“…Circular RNA (CircRNA) and microRNA (miRNA), acting as competing endogenous RNAs (ceRNAs), have been found to play vital roles in carcinogenesis. …”
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“…Microbiota plays essential roles in the health, physiology, and in adaptation of marine multi-cellular organisms to their environment. …”
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“…Strikingly, the unique sugar moiety at N370 of bat SC2r-CoVs acts like a “bolt” and crosses over two neighboring subunits, facilitating the S proteins in the locked conformation and underpinning the architecture stability. …”
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“…A major inducer of T cell cAMP levels is PG E(2) (PGE(2)) acting through EP2 and EP4 prostanoid receptors. PGE(2) plays a crucial role in the normal physiological control of immune homeostasis as well as in inflammation and cancer immune evasion. …”
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“…BACKGROUND: Despite the Government acting quickly to reassure parents about MMR safety following the publication of the 1998 paper by Wakefield and colleagues, MMR uptake declined. …”
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“…Gene duplication is a major mechanism playing a role in the evolution of phenotypic complexity and in the generation of novel traits. …”
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“…We found relatively stable levels of stress and recovery across the season; total recovery levels were higher than stress at all four measured timepoints (p<0.05); All athletes had at least one injury, with a total of 14 injuries; No significant correlations were found between the quantitative scores of resilience, stress and recovery; Training and the sport’s scoring system were the most relevant perceived stressors; athletes presented meta-cognition and a non-positive evaluation (neutral) of stressors; Social support was considered the main psychological factor for the resilience process; such process resulted in improved control and interpretation of emotions; Our hypothesized model proposes that, in the relationship between stress and injuries, resilience acts by optimizing the injury recovery process. …”
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“…Artemis (SNM1C/DCLRE1C) is an endonuclease that plays a key role in development of B- and T-lymphocytes and in dsDNA break repair by non-homologous end-joining (NHEJ). …”
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“…Here we present data showing that artemisinin directly acts on mitochondria and it inhibits malaria in a similar way as yeast. …”
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“…Glucokinase (GK) is a glycolytic enzyme that plays an important role in regulating blood glucose level, thus acting as a potentially attractive target for drug discovery in the treatment of diabetes of the young type 2 and persistent hyperinsulinemic hypoglycemia of infancy. …”
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“…Fibronectin (Fn) is an essential component of the ECM, and plays an important role in fibrosis. One such fibrotic pathology is that of proliferative vitreoretinopathy (PVR), a sight-threatening complication which develops as a consequence of failure of surgical repair of retinal detachment. …”
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“…We then compared the expression of cytokine and chemokine genes known to be induced during inflammation. Interleukin (Il)-1β, Il-6, and monocyte chemotactic protein 1 were all down regulated in the fractures derived from Darc-KO mice at one day post-fracture, consistent with an altered inflammatory response. …”
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“…LYP is a known negative regulator of signaling through the T cell receptor (TCR), and murine Ptpn22 plays a role in thymic selection. However, the mechanism of action of the R620W variant in autoimmunity remains unclear. …”
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“…Boron further stimulated the secretion of TNF-α, IL-6, IL-1β, NO and the expression of iNOS by the LPS-primed macrophages. …”
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“…The Drosophila homolog of the protooncogene transcription factor Myc plays a major role in promoting this endopolyploid (EP) growth. …”
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“…In addition, TMS over the right DLPFC had no specific effect on the colored distractor compared to the white one. Considered collectively, these findings indicate that the DLPFC plays a crucial role in visuospatial distractor suppression and acts upon stimuli presentation. …”
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“…[Image: see text] Cytochrome c (Cyt c), one of the most significant proteins acting as an electron transporter, plays an important role during the transferring process of the energy in cells. …”
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“…As one of the key enzymes in the pentose phosphate pathway (PPP), glucose-6-phosphate dehydrogenase (G6PDH) provides NADPH and plays an important role in plant development and stress responses. …”
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“…Finally, we explored its anti-HSV-1 mechanism, and the results showed that Fr.8.3 exerted an anti-HSV-1 effect by acting directly on the virus itself. …”
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“…BACKGROUND: Appropriate infant feeding and movement behaviour (i.e. physical activity, sedentary behaviour, sleep) play an important role in children’s healthy development during the first two years of life. …”
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