and HBV Entry into Hepatocytes
  18. 10898
    “…BACKGROUND: Heat stress factors (Hsfs) play vital roles in signal transduction pathways operating in responses to environmental stresses. …”
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    Genome-wide characterization of tea plant (Camellia sinensis) Hsf transcription factor family and role of CsHsfA2 in heat tolerance
  19. 10899
    “…It is known that COX-2/PGE(2) play key roles in the pathogenesis of airway inflammation. …”
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    Evidence for the critical role of the PI3K signaling pathway in particulate matter-induced dysregulation of the inflammatory mediators COX-2/PGE(2) and the associated epithelial barrier protein Filaggrin in the bronchial epithelium
  20. 10900
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    Circulating microRNAs as predictors of response to sofosbuvir + daclatasvir + ribavirin in in HCV genotype-4 Egyptian patients
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