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  1. 12081
    “…Moreover, signaling pathways acting during this process are elucidated, with emphasis on signals delivered by TGF-β family members and by Toll-like/IL-1β receptors. …”
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    Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis
  2. 12082
    “…The SIE variability in PAS during the late spring and early summer (i.e., April–May–June, AMJ) plays a key role in determining the SIE during the following fall when SIE is at a minimum. …”
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    Changes in the role of Pacific decadal oscillation on sea ice extent variability across the mid-1990s
  3. 12083
    “…SIN3 acts as a scaffold in the complex, binding directly to HDAC1/2 and other proteins and plays crucial roles in regulating apoptosis, differentiation, cell proliferation, development, and cell cycle. …”
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    SIN-3 functions through multi-protein interaction to regulate apoptosis, autophagy, and longevity in Caenorhabditis elegans
  4. 12084
    “…We hypothesized that drugs acting on Glu transporters, such as ceftriaxone (CEF, 200 mg/kg, i.p.) and N-acetylcysteine (NAC, 150 mg/kg, i.p.), administered repeatedly for 5 days before focal cerebral ischemia in rats and induced by a 90-min middle cerebral artery occlusion (MCAO), may induce brain tolerance to ischemia. …”
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    N-Acetylcysteine and Ceftriaxone as Preconditioning Strategies in Focal Brain Ischemia: Influence on Glutamate Transporters Expression
  5. 12085
    “…This paper discusses the cells recruited by CCL5 in patients with CRC and the specific mechanism of this recruitment, as well as recent clinical studies of CCL5 in patients with CRC. KEY MESSAGES: 1. CCL5 plays dual roles in colorectal cancer progression. 2. …”
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    The regulatory network of the chemokine CCL5 in colorectal cancer
  6. 12086
    “…We investigated the evolutionary pressures acting on almost all human protein-coding genes (N = 11,667; 1:1 orthologs in primates) based on their divergence from those of early hominins, such as Neanderthals, and non-human primates. …”
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    Systematic detection of brain protein-coding genes under positive selection during primate evolution and their roles in cognition
  7. 12087
    “…Interfering with such signaling has been producing exciting results in cancer therapy: just think of anti-PD-1/anti-PD-L1/anti-CTLA-4 antibodies that, acting as immune checkpoint inhibitors, interrupt the inhibitory signaling exerted by cancer cells on immune cells or the CAR-T technology that fosters the reactivation of anti-tumoral immunity in a restricted group of leukemias and lymphomas. …”
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    NGAL as a Potential Target in Tumor Microenvironment
  8. 12088
    “…BACKGROUND: Chemotherapy plays a crucial role in malaria control. However, the main obstacle to treatment has been the rise of parasite resistance to most antimalarial drugs. …”
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    Antimalarial Activity of Nigella sativa L. Seed Extracts and Selection of Resistance in Plasmodium berghei ANKA in a Mouse Model
  9. 12089
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    Opposing presynaptic roles of BDNF and ProBDNF in the regulation of persistent activity in the entorhinal cortex
  10. 12090
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    Long noncoding RNAs: glycolysis regulators in gynaecologic cancers
  11. 12091
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    Pontin/Tip49 negatively regulates JNK-mediated cell death in Drosophila
  12. 12092
    “…PGK1 also plays a role as a transcription factor once transported into the nucleus. …”
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    Resistance to anoikis in transcoelomic shedding: the role of glycolytic enzymes
  13. 12093
    “…In the present study, we showed that pI215L acts as an E2-ubiquitin like enzyme in a large range of pH values and temperatures, after short incubation times. …”
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    African swine fever virus encodes for an E2-ubiquitin conjugating enzyme that is mono- and di-ubiquitinated and required for viral replication cycle
  14. 12094
    “…Abrogation of polη SUMOylation results in replication defects in response to mild replication stress, leading to chromosome fragments in mitosis and damage transmission to daughter cells. Rad18 plays a pivotal role, independently of its ubiquitin ligase activity, acting as a molecular bridge between polη and the PIAS1 SUMO ligase to promote polη SUMOylation. …”
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    Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA
  15. 12095
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    Targeting dePARylation for cancer therapy
  16. 12096
    “…Twenty-nine years following the breakthrough discovery that a single-gene mutation of daf-2 doubles Caenorhabditis elegans lifespan, it remains unclear where this insulin/IGF-1 receptor gene is expressed and where it acts to regulate ageing. …”
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    Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost
  17. 12097
    “…The results of the study concluded that the NVU is an ideal target and TCHi acts as a neuroprotective agent against cerebral I/R injuries.…”
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    Troxerutin and Cerebroprotein Hydrolysate Injection Protects Neurovascular Units from Oxygen-Glucose Deprivation and Reoxygenation-Induced Injury In Vitro
  18. 12098
    “…Cluster of differentiation 36 (CD36) is a member of the class B scavenger receptor family that is involved in importing fatty acids into cells. CD36 plays a role in tumor angiogenesis by binding to its ligand, thrombospondin-1 (TSP-1), and then interacting with transforming growth factor beta 1 (TGFβ1). …”
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    Nobiletin Inhibits CD36-Dependent Tumor Angiogenesis, Migration, Invasion, and Sphere Formation Through the Cd36/Stat3/Nf-Κb Signaling Axis
  19. 12099
    “…The redox cycling of Cu(II)/Cu(I) and oxidized sulfur (SO(x)(2–)) species on the surface of CuS NPs played a major role for the activation of SO(3)(2–) and generation and transformation of a sulfite radical ((•)SO(3)(–)) into a sulfate radical ((•)SO(4)(–)). …”
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    CuS Nanoparticles Trigger Sulfite for Fast Degradation of Organic Dyes under Dark Conditions
  20. 12100
    “…Delta-9-tetrahydrocanabinol (THC), the principal psychoactive component in marijuana, acts as a partial agonist of the cannabinoid type 1 receptor (CB1R). …”
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    Long-term consequences of adolescent cannabinoid exposure in adult psychopathology
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