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11681por Barrera, Andrea, Acuña-Rodríguez, Ian S., Ballesteros, Gabriel I., Atala, Cristian, Molina-Montenegro, Marco A.“…Therefore, BSCs would be effectively acting as ecosystem engineers for the terrestrial Antarctic ecosystem.…”
Publicado 2022
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11682por Guerra‐García, Azalea, Rojas‐Barrera, Idalia C., Ross‐Ibarra, Jeffrey, Papa, Roberto, Piñero, Daniel“…The scarlet runner bean (Phaseolus coccineus) is one of the five domesticated Phaseolus species. …”
Publicado 2022
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11683por Ilyas, Ashal, Wijayasinghe, Yasanandana Supunsiri, Khan, Ilyas, El Samaloty, Nourhan M., Adnan, Mohd, Dar, Tanveer Ali, Poddar, Nitesh Kumar, Singh, Laishram R., Sharma, Hemlata, Khan, Shahanavaj“…The elevated plasma TMAO has been reported to be correlated with the pathogenesis of numerous human diseases, including cardiovascular disease, heart failure, kidney diseases, metabolic syndrome, etc.; Hence, TMAO has been recognized as a novel biomarker for the detection/prediction of several human diseases. In contrast, betaine acts as a methyl donor in one-carbon metabolism, maintains cellular S-adenosylmethionine levels, and protects the cells from the harmful effects of increased plasma homocysteine. …”
Publicado 2022
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11684“…Nonetheless, evidence for hybridization in the extant cichlid fauna is scant, suggesting that hybridization is rare in the modern era, perhaps enforced by natural or sexual selection acting against F1 hybrids. Additionally, most experimental studies of hybridization perform a hybrid cross in one direction, ignoring the reciprocal hybrid. …”
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11685Targeting mTOR as a Cancer Therapy: Recent Advances in Natural Bioactive Compounds and Immunotherapypor Bouyahya, Abdelhakim, El Allam, Aicha, Aboulaghras, Sara, Bakrim, Saad, El Menyiy, Naoual, Alshahrani, Mohammed Merae, Al Awadh, Ahmed Abdullah, Benali, Taoufiq, Lee, Learn-Han, El Omari, Nasreddine, Goh, Khang Wen, Ming, Long Chiau, Mubarak, Mohammad S.“…It is an essential protein kinase that belongs to the phosphoinositide-3-kinase (PI3K) family and has two known signaling complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). Even though mTOR signaling plays a critical role in promoting mitochondria-related protein synthesis, suppressing the catabolic process of autophagy, contributing to lipid metabolism, engaging in ribosome formation, and acting as a critical regulator of mRNA translation, it remains one of the significant signaling systems involved in the tumor process, particularly in apoptosis, cell cycle, and cancer cell proliferation. …”
Publicado 2022
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11686por Sakai, Kosuke“…Advice is not a monolithic intervention by which one side acts on the other but is rather an interface that enables the two systems to relate through distancing. …”
Publicado 2023
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11687por Goh, Grace Ying Shyen, Beigi, Arshia, Yan, Junran, Doering, Kelsie R S, Taubert, Stefan“…The micronutrient vitamin B12 is an essential cofactor for two enzymes: methionine synthase, which plays a key role in the one-carbon cycle; and methylmalonyl-CoA mutase, an enzyme in a pathway that breaks down branched-chain amino acids and odd-chain fatty acids. …”
Publicado 2023
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11688por Monfort, Jordi, Tardif, Ginette, Reboul, Pascal, Mineau, François, Roughley, Peter, Pelletier, Jean-Pierre, Martel-Pelletier, Johanne“…This MMP, in addition to initiating collagen fibre cleavage, acts on several proteoglycans. One of the proteoglycan families, termed small leucine-rich proteoglycans (SLRPs), was found to be involved in collagen fibril formation/interaction, with some members playing a role in the OA process. …”
Publicado 2006
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11689“…BACKGROUND: Gene regulation plays a central role in the adaptation of organisms to their environments. …”
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11690
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11691por Miceli, Francesco, Soldovieri, Maria Virginia, Ambrosino, Paolo, De Maria, Michela, Manocchio, Laura, Medoro, Alessandro, Taglialatela, Maurizio“…Given the important functional role played by the VSM in neuronal VGICs, it is not surprising that various VSM mutations affecting the gating process of these channels are responsible for human diseases, and that compounds acting on the VSM have emerged as important investigational tools with great therapeutic potential. …”
Publicado 2015
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11692por Zhou, Jianfei, Song, Tianqi, Zhou, Hongwei, Zhang, Mingfei, Li, Nan, Xiang, Jishan, Zhang, Xiaoke“…Estimation of ROS content, determination of antioxidant enzyme activity, and gene expression analysis in a line overexpressing one typical TaTRX confirmed that TRX plays an important role in maintaining redox balance in wheat. …”
Publicado 2022
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11693“…One of the most important properties of intrinsically disordered proteins is their ability to undergo liquid-liquid phase separation and form droplets. …”
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11694por Qian, Zhenfeng, Rao, Xibing, Zhang, Rongqiong, Gu, Shujie, Shen, Qingqing, Wu, Huaying, Lv, Shaozhi, Xie, Linyan, Li, Xianli, Wang, Xianhong, Chen, Shuying, Liu, Lufeng, He, Lilian, Li, Fusheng“…The AP2/ERF transcription factor family is one of the most important gene families in plants and plays a vital role in plant abiotic stress responses. …”
Publicado 2023
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11695por Sultan, Ahmed, Mohammad, Bassim, Hadi, Najah, AL-Shaibany, Azhar, Philip, Anil, Jamil, Dina, Al-Aubaidy, Hayder“…BACKGROUND AND AIM: Inflammation plays a crucial role in the development of atherosclerotic plague. …”
Publicado 2023
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11696por N. M. Furtado, Ariadne, Leonardi, Marco, Comandini, Ornella, Neves, Maria Alice, C. Rinaldi, Andrea“…Background: The Brazilian Atlantic Forest is one of the most biodiverse terrestrial ecoregions of the world. …”
Publicado 2023
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11697“…The B-box (BBX) protein, which is a zinc-finger protein containing one or two B-box domains, plays a crucial role in the growth and development of plants. …”
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11698por Lin, Huiyuan, Shi, Tingrui, Zhang, Ying, He, Chuyang, Zhang, Qiying, Mo, Zhiping, Pan, Wenqiu, Nie, Xiaojun“…N6-methyladenosine modifications (m6A) is one of the most abundant and prevalent post-transcriptional RNA modifications in plants, playing the crucial role in plant growth and development and stress adaptation. …”
Publicado 2023
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11699por Wehle, Devin T., Bass, Carter S., Sulc, Josef, Mirzaa, Ghayda, Smith, Stephen E.P.“…The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that acts as a central mediator of translation, and plays important roles in cell growth, synaptic plasticity, cancer, and a wide range of developmental disorders. …”
Publicado 2023
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11700por John, Amber, Desai, Roopal, Saunders, Rob, Buckman, Joshua E.J., Brown, Barbara, Nurock, Shirley, Michael, Stewart, Ware, Paul, Marchant, Natalie L., Aguirre, Elisa, Rio, Miguel, Cooper, Claudia, Pilling, Stephen, Richards, Marcus, Gaysina, Darya, Stott, Josh“…The aim of this study was to test: 1) Whether cortisol acts as a pathway in the association between depressive or anxiety symptoms across adulthood and midlife cognitive function; 2) Whether cortisol is associated with later depressive or anxiety symptoms, and cognitive function. …”
Publicado 2022
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