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  1. 12121
    “…Our results revealed that MINE/PDX3 likely plays a role in the conversion of the auxin precursor tryptophan to indole-3-pyruvic acid in the auxin biosynthesis pathway, in which TAA1 (TRYPTOPHAN AMINOTRANSFERASE OF ARABIDOPSIS 1) and its related genes (TRYPTOPHAN AMINOTRANSFERASE RELATED 1 and 2; TAR1 and TAR2) are involved. …”
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    Involvement of Pyridoxine/Pyridoxamine 5′-Phosphate Oxidase (PDX3) in Ethylene-Induced Auxin Biosynthesis in the Arabidopsis Root
  2. 12122
    “…Through mutagenesis and inhibitory studies, we revealed that ERK1/2 acted as an upstream signaling molecule in AP-1 activation, and AKT acted as an upstream signaling molecule in NF-κB activation, which in turn attenuated IL-8 expression. …”
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    Piperine Attenuates Lithocholic Acid-Stimulated Interleukin-8 by Suppressing Src/EGFR and Reactive Oxygen Species in Human Colorectal Cancer Cells
  3. 12123
    “…We found that in all three country groups, meeting the End TB goals by 2030 will require a combination of interventions acting at stages of the TB care cascade. Specific priorities may depend on country settings, for example with public-private mix playing an important role in countries in South Asia and elsewhere. …”
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    Meeting the 2030 END TB goals in the wake of COVID-19: A modelling study of countries in the USAID TB portfolio
  4. 12124
    “…Vascular endothelial growth factor (VEGF) is an angiogenic growth factor that acts primarily on endothelial cells, but numerous studies suggest that VEGF also acts on non-endothelial cells, including trophoblast cells. …”
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    VEGF Maintains Maternal Vascular Space Homeostasis in the Mouse Placenta through Modulation of Trophoblast Giant Cell Functions
  5. 12125
    por Liu, Shaojuan, He, Liuqin, Yao, Kang
    Publicado 2018
    “…Alpha-ketoglutarate (AKG) is a crucial intermediate of the Krebs cycle and plays a critical role in multiple metabolic processes in animals and humans. …”
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    The Antioxidative Function of Alpha-Ketoglutarate and Its Applications
  6. 12126
    “…WNT4 is also necessary for decidual cell differentiation and decidualization, which plays an important role in preeclampsia. WNT4 promotes neuronal differentiation of neural stem cell and dendritic cell (DC) into conventional type 1 DC (cDC1). …”
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    Roles and action mechanisms of WNT4 in cell differentiation and human diseases: a review
  7. 12127
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    Prevention of malignant digestive system tumors should focus on the control of chronic inflammation
  8. 12128
    “…Here we report three cryo-electron microscopy structures of G(i1) protein-coupled CCR5 in a ligand-free state and in complex with the chemokine MIP-1α or RANTES, as well as the crystal structure of MIP-1α-bound CCR5. …”
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    Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5
  9. 12129
    “…SMAD3 binds to CNS1 region and acts as transcription inducer, whereas GATA3 plays a temporal role in the FOXP3 transcription by differential chromatin modification in CNS regions. …”
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    Transcriptional regulation of FOXP3 requires integrated activation of both promoter and CNS regions in tumor-induced CD8(+) Treg cells
  10. 12130
    “…Attenuating chromosomal movement in fkb-6 mutants partially restores the defects in synapsis, in agreement with FKB-6 acting by decreasing chromosomal movement. Therefore, we suggest that FKB-6 plays a role in regulating dynein movement by preventing excess chromosome movement, which is essential for proper SC assembly and homologous chromosome pairing.…”
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    Regulating chromosomal movement by the cochaperone FKB-6 ensures timely pairing and synapsis
  11. 12131
    Publicado 1996
    “…As a step toward defining the molecular mechanisms responsible for the regulation of type XI collagen expression, we characterized the promoter region of the mouse alpha 2(XI) collagen gene (Coll1a2). We also generated transgenic mice harboring various fragments of the promoter and the first intron of Coll1a2 linked to the Escherichia coli beta-galactosidase gene to identify the cis-acting elements responsible for tissue- and site-specific expression during development. …”
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    Separable cis-regulatory elements that contribute to tissue- and site- specific alpha 2(XI) collagen gene expression in the embryonic mouse cartilage
  12. 12132
    “…UPF2 acts as an adaptor between Stau1 and UPF1, stimulates the catalytic activity of UPF1 and plays a central role in the formation of an SMD-competent mRNP. …”
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    Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP
  13. 12133
    “…We also recently found that the autophagy-related gene-related protein Ambra1 plays an important role in the autophagy pathway in CRC cells. …”
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    Downregulation of Enhancer of Zeste Homolog 2 (EZH2) is essential for the Induction of Autophagy and Apoptosis in Colorectal Cancer Cells
  14. 12134
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    Caudal DMN neurons innervate the spleen and release CART peptide to regulate neuroimmune function
  15. 12135
    por Lubarski Gotliv, Irina
    Publicado 2016
    “…FXYD5 (Dysadherin, RIC) is a single span type I membrane protein that plays multiple roles in regulation of cellular functions. …”
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    FXYD5: Na(+)/K(+)-ATPase Regulator in Health and Disease
  16. 12136
    por Noda, Nobuo N., Wang, Zheng, Zhang, Hong
    Publicado 2020
    “…Liquid-like condensates can transition into gel and solid states, which are essential for fulfilling their different functions. LLPS plays important roles in multiple steps of autophagy, mediating the assembly of autophagosome formation sites, acting as an unconventional modulator of TORC1-mediated autophagy regulation, and triaging protein cargos for degradation. …”
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    Liquid–liquid phase separation in autophagy
  17. 12137
    “…Taken together, these data indicate that the obestatin signaling acts on muscle fiber-type program in skeletal muscle.…”
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    Obestatin controls skeletal muscle fiber-type determination
  18. 12138
    “…The switch/sucrose nonfermentable (SWI/SNF) family of proteins acts to regulate chromatin accessibility and plays an essential role in multiple cellular processes. …”
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    Structural Insights into the Evolutionarily Conserved BAF Chromatin Remodeling Complex
  19. 12139
    por Liu, Yiwen, Gong, Yan, Xu, Gaosi
    Publicado 2023
    “…In the glomeruli and tubulointerstitium, M1 accounted for 85.41% in the M classification according to the Oxford MEST-C, while in the blood, M1 accounted for 100%, and the patients with low CD89(+) monocyte mean fluorescence intensity displayed more severe pathological characteristics (S1 and T1-2) and clinical symptoms. …”
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    The role of mononuclear phagocyte system in IgA nephropathy: pathogenesis and prognosis
  20. 12140
    “…Furthermore, Notch1 activation via overexpressing Notch1 active form ICN1 induced HCC cell proliferation and anti-apoptosis, indicating Notch signaling played an oncogenic role in HCC cells. …”
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    The Histone Deacetylase Inhibitor Vaproic Acid Induces Cell Growth Arrest in Hepatocellular Carcinoma Cells via Suppressing Notch Signaling
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