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  1. 1181
    “…These data indicate that G1-HIF acts as a cell cycle-dependent surveillance factor that prevents the onset of starvation-induced apoptosis.…”
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    A transient increase of HIF-1α during the G1 phase (G1-HIF) ensures cell survival under nutritional stress
  2. 1182
    “…Additionally, genetic knockout of USP1 the survival rate of CTCs. Further analyses showed that USP1 mediates oncogenic activity by deubiquitinating and stabilizing transducin β-like 1 X-linked receptor 1 (TBLR1), which plays essential roles in regulating Wnt signaling. …”
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    USP1 Maintains the Survival of Liver Circulating Tumor Cells by Deubiquitinating and Stabilizing TBLR1
  3. 1183
    “…ADAR1 is frequently amplified and overexpressed in iCCAs and plays oncogenic roles. …”
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    The A-to-I editing of KPC1 promotes intrahepatic cholangiocarcinoma by attenuating proteasomal processing of NF-κB1 p105 to p50
  4. 1184
    “…UHRF1 plays multiple roles in regulating DNMT1-mediated DNA methylation maintenance during DNA replication. …”
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    Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation
  5. 1185
    “…However, the mechanism(s) that maintains the autoinhibitory state of the DDR1 dimers is unknown. Here, we report that N-glycosylation at the Asn(211) residue plays a unique role in the control of DDR1 dimerization and autophosphorylation. …”
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    Glycosylation at Asn(211) Regulates the Activation State of the Discoidin Domain Receptor 1 (DDR1)
  6. 1186
    “…Background: High mobility group box 1 (HMGB1) protein is a damage-associated molecular pattern (DAMP) that plays an important role in the repair and regeneration of tissue injury. …”
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    The Role of High Mobility Group Box 1 (HMGB1) in Neurodegeneration: A Systematic Review
  7. 1187
    “…Previous studies have revealed that the SM protein Munc18-1 plays a critical role for precise SNARE assembly with the help of Munc13-1, but the underlying mechanism remains unclear. …”
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    Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly
  8. 1188
    “…Recently, mitochondrial oxidative stress has been proposed to be associated with ASD. Besides, SIRT1/PGC-1α signaling plays an important role in combating oxidative stress. …”
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    Role of SIRT1/PGC-1α in mitochondrial oxidative stress in autistic spectrum disorder
  9. 1189
    “…Previously, our lab showed that the pathway for synthesizing the phospholipid phosphatidylserine (PS) plays a role in β (1,3)-glucan masking. The homozygous PS synthase knockout mutant, cho1Δ/Δ, exhibits increased exposure of β (1,3)-glucan. …”
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    Exposure of Candida albicans β (1,3)-glucan is promoted by activation of the Cek1 pathway
  10. 1190
    “…Knockdown of PROX1-AS1 gene expression by siRNA could inhibit cell proliferation. …”
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    LncRNA PROX1-AS1 promotes proliferation, invasion, and migration in papillary thyroid carcinoma
  11. 1191
    “…BACKGROUND: The cooling agents menthol and icilin act as agonists at TRPM8 and TRPA1. In vitro, activation of TRPM8 by icilin and cold, but not menthol, is dependent on the activity of a sub-type of phospholipase A2, iPLA2. …”
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    The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity
  12. 1192
    por Hua, Ming, Tao, Ming-Jie, Deng, Fu-Guo
    Publicado 2016
    “…We propose a quantum processor for the scalable quantum computation on microwave photons in distant one-dimensional superconducting resonators. It is composed of a common resonator R acting as a quantum bus and some distant resonators r(j) coupled to the bus in different positions assisted by superconducting quantum interferometer devices (SQUID), different from previous processors. …”
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    Quantum state transfer and controlled-phase gate on one-dimensional superconducting resonators assisted by a quantum bus
  13. 1193
    “…These results suggest that MACC1-AS1 acts as an oncogene in the development of HCC.…”
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    MACC1-AS1 promotes hepatocellular carcinoma cell invasion and proliferation by regulating PAX8
  14. 1194
    “…BACKGROUND: The role of innate immunity in general and of type I interferon (IFN-I) in particular in HTLV-1 pathogenesis is still a matter of debate. …”
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    ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity
  15. 1195
    “…In order to make use of maltotriose, which would otherwise accumulate, disproportionating enzyme 1 (DPE1; a 4-α-glucanotransferase) converts two molecules of maltotriose to a molecule of maltopentaose, which can now be acted on by the degradative enzymes, and one molecule of glucose that can be exported. …”
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    Structural Dissection of the Maltodextrin Disproportionation Cycle of the Arabidopsis Plastidial Disproportionating Enzyme 1 (DPE1)
  16. 1196
    “…One member of this family, the oxoglutarate receptor 1 (OXGR1), may have a crucial role in the heart because it acts as a receptor for α-ketoglutarate, a metabolite that is elevated in heart failure patients. …”
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    The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice
  17. 1197
    “…Overall, our results revealed that the monocarbonyl curcumin derivative DM96 acts as a strong hGSTP1-1 inhibitor, exerts high prostate cancer cell cytotoxicity, and may, therefore, be exploited for the suppression and chemosensitization of cancer cells. …”
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    Monocarbonyl Curcumin Analogues as Potent Inhibitors against Human Glutathione Transferase P1-1
  18. 1198
    “…RATIONALE: TEAD (TEA domain transcription factor) 1—a major effector of the Hippo signaling pathway—acts as an oncoprotein in a variety of tumors. …”
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    TEAD1 (TEA Domain Transcription Factor 1) Promotes Smooth Muscle Cell Proliferation Through Upregulating SLC1A5 (Solute Carrier Family 1 Member 5)-Mediated Glutamine Uptake
  19. 1199
    “…TMPO antisense RNA 1 (TMPO-AS1) has been found to be involved in several cancers by acting as a competing endogenous RNA. …”
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    The Long Non-coding RNA TMPO-AS1 Promotes Bladder Cancer Growth and Progression via OTUB1-Induced E2F1 Deubiquitination
  20. 1200
    “…Finally, dendritic cells exert their adjuvanticity by acting as both antigen donor cells (i.e., antigen reservoirs) as well as antigen presenting cells. …”
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    CD11c(+) MHCII(lo) GM-CSF-bone marrow-derived dendritic cells act as antigen donor cells and as antigen presenting cells in neoepitope-elicited tumor immunity against a mouse fibrosarcoma
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