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  1. 1141
    “…BACKGROUND: The neural cell adhesion molecule L1 plays a crucial role in development and plasticity of the nervous system. …”
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    Nuclear factor I-A represses expression of the cell adhesion molecule L1
  2. 1142
    por Zhao, Jiangqin, Ennion, Steven J
    Publicado 2006
    “…BACKGROUND: P2X(1 )receptors play an important role in platelet function as they can induce shape change, granule centralization and are also involved in thrombus formation. …”
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    Sp1/3 and NF-1 mediate basal transcription of the human P2X(1 )gene in megakaryoblastic MEG-01 cells
  3. 1143
    “…The Wilms’ tumour suppressor protein WT1 plays a central role in the development of the kidney and also other organs. …”
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    Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation
  4. 1144
    “…Based on biochemical assays, we propose a mechanism by which Cas1 plays a similar function to DNA repair protein Fen1 by cleaving branched intermediate structures. …”
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    Cas1 and Fen1 Display Equivalent Functions During Archaeal DNA Repair
  5. 1145
    “…BACKGROUND: The discovery of diketoacid-containing derivatives as inhibitors of HIV-1 Integrase (IN) (IN inhibitors, IINs) has played a major role in validating this enzyme as an important target for antiretroviral therapy. …”
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    HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein
  6. 1146
    “…ScPif1 DNA helicase is the prototypical member of a 5′-to-3′ helicase superfamily conserved from bacteria to human and plays various roles in the maintenance of genomic homeostasis. …”
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    The Bacteroides sp. 3_1_23 Pif1 protein is a multifunctional helicase
  7. 1147
    “…BCG (Bacilli Calmette-Guérin) activates disabled naïve macrophages to M1 macrophages, which act as inflammatory, microbicidal and tumoricidal cells through cell-cell contact and/or the release of soluble factors. …”
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    NMAAP1 Expressed in BCG-Activated Macrophage Promotes M1 Macrophage Polarization
  8. 1148
    “…Here, we study the impact of population-level genetic heterogeneity on the epidemic spread of different strains of H1N1 influenza. For a population with known HLA class-I allele frequency and for a given H1N1 viral strain, we classify individuals into sub-populations according to their level of susceptibility to infection. …”
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    Role of genetic heterogeneity in determining the epidemiological severity of H1N1 influenza
  9. 1149
    “…We show that the Hippo pathway transcriptional coactivators Yap1 and Wwtr1 are specifically localized to the presumptive epidermis and notochord, and play a critical and unexpected role in posterior body extension by regulating Fibronectin assembly underneath the presumptive epidermis and surrounding the notochord. …”
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    Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1
  10. 1150
    “…BACKGROUND: Smads, the homologs of Sma and MAD proteins, play a key role in gene expression regulation in the transforming growth factor-β (TGF-β) signaling pathway. …”
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    Cooperative Assembly of Co-Smad4 MH1 with R-Smad1/3 MH1 on DNA: A Molecular Dynamics Simulation Study
  11. 1151
    “…However, the mechanisms by which BDNF regulates the expression of Arc/Arg3.1 are unclear. In this study, we show that BDNF acts via the ERK1/2 pathway to activate the nuclear kinase mitogen‐ and stress‐activated protein kinase 1 (MSK1). …”
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    MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins
  12. 1152
    “…Mechanosensitive Piezo1 and Piezo2 channels transduce various forms of mechanical forces into cellular signals that play vital roles in many important biological processes in vertebrate organisms. …”
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    A mechanism for the activation of the mechanosensitive Piezo1 channel by the small molecule Yoda1
  13. 1153
    “…Moreover, in those regions Spi-1 acts by binding to multiple motifs tightly clustered and with similar orientation. …”
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    Spi-1/PU.1 activates transcription through clustered DNA occupancy in erythroleukemia
  14. 1154
    por Mirabella, Giovanni
    Publicado 2014
    “…Two executive functions play a major role in generating flexible behaviors: (i) the ability to predict future outcomes of goal-directed actions; and (ii) the ability to cancel them when they are unlikely to accomplish valuable results. …”
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    Should I stay or should I go? Conceptual underpinnings of goal-directed actions
  15. 1155
    “…One of the Affordable Care Act’s (ACA) signature reforms was creating centralized Health Insurance Marketplaces to offer comprehensive coverage in the form of comprehensive insurance complying with the ACA’s coverage standards. …”
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    Same Game, Different Names: Cream-Skimming in the Post-ACA Individual Health Insurance Market
  16. 1156
    “…BACKGROUND AND AIMS: Spinal serum 25-hydroxyvitamin D [25[OH]D] status plays an important role in mediating innate immune responses by acting as a cofactor for induction of antimycobacterial activity and is thus involved in the development of Tuberculosis (TB). …”
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    The Potential Role of Vitamin D in the Development of Tuberculosis in Chinese Han Population: One Case-Control Study
  17. 1157
    “…What would it be like if we said one thing, and heard ourselves saying something else? …”
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    Auditory feedback of one’s own voice is used for high-level semantic monitoring: the “self-comprehension” hypothesis
  18. 1158
    por Delehanty, Abigail, Wetherby, Amy M.
    Publicado 2022
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    Coordinated social communication in toddlers with and without autism spectrum disorder during a home observation
  19. 1159
    “…ARF1A1C localizes to the trans-Golgi network/early endosome and Golgi apparatus, acts synergistically to BEN1/MIN7 ARF GEF and is important for PIN recycling to the PM. …”
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    BEX1/ARF1A1C is Required for BFA-Sensitive Recycling of PIN Auxin Transporters and Auxin-Mediated Development in Arabidopsis
  20. 1160
    “…On the whole, our results indicate that the grapevine VvLYK1‐1 and VvLYK1‐2 participate in chitin‐ and chitosan‐triggered immunity and that VvLYK1‐1 plays an important role in basal resistance against E. necator.…”
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    The grapevine (Vitis vinifera) LysM receptor kinases VvLYK1‐1 and VvLYK1‐2 mediate chitooligosaccharide‐triggered immunity
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