“…However, whether VEGF acts on brain edema following intracerebral hemorrhage (ICH) is largely unknown. …”
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“…BACKGROUND: MiRNA primarily acts to repress gene expression at the post-transcriptional level through imperfect complementarity of its 5′ region to the “seed site” in the 3′ untranslated region of target mRNAs, with its “3′–supplementary site” and “center site” also playing important roles under certain circumstances. …”
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“…Expression analyses performed in the PSLT047-iesR-1-PSLT046 (mig5) region support a cis-acting regulatory mechanism of IesR-1 as antisense RNA over the PSLT047 transcript involving interaction at their respective 3′ ends and modulation of PSLT047 protein levels. …”
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“…Student responses reflected that an “aversion to public speaking” acted as the main deterrent to participating during a lecture. …”
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“…Unlike the previously characterized DDX3-like AtRH20/Ded1p helicases that bind to the 3′ terminal promoter region in the viral minus-strand (−)RNA, the other class of eIF4AIII-like RNA helicases bind to a different cis-acting element, namely the 5′ proximal RIII(−) replication enhancer (REN) element in the TBSV (−)RNA. …”
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“…Using BALB/c mice deficient in A2A ADO receptor (A2(A)R(–/–)), we showed that co-inoculated mice controlled infection, displaying lower parasite numbers at infection sites and reduced iTreg generation. CONCLUSION/SIGNIFICANCE: We have demonstrated that ADO and AMP in P. papatasi saliva mediate exacerbative effects of Leishmania infection by acting preferentially on DCs promoting a tolerogenic profile in DCs and by generating iTregs in inflammatory foci through an A2(A)R mechanism.…”
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“…Both mechanisms also require Hsp90 dissociation previous to nuclear translocation. One mechanism involves phosphorylation of the C-terminal tail of ERK5 by kinases that are activated during mitosis, such as Cyclin-dependent kinase-1. …”
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“…Evidence suggesting that the histamine H(3 )receptor plays a key role in vestibular compensation comes from studies indicating that betahistine, a histamine-like drug that acts as both a partial histamine H(1 )receptor agonist and an H(3 )receptor antagonist, can accelerate the process of vestibular compensation. …”
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“…The hook substructure of the bacterial flagellum acts as a universal joint connecting the motor to the flagellar filament. …”
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“…However, the exact molecular mechanisms underlying these interactions in different non-tumor pathophysiologies vary, and S100A4 is likely one of the cross-linking factors that acts as common intrinsic constituents of biological mechanisms. …”
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“…Starch Synthase (SS) plays an important role in extending the α-1,4 glucan chains during starch biosynthesis by catalyzing the transfer of the glucosyl moiety from ADP-glucose to the non-reducing end of a pre-existing glucan chain. …”
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“…BACKGROUND: Head and neck squamous cell cancer (HNSCC) is one of the most common tumors worldwide and there is an enormous need for innovative therapy approaches. …”
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“…In this paper, we explore one factor that may modulate children's language learning with a peer-like social robot: rapport. …”
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“…In HCC tissues, particularly in IR‐insensitive HCC tissues, miR‐320b expression was significantly downregulated. miR‐320b inhibition also attenuated IR treatment‐induced DNA damage to HCC cells; more importantly, RAD21 silencing significantly attenuated the effects of miR‐320b inhibition on IR treatment‐induced DNA damage, suggesting that miR‐320b plays a role through targeting RAD21. In conclusion, an miR‐320b/RAD21 axis modulating HCC sensitivity to IR treatment through acting on IR‐induced DNA damage was demonstrated. …”
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“…In the heart, the classic RAAS plays a role in both hemodynamics and tissue remodeling associated with cardiomyocyte and endothelial dysfunction, leading to progressive functional impairment. …”
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“…Regarding peers' influence, all players recognized that friends were not only one of the main reasons to start playing volleyball, but also an important source of support to remain engaged and staying motivated to do sport. …”
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“…On the other hand, after the annexinA5 protein was applied to the gastric cancer cells, cell proliferation and metastasis were inhibited, while cell apoptosis and necrosis were promoted. AnnexinA5 played its role via ERK signal pathway. ANXA5 acted as tumor suppressor gene in the gastric cancer by suppressing ERK signal pathway and has the potentiality to be an auxiliary anticancer agent.…”
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“…Most amino acids are coded by more than one synonymous codon, but they are used in a biased manner. …”
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