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  1. 11361
    “…Although it is still unknown why Mdm2 and Mdmx both are required for p53 degradation, a model has been proposed whereby these two proteins function independent of one another; Mdm2 acts as an E3 ubiquitin ligase that catalyzes the ubiquitination of p53 for degradation, whereas Mdmx inhibits p53 by binding to and masking the transcriptional activation domain of p53, without causing its degradation. …”
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    Regulation of p53: a collaboration between Mdm2 and MdmX
  2. 11362
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    “An Eye for an Eye”? Neural Correlates of Retribution and Forgiveness
  3. 11363
    “…Moreover, Hfq positively affected the transcript abundance of genes encoding type I toxin-antitoxin systems. Taken the moderate effect on sRNA levels and mRNAs together, it seems rather unlikely that Hfq plays a central role in RNA transactions in Bacillus subtilis.…”
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    Impact of Hfq on the Bacillus subtilis Transcriptome
  4. 11364
    por Ohba, Shinsuke
    Publicado 2016
    “…Endochondral ossification is one of the notable developmental events in which Hh signaling acts as a master regulator. …”
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    Hedgehog Signaling in Endochondral Ossification
  5. 11365
    por Grbić, E, Peterlin, A, Kunej, T, Petrovič, D
    Publicado 2018
    “…Several risk factors are included, with diabetes being one of the most important for the onset and development of atherosclerosis. …”
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    PPAR𝛾 Gene and Atherosclerosis: Genetic Polymorphisms, Epigenetics and Therapeutic Implications
  6. 11366
    por Zhang, Chungang, Xie, Yongjun, Dai, Legen
    Publicado 2020
    “…It consists of a boat-radiator and a dual C-shape co-radiative ground (DCCRG). One half of the DCCRG plays a role of the ground of a co-planar waveguide fed to the proposed boat-radiator antenna (BRA), while the other half works as a multiple order L-resonant circuit to broaden the lower operating band. …”
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    UWB Low-Profile Boat-Radiator Antenna (BRA) with Dual C-Shape Co-Radiative Ground for Multi-Standard Communication Networks
  7. 11367
    por Kanova, Marcela, Kohout, Pavel
    Publicado 2021
    “…Serotonin (5-hydroxytryptamine, 5-HT) plays two important roles in humans—one central and the other peripheral—depending on the location of the 5-HT pools of on either side of the blood-brain barrier. …”
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    Serotonin—Its Synthesis and Roles in the Healthy and the Critically Ill
  8. 11368
    “…In our modern society, however, the interaction of activated intravascular allosteric proteins with one another and with blood cells entails vulnerabilities posing a biological paradox: intravascular proteins that locally operate as tissue repair enhancers can nevertheless generate pathogenic processes by acting systemically. …”
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    Evolutionary Insight into Immunothrombosis as a Healing Mechanism
  9. 11369
    “…In vertebrates, one of the first recognizable sex differences in embryos is the onset of meiosis, known to be regulated by retinoic acid (RA) in mammals. …”
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    Retinoic acid and meiosis induction in adult versus embryonic gonads of medaka
  10. 11370
    “…Antibacterial activity assays showed that holin had an intracellular penetrating activity against S. enteritidis 35; both endolysins acted on the cell envelope of S. enteritidis 35 and showed a natural extracellular antibacterial activity, leading to a ~ 1 log titer decrease in 30 min. …”
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    Endolysins of bacteriophage vB_Sal-S-S10 can naturally lyse Salmonella enteritidis
  11. 11371
    por Taylor-Brown, Emilie, Hurd, Hilary
    Publicado 2013
    “…We examine the role that addiction modules may have played in the original eukaryote cell and the part played by mitochondria in the execution of present day cells, looking for examples from Leishmania spp. …”
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    The first suicides: a legacy inherited by parasitic protozoans from prokaryote ancestors
  12. 11372
    “…The retromer complex is a protein complex that plays a central role in endosomal trafficking. Retromer dysfunction has been linked to a growing number of neurological disorders. …”
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    Role of the Retromer Complex in Neurodegenerative Diseases
  13. 11373
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    Subcellular localization of glypican-5 is associated with dynamic motility of the human mesenchymal stem cell line U3DT
  14. 11374
    por Torner, Luz
    Publicado 2016
    “…Prolactin (PRL) is one of the most versatile hormones known. It is considered an adaptive hormone due to the key roles it plays in the modulation of the stress response and during pregnancy and lactation. …”
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    Actions of Prolactin in the Brain: From Physiological Adaptations to Stress and Neurogenesis to Psychopathology
  15. 11375
    “…Our results reveal five genes (Alkbh5, Dmrtb1, Pld6, Nlrp3, Sp4) that each have played unique and complex roles in tetrapod testis size diversity. …”
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    Genes underlying the evolution of tetrapod testes size
  16. 11376
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    Match-related physical performance in professional soccer: Position or player specific?
  17. 11377
    por Lu, Han, Gao, Mingjun
    Publicado 2023
    “…In a recent article, Ke et al. discovered a distinct pathogen effector, which acted as an immune elicitor in plants but also played dual roles in compromising plant immune activation and increasing nutrient acquisition from the host plants for pathogen propagation.…”
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    Dual functions of a novel effector in the plant and pathogen arms race
  18. 11378
    “…Most recently, accumulating evidence has demonstrated that the autophagy–lysosomal pathway plays a crucial role in the pathophysiological process after SAH. …”
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    The autophagy–lysosomal system in subarachnoid haemorrhage
  19. 11379
    “…We recently described two opposing states of transcriptional competency. One is termed ‘competent’ whereby a gene is capable of responding to trans-acting transcription factors of the cell, such that it is active if appropriate transcriptional activators are present, though it can also be silent if activators are absent or repressors are present. …”
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    Chromatin analysis of occluded genes
  20. 11380
    por Majumdar, Ritankar, Dighe, Rajan R.
    Publicado 2012
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    The Hinge Region of Human Thyroid-Stimulating Hormone (TSH) Receptor Operates as a Tunable Switch between Hormone Binding and Receptor Activation
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