“…CONCLUSIONS: In conclusion, we constructed two circRNA-miRNA-mRNA regulatory networks and identified 3 prognostic and screening biomarkers, COL12A1, COL5A2, and THBS1. The ceRNA network and these genes could play important roles in GC development, diagnosis and prognosis. …”
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“…Furthermore, miR-148a directly and negatively influenced the expression of signalling molecules related to the MAPK signalling pathway, including MAPK11, TGF-β2, and Jun, and regulated antiviral responses through interferon-stimulated genes and MHC class I and class II genes by targeting IFN-γ. Downstream of the MAPK signalling pathway, several proinflammatory cytokines such as IL-1β, IFN-γ, IL-6, TNF-α, IFN-β, and interferon-stimulated genes were downregulated by the overexpression of gga-miR-148a. …”
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“…In the case of plant virus infection, it appears that m6A plays a dual role. On the one hand, m6A acts as a plant immune response induced by virus infection, inhibiting viral replication or translation through methylation of viral genome RNAs. …”
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“…The total mean score of emotional labour was 3.17 ± 0.67, of which the surface acting (SA) score was 2.28 ± 0.90, and the deep acting (DA) score was 3.91 ± 0.93. …”
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“…To detemine if the truncated isoform of the receptor could serve as a potential source of antigen and modulate GD we used double transfected cells expressing both GFP tagged TSHR-v1.3 and full-length TSHR. We then induced cell stress and apoptosis using a TSHR-mAb directed to the cleavage region (Tab16) and observed a dose dependent increase in mitochondrial cell stress and increased apoptosis (viability <46%) compared to control isotype specific antibody treated or untreated cells (74/71% viability).The culture supernatant contained released V1.3 tagged GFP protein suggesting that release of a new TSHR receptor antigen by this mechanism could play an important role in modulation of the disease process. …”
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“…A total of 286 known miRNAs, 332 known miRNA precursor sequences, and 438 new miRNAs were predicted. A total of 1,048,575 mRNA–miRNA interaction sites were obtained, and 21,252 and 21,241 target genes were respectively predicted in known and new miRNAs. qPCR revealed that HO-1, IL-10R1, apoA-I, and HBP2 were significantly differentially expressed and might play important roles in the toxicity and liver detoxification of MC-LR in fish. …”
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“…CONCLUSIONS: In especial, CASP4 can promote tumor progression by promoting the synthesis and accumulation of fatty acids, while NLRP1 acts on RAS/ERK signaling pathway. Both of genes play an important role in the diagnosis and treatment of PDAC, which may also affect the inhibitors of MAPK/ERK efficiency. …”
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“…We suggest that similar modified lipids could have played a key role in early life, and that primitive lipid membranes and encapsulated catalysts, such as ribozymes, may have acted in conjunction with each other, enabling otherwise-impossible chemical transformations within primordial cells.…”
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“…BACKGROUND: MicroRNAs (miRNAs) are a family of short non-coding RNA molecules and play important roles in various biological processes. …”
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“…ERF transcription factors play an important role in various abiotic stresses in plants. …”
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“…Recent studies have demonstrated that chronic inflammation-induced lymphangiogenesis plays a crucial role in the progression of various renal diseases, including diabetic nephropathy. …”
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“…Overexpression of the activin A antagonist follistatin reduced tissue damage and collagen I(+) TM accumulation in WT EAO testes, while treating macrophages with activin A in vitro increased the expression of Ccr2, Fn1, Cxcr4, and Mmp2 and enhanced migration along a CCL2 gradient; these effects were abolished by follistatin. …”
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“…Claudin-6 (CLDN6), a tight junction protein, acts as a tumor suppressor gene in breast cancer. …”
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“…[Image: see text] The presence of alkaline phosphatases has been observed in several species and has been known to play a crucial role in various biological functions. …”
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“…In the promoter regions of BpJMJ genes, cis-acting elements associated with hormone and abiotic stress responses were overrepresented. …”
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“…Similarly, little is known about moral distress among field epidemiologists, i.e., situations in which they are constrained from acting on what they know to be morally right. …”
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“…Chromatin immunoprecipitation indicated that mithramycin attenuates Sp1 binding to pro-apoptotic gene promoters without altering p53 binding suggesting it acts by removing cofactors required for p53 transactivation. …”
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“…OSCA (hyperosmolality-gated calcium-permeable channel) gene family members play an important role in the modulation of hypertonic stress, such as drought and salinity. …”
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“…BACKGROUND: Abscisic acid (ABA) and proline play important roles in rice acclimation to different stress conditions. …”
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“…Extracellular vesicles (EVs) play an important role in human and bovine milk composition. …”
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