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  1. 10921
    “…Findings indicate that: (1) Acamprosate and gabapentin may selectively modulate limbic regions and the anterior cingulate cortex; (2) Naltrexone and disulfiram effects may involve prefrontal, premotor, and cerebellar regions; (3) Pharmacotherapies acting on glutamate and GABA neurotransmission involve primarily areas underpinning reward and negative affective states, and; (4) Pharmacotherapies acting on opioid and dopamine systems may affect areas responsible for the cognitive and motor factors of AUD. …”
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  2. 10922
    “…BACKGROUND: Long non-coding RNAs (lncRNAs), a class of endogenous non-coding RNAs, play an important role in the development and metastasis of non-small cell lung cancer (NSCLC). …”
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  3. 10923
    “…Triticum aestivum xylanase inhibitor (TaXI) gene plays an important role in plant defense. Recently, TaXI–III inhibitor has been shown to play a dual role in wheat resistance to Fusarium graminearum infection. …”
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  4. 10924
  5. 10925
    “…BACKGROUND: Leptin (LEP) acts as a proinflammatory cytokine and may play an important role in the pathophysiology of cystic fibrosis (CF). …”
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  6. 10926
    “…In contrast, major histocompatibility complex (MHC) class I chain-related molecule A (MICA), which acts as a ligand for NKG2D in natural killer (NK) cells and CD8+ T cells, is related to a higher survival rate in patients with oral squamous cell carcinoma (OSCC). …”
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  7. 10927
    “…INTRODUCTION: In the last years there has been increasing evidence that inflammation and autoimmunity may play a role in the pathogenesis of schizophrenia. …”
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  8. 10928
    “…In plants, they are not only involved in growth and development, defense and stress responses and regulation of physiological processes but also play a pivotal role in regulating secondary metabolism. …”
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  9. 10929
  10. 10930
    “…BACKGROUND: As a large family of regulatory proteins, WRKY transcription factors play essential roles in the processes of adaptation to diverse environmental stresses and plant growth and development. …”
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  11. 10931
  12. 10932
    “…Discs from 11 healthy dogs acted as controls (C). Samples were analyzed for IL-1, IL-6, IL-8, and TNF-α expression (qPCR/ELISA) as well as cell infiltration and activation of the MAP kinase pathways (immunohistochemistry). …”
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  13. 10933
    “…It could support patients to take responsibility for self-managing their health and treatment regimens, as well as helping patients to play a more active role when care transfers across boundaries of responsibility.…”
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  14. 10934
    “…Thrombin, plasmin, activated complement factors and matrix metalloproteinase-1 (MMP-1), furthermore, activate intracellular transduction through complement or protease-activated receptors. …”
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  15. 10935
  16. 10936
    “…Increasing the number of EPC and alleviating EPC dysfunction induced by pro-inflammatory mediators play important roles in suppressing ALI development. …”
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  17. 10937
  18. 10938
    “…At the cellular level, vitamin B12 acts as a cofactor for enzymes that play a critical role in DNA synthesis and neuroprotection. …”
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  19. 10939
    “…During viral infection, the dynamic virus-host relationship is constantly in play. Many cellular proteins, such as RNA-binding proteins (RBPs), have been shown to mediate antiviral responses during viral infection. …”
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  20. 10940
    “…Rapid scale-up of vaccination efforts could play an important role in mitigating these and future waves of the disease. …”
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