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  1. 12101
    “…α-Neoagarobiose (NAB)/neoagarooligosaccharide (NAO) hydrolase plays an important role as an exo-acting 3,6-anhydro-α-(1,3)-L-galactosidase in agarose utilization. …”
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    Characterization of Neoagarooligosaccharide Hydrolase BpGH117 from a Human Gut Bacterium Bacteroides plebeius
  2. 12102
    por Wong, Marty Kwok-Shing
    Publicado 2021
    “…Angiotensin converting enzyme (ACE) is well known for its dual actions to convert inactive Ang I to active Ang II, and degrades active bradykinin (BK), which plays an important role in controlling blood pressure. …”
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    Angiotensin converting enzyme
  3. 12103
    “…INTRODUCTION: Studies have shown that rumination plays a significant mediating role between dispositional mindfulness (DM) and psychopathological symptoms in both clinical and non-clinical populations. …”
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    Dispositional Mindfulness and Psychotic Symptoms in Schizophrenia Spectrum Disorders: The Mediating Roles of Rumination and Negative Emotion
  4. 12104
    “…Molecular docking showed that Glycyrol, Phaseol and Glyasperin F in licorice may playe a role in treating COVID-19 by acting on STAT3, IL2RA, MMP1, and CXCL8. …”
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    Exploring the mechanism of action of licorice in the treatment of COVID-19 through bioinformatics analysis and molecular dynamics simulation
  5. 12105
    por Colozza, Gabriele
    Publicado 2021
    “…Recently, a novel secreted, organizer-specific Wnt inhibitor, Bighead, was identified that acts by downregulating Lrp6 plasma membrane levels. …”
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    Purified Bighead protein efficiently promotes head development in the South African clawed frog, Xenopus laevis
  6. 12106
    por Otarigho, Benson, Aballay, Alejandro
    Publicado 2020
    “…Cholesterol acts through NHR-8 to transcriptionally regulate immune genes that are controlled by conserved immune pathways, including a p38/PMK-1 MAPK pathway, a DAF-2/DAF-16 insulin pathway, and an Nrf/SKN-1 pathway. …”
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    Cholesterol Regulates Innate Immunity via Nuclear Hormone Receptor NHR-8
  7. 12107
    Publicado 1995
    “…The results suggest that anti-IgM plays a decisive role in inducing tumor dormancy to BCL1 by acting as an agonist of IgM-mediated signal transduction pathways.…”
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    Tumor dormancy and cell signaling. II. Antibody as an agonist in inducing dormancy of a B cell lymphoma in SCID mice
  8. 12108
    “…Recent advances of electrophysiological measures, e.g., event-related potentials, and their imaging have provided insights into facilitative effects on cognition of some AAPDs acting directly or indirectly on 5-HT(1A) receptors. …”
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    Neural Basis for the Ability of Atypical Antipsychotic Drugs to Improve Cognition in Schizophrenia
  9. 12109
    “…Remarkably, APIP5 acts as an RNA-binding protein to regulate mRNA turnover of the cell death- and defense-related genes OsLSD1 and OsRac1. …”
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    APIP5 functions as a transcription factor and an RNA-binding protein to modulate cell death and immunity in rice
  10. 12110
    “…These lead compounds were fast-acting: re-expression occurred by 12-24 hours. Reactivation of silenced genes was accompanied by depletion of DNMT1 at the promoters of activated genes and demethylation of DNA. …”
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    DNA-intercalators Causing Rapid Re-expression of Methylated and Silenced Genes in Cancer Cells
  11. 12111
    “…A recent study by Laplante et al.[3], using deletion mutants of myp2 and myo51 and the mis-sense mutant myo2-E1 [4], concluded that each myosin has distinct functions and proposed that Myp2p plays the dominant role in actomyosin ring contraction. …”
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    Myo2p is the major motor involved in actomyosin ring contraction in fission yeast
  12. 12112
    por Aditya, Suruchi, Rattan, Aditya
    Publicado 2012
    “…It acts via three receptor subtypes—V(1)a, V(1)b, and V(2)—distributed widely throughout the body. …”
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    Vaptans: A new option in the management of hyponatremia
  13. 12113
    por Ke, Po-Yuan
    Publicado 2023
    “…Autophagy plays a homeostatic role in regulating cellular metabolism by degrading unwanted intracellular materials and acts as a host defense mechanism by eliminating infecting pathogens, such as viruses. …”
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    Crosstalk between Autophagy and RLR Signaling
  14. 12114
    “…As a major component of the extracellular matrix, hyaluronan (HA) plays an important role in defining the biochemical and biophysical properties of tissues. …”
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    The cell surface hyaluronidase TMEM2 is essential for systemic hyaluronan catabolism and turnover
  15. 12115
    “…Ultimately, mindfulness facets negatively predicted the perceived stress levels, which in turn, predicted burnout. However, mindfulness plays different roles in the early stages of burnout syndrome (i.e., frenetic and under-challenged).…”
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    Testing the Intermediary Role of Perceived Stress in the Relationship between Mindfulness and Burnout Subtypes in a Large Sample of Spanish University Students
  16. 12116
    por Jiang, Hongyu, Zhang, Zongde
    Publicado 2023
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    Immune response in influenza virus infection and modulation of immune injury by viral neuraminidase
  17. 12117
    “…It acts directly on the regulation of helper T lymphocytes 1 (Th1) and helper T lymphocytes 2 (Th2) cells, and regulatory T lymphocytes. …”
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    The role of vitamin D in the severity and control of asthma in children and adolescents: A protocol for systematic review and meta-analysis
  18. 12118
    “…Except for its role in the production of adenosine triphosphate (ATP), NAD(+) acts as a substrate for several enzymes including sirtuin 1 (SIRT1) and poly ADP-ribose polymerase 1 (PARP1). …”
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    The Role of Nicotinamide in Cancer Chemoprevention and Therapy
  19. 12119
    por Roman-Trufero, Monica, Dillon, Niall
    Publicado 2022
    “…UBE2D enzymes also function in transcriptional control by acting as donors for ubiquitination of histone tails by the Polycomb protein Ring1B and the DNA methylation regulator UHRF1 as well as having roles in DNA repair and regulation of the level of the tumour suppressor p53. …”
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    The UBE2D ubiquitin conjugating enzymes: Potential regulatory hubs in development, disease and evolution
  20. 12120
    “…In immunotherapy, the gut microbiome plays an important role in cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) blockade, programmed cell death protein 1 (PD-L1) mediation, and T cell stimulation. …”
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    Gut Microbiome: A Promising Biomarker for Immunotherapy in Colorectal Cancer
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