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  1. 12041
    por Ito, Hiroshi T., Schuman, Erin M.
    Publicado 2007
    “…Here, in recordings from hippocampal slices, we show that DA acts specifically at the direct cortical input to hippocampal area CA1 (the temporoammonic (TA) pathway) to filter the excitatory drive onto pyramidal neurons based on the input frequency. …”
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    Frequency-Dependent Gating of Synaptic Transmission and Plasticity by Dopamine
  2. 12042
    “…The role that dysregulation of this process plays in human disease is also discussed.…”
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    Multiple Export Mechanisms for mRNAs
  3. 12043
    por Itoh, Nobuyuki
    Publicado 2014
    “…FGF21 is mostly induced by different kinds of stress and acts though FGF receptor 1c with β-Klotho as a cofactor in an endocrine or, in parts, autocrine/paracrine manner. …”
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    FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases
  4. 12044
    “…Comparing the fitness of cis- and trans-acting mutations affecting expression of the same gene also confirmed that trans-acting deletions tend to be more deleterious. …”
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    Network Topology Can Explain Differences in Pleiotropy Between Cis- and Trans-regulatory Mutations
  5. 12045
    “…MDC1 also plays a role both in Non-Homologous End Joining (NHEJ) and Homologous Recombination (HR) repair pathways. …”
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    Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs
  6. 12046
    “…In humans, FENDRR is located on chromosome 16q24.1, and is positively regulated both by the FOXF1 distant lung-specific cis-acting enhancer and by trans-acting FOXF1. …”
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    Long Non-Coding RNA FENDRR: Gene Structure, Expression, and Biological Relevance
  7. 12047
    por Ma, Pei, Zhang, Lichang, Dong, Hui, Yu, Jian
    Publicado 2023
    “…DISCUSSION: These findings revealed that deep acting and the expression of naturally felt emotions are positively related to positive emotions and the classroom setting, whereas surface acting plays a negative role in the emotional states of individuals and the classroom. …”
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    The relationships between teachers’ emotional labor and display rules, trait emotions, exhaustion, and classroom emotional climate
  8. 12048
    “…The innate immune response plays a key role in fighting infection by activating inflammation and stimulating the adaptive immune response. …”
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    Regulation of Toll-like Receptor Signaling by the SF3a mRNA Splicing Complex
  9. 12049
    “…Here, we show that specific nucleosome depletion corresponds to well-characterized binding sites for known trans-acting factors, including hepatocyte nuclear factor 1, Forkhead box A1 and CCCTC-binding factor. …”
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    Nucleosome mapping across the CFTR locus identifies novel regulatory factors
  10. 12050
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    Removal of per- and polyfluoroalkyl substances (PFAS) from water by ceric(iv) ammonium nitrate
  11. 12051
    por Gibbs, Marie E.
    Publicado 2016
    “…Endogenous ATP promotion of memory consolidation at 2.5 and 30 min is also dependent on glycogen breakdown. ATP acts at P(2)Y(1) receptors and the action of thrombin suggests that it causes the release of internal calcium ([Ca(2+)](i)) in astrocytes. …”
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    Role of Glycogenolysis in Memory and Learning: Regulation by Noradrenaline, Serotonin and ATP
  12. 12052
    “…Recent evidence suggests that the trait of appetitive aggression plays an important role in the prediction of aggressive behavior. …”
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    Are experiences of family and of organized violence predictors of aggression and violent behavior? A study with unaccompanied refugee minors
  13. 12053
    “…In addition, albumin transports sphingosine-1-phosphate which has protective endothelial effects, acts as a free radical scavenger, and has immunomodulatory and anti-inflammatory effects. …”
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    Role of albumin in the preservation of endothelial glycocalyx integrity and the microcirculation: a review
  14. 12054
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    Maelstrom promotes tumor metastasis through regulation of FGFR4 and epithelial-mesenchymal transition in epithelial ovarian cancer
  15. 12055
    por Goodman, J I, Counts, J L
    Publicado 1993
    “…DNA methylation (i.e., the 5-methylcytosin content of DNA) plays a role in the regulation of gene activity. …”
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    Hypomethylation of DNA: a possible nongenotoxic mechanism underlying the role of cell proliferation in carcinogenesis.
  16. 12056
    por Lechler, Terry, Li, Rong
    Publicado 1997
    “…This finding, together with the severe defects in actin organization associated with the bee1 null mutation, indicates that Bee1 protein plays a direct role in controlling actin polymerization at the cell cortex. …”
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    In Vitro Reconstitution of Cortical Actin Assembly Sites in Budding Yeast
  17. 12057
    “…Here we show that, analogous to the situation in G1 phase, the checkpoint kinase Rad53 inhibits both CDK- and DDK-dependent pathways, which acts redundantly to block further origin firing. …”
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    Checkpoint Dependent Inhibition of DNA Replication Initiation by Sld3 and Dbf4 Phosphorylation
  18. 12058
    “…Unlike ECM surrounding somatic cells, the ZP is composed of only a few glycosylated proteins, ZP1–4, that are unique to oocytes and eggs. ZP1–4 have a large region of polypeptide, the ZP domain (ZPD), consisting of two subdomains, ZP-N and ZP-C, separated by a short linker region, that plays an essential role in polymerization of nascent ZP proteins into crosslinked fibrils. …”
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    Zona Pellucida Genes and Proteins: Essential Players in Mammalian Oogenesis and Fertility
  19. 12059
    “…Obesity has shown to increase the blood levels of insulin, insulin-like growth factor-1 (IGF-1), leptin, resistin, inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1) which in turn acts via various signaling pathways to induce colonic cell proliferation and in turn CRC development. …”
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    Colon Cancer and Obesity: A Narrative Review
  20. 12060
    “…BACKGROUND: Phenylalanine ammonia-lyase (PAL), as a key enzyme in the phenylalanine metabolism pathway in plants, plays an important role in the response to environmental stress. …”
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    Genome-wide identification and expression analysis of phenylalanine ammonia-lyase (PAL) family in rapeseed (Brassica napus L.)
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