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  1. 12141
    “…BACKGROUND: Oxidative stress plays a key role in atherosclerosis. Acting via high level of reactive oxygen species, an increase of oxidative stress is involved in the pathogenesis and progression of atherosclerostic stenosis or occlusion of arteries. …”
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    Evaluation of Oxidative Status in Elderly Patients with Multiple Cerebral Infarctions and Multiple Chronic Total Coronary Occlusions
  2. 12142
    por Lan, Hui Yao
    Publicado 2011
    “…Interestingly, while mice overexpressing active TGF-β1 develop progressive renal injury, latent TGF-β1 plays a protective role in renal fibrosis and inflammation. …”
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    Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation
  3. 12143
    “…Signal transducer and activator of transcription-3 (STAT3) plays an important role in biological balance. Our and others previous studies implied that STAT3 had a great effect on fast-acting innate immunity against tuberculosis (TB). …”
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    Genetics and Functional Mechanisms of STAT3 Polymorphisms in Human Tuberculosis
  4. 12144
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    A circular RNA Edis-Relish-castor axis regulates neuronal development in Drosophila
  5. 12145
    “…We also observed the serine transport activity of LIV-I, which was much lower compared with that of the dedicated SdaC carrier, indicating that LIV-I plays a minor role in the serine uptake. …”
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    A study on L-threonine and L-serine uptake in Escherichia coli K-12
  6. 12146
    “…In conclusion, the data suggest that VPA could be a promising drug to modulate the gene expression in FA cells, confirming that the antioxidant response modulation plays a pivotal in FA pathogenesis as it acts on both oxidative stress levels and the mitochondrial metabolism and dynamics quality.…”
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    Effects of Deacetylase Inhibition on the Activation of the Antioxidant Response and Aerobic Metabolism in Cellular Models of Fanconi Anemia
  7. 12147
    “…Here we show that Cic-L acts in two capacities during Drosophila oogenesis: 1) as a canonical sensor of RTK signaling in somatic follicle cells, and 2) as a regulator of postmitotic growth in germline nurse cells. …”
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    Noncanonical function of Capicua as a growth termination signal in Drosophila oogenesis
  8. 12148
    “…Active BCR related (ABR) gene deactivates ras-related C3 botulinum toxin substrate 1 (RAC1), which plays an essential role in regulating normal hematopoiesis and in leukemia. …”
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    ABR, a novel inducer of transcription factor C/EBPα, contributes to myeloid differentiation and is a favorable prognostic factor in acute myeloid leukemia
  9. 12149
    “…Our findings also revealed that miR-3613-5p plays an oncogenic role in LUAD by promoting cell proliferation and acting as a key regulator of the positive feedback loop underlying the link between the NF-κB/RELA and AKT/MAPK pathways.…”
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    MicroRNA-3613-5p Promotes Lung Adenocarcinoma Cell Proliferation through a RELA and AKT/MAPK Positive Feedback Loop
  10. 12150
    por Grabowski, Sławomir J.
    Publicado 2017
    “…MP2/aug-cc-pVTZ calculations were performed for complexes of BrF(3) and BrF(5) acting as Lewis acids through the bromine centre, with species playing a role of Lewis base: dihydrogen, acetylene, ethylene, and benzene. …”
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    New Type of Halogen Bond: Multivalent Halogen Interacting with π- and σ-Electrons
  11. 12151
    “…While IL-12 plays a key role in differentiation of protective CD4(+) Th1 response, little is known about mechanisms whereby IL-12 differentiates other T-cell populations. …”
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    IL-12 Expands and Differentiates Human Vγ2Vδ2 T Effector Cells Producing Antimicrobial Cytokines and Inhibiting Intracellular Mycobacterial Growth
  12. 12152
    “…Most interestingly, Pentagone, an important secreted feedback regulator of the pathway, plays a central role in scaling and acts as an expander of the Dpp gradient during disc growth.…”
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    Dpp Signaling Activity Requires Pentagone to Scale with Tissue Size in the Growing Drosophila Wing Imaginal Disc
  13. 12153
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    Strand-specific RNA-seq based identification and functional prediction of drought-responsive lncRNAs in cassava
  14. 12154
    por Aitchison, John D., Rout, Michael P.
    Publicado 2012
    “…This transport is regulated at multiple levels, and the NPC itself also plays a key regulatory role in gene expression by influencing nuclear architecture and acting as a point of control for various nuclear processes. …”
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    The Yeast Nuclear Pore Complex and Transport Through It
  15. 12155
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    Untangling human milk oligosaccharides and infant gut microbiome
  16. 12156
    por Forlani, Greta, Accolla, Roberto S.
    Publicado 2017
    “…Within this frame, a peculiar role is played by restriction factors (RFs), elements of intrinsic immunity that interfere with viral life cycle. …”
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    Tripartite Motif 22 and Class II Transactivator Restriction Factors: Unveiling Their Concerted Action against Retroviruses
  17. 12157
    “…The expression of OPN occurs in various tissues and cells, including intestinal epithelial cells and immune cells such as macrophages, dendritic cells, and T lymphocytes. OPN plays an important role in the efficient development of T helper 1 immune responses and cell survival by inhibiting apoptosis. …”
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    Is Osteopontin a Friend or Foe of Cell Apoptosis in Inflammatory Gastrointestinal and Liver Diseases?
  18. 12158
    “…As a plant-specific transcription factor, the NAC (NAM, ATAF1/2 and CUC2) domain protein plays an important role in plant growth and development, as well as stress resistance. …”
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    Genome-Wide Analysis of the NAC Domain Transcription Factor Gene Family in Theobroma cacao
  19. 12159
    por Thoms, Hazel C., Stark, Lesley A.
    Publicado 2021
    “…We will discuss apoptosis mediated by nucleolar sequestration of RelA and new data demonstrating a role for p62 (sequestosome (SQSTM1)) in this process. We will also discuss activation of NF-κB signalling by degradation of the RNA polymerase I (PolI) complex component, transcription initiation factor-IA (TIF-IA (RRN3)), and contexts where TIF-IA-NF-κB signalling may be important. …”
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    The NF-κB Nucleolar Stress Response Pathway
  20. 12160
    “…Here we report that the novel protein kinase C isoform, PKCθ, plays an important role in negatively regulating Ca(2+) signaling downstream of the major collagen receptor, glycoprotein VI (GPVI). …”
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    Protein Kinase Cθ Negatively Regulates Store-independent Ca(2+) Entry and Phosphatidylserine Exposure Downstream of Glycoprotein VI in Platelets
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