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12161por Liu, Ruiqi, Liang, Guoyan, Gong, Jiaxin, Wang, Jiali, Zhang, Yanjie, Hao, Zhiqiang, Li, Guanglin“…Yeast two-hybrid and PP2C inhibition assays show that SLG1 acts as a potent activator of multiple ABA receptors in A. thaliana. …”
Publicado 2023
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12162por Kaur, Rajwinder, Sood, Ankita, Kanotra, Muskan, Arora, Sandeep, Subramaniyan, Vetriselvan, Bhatia, Saurabh, Al-Harrasi, Ahmed, Aleya, Lotfi, Behl, TapanEnlace del recurso
Publicado 2021
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12163“…Further, p53 protein is responsible not only for the expression of miRNAs but also acts as a target molecule for miRNAs and plays a crucial function in the AA-UTUC pathogenicity through activation of cyclin-dependent kinase (CyclinD1) and cyclin protein kinase 6(CDK6) to support cell cycle arrest. …”
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12164por Olloquequi, Jordi, Ettcheto, Miren, Cano, Amanda, Fortuna, Ana, Bicker, Joana, Sánchez-Lopez, Elena, Paz, Cristian, Ureña, Jesús, Verdaguer, Ester, Auladell, Carme, Camins, Antoni“…Moreover, Lico-A inhibits c-Jun N-terminal kinase 1, a key enzyme involved in tau phosphorylation, and modulates the brain insulin receptor, which plays a role in cognitive processes. …”
Publicado 2023
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12165“…γ-Glutamyl-cysteinyl-glycine (GSH) plays a critical role in maintaining redox homeostasis in biological systems and a decrease in its cellular levels is associated with diseases. …”
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12166por Liu, Tengfei, Larionova, Irina, Litviakov, Nikolay, Riabov, Vladimir, Zavyalova, Marina, Tsyganov, Matvey, Buldakov, Mikhail, Song, Bin, Moganti, Kondaiah, Kazantseva, Polina, Slonimskaya, Elena, Kremmer, Elisabeth, Flatley, Andrew, Klüter, Harald, Cherdyntseva, Nadezhda, Kzhyshkowska, Julia“…Mechanistically, stabilin-1 directly interacted with YKL-39 and acted as sorting receptor for targeting YKL-39 into the secretory pathway. …”
Publicado 2018
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12167“…ACh is critical both for proper circuit development and organization, and for optimal functioning of mature systems in both cortical regions. ACh acts through both nicotinic and muscarinic receptors, which show very different expression profiles in V1 vs. dlPFC, and differing effects on neuronal firing. …”
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12168por Namba, Takushi“…The endoplasmic reticulum (ER) is composed of large membrane-bound compartments, and its membrane subdomain appears to be in close contact with mitochondria via ER-mitochondria contact sites. Here, I demonstrate that the ER membrane protein, BAP31, acts as a key factor in mitochondrial homeostasis to stimulate the constitution of the mitochondrial complex I by forming an ER-mitochondria bridging protein complex. …”
Publicado 2019
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12169por Cesana, Marcella, Cacchiarelli, Davide, Legnini, Ivano, Santini, Tiziana, Sthandier, Olga, Chinappi, Mauro, Tramontano, Anna, Bozzoni, Irene“…Here we identify a muscle-specific long noncoding RNA, linc-MD1, which governs the time of muscle differentiation by acting as a ceRNA in mouse and human myoblasts. …”
Publicado 2011
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12170“…Urotensin II (UII) binds to its receptor, UT, playing an important role in the heart, kidneys, pancreas, adrenal gland, and central nervous system. …”
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12171“…Members of the highly conserved Arf family of small GTPases serve as master regulators of vesicular transport. In yeast, Arf1 acts at the Golgi and trans-Golgi network (TGN) to recruit vesicular coat proteins and other effectors for both anterograde and retrograde transport. …”
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12172“…The up-regulation of DFO-induced IL-8 expression was higher in IHOK cells than in HN12 cells and was concentration-dependent. DFO acted additively with IL-1β to strongly up-regulate IL-8 in IHOK cells but not in HN12 cells. …”
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12173por Chen, Shimin, Lin, Jichun, Zhao, Jiaojiao, Lin, Qian, Liu, Jia, Wang, Qiang, Mui, Ryan, Ma, Leina“…FBXW7 (F-box and WD repeat domain containing 7) is a critical subunit of the Skp1-Cullin1-F-box protein (SCF), acting as an E3 ubiquitin ligase by ubiquitinating targeted protein. …”
Publicado 2023
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12174“…As a member of the nuclear receptor (NR) superfamily, pregnane X receptor (PXR; NR1I2) is a ligand-activated transcription factor that plays a crucial role in the metabolism of xenobiotics and endobiotics in mammals. …”
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12175“…Patients’ anxiety, self-efficacy, and sleep quality played intermediary roles incorrelations between empathy and IL6. …”
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12176por Wang, Jinyan, Wang, Jinqiu, Gu, Quan, Ma, Yajun, Yang, Yan, Zhu, Jing, Zhang, Quan’anEnlace del recurso
Publicado 2020
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12177por Zapata-Cachafeiro, Maruxa, Prieto-Campo, Ángela, Portela-Romero, Manuel, Carracedo-Martínez, Eduardo, Lema-Oreiro, Martina, Piñeiro-Lamas, María, Chaudhuri, Somnath, Salgado-Barreira, Ángel, Figueiras, Adolfo“…RESULTS: The consumption of antivitamin K and direct-acting anticoagulants apparently was not associated with the risk of progression to severe COVID-19 (OR 0.93 [95% CI 0.74–1.17] and OR 1.04 [95% CI 0.79–1.36], respectively). …”
Publicado 2022
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12178por Huarte, Nerea, Carravilla, Pablo, Cruz, Antonio, Lorizate, Maier, Nieto-Garai, Jon A., Kräusslich, Hans-Georg, Pérez-Gil, Jesús, Requejo-Isidro, Jose, Nieva, José L.“…By combining two-photon excited Laurdan fluorescence imaging and atomic force microscopy, we have obtained unprecedented insights into the phase state of membranes reconstituted from viral lipids (i.e., extracted from infectious HIV-1 particles), established the role played by the different specimens in the mixtures, and characterized the effects of membrane-active virucidal agents on membrane organization. …”
Publicado 2016
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12179
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12180Publicado 1993“…Costimulation of Th2 cells via CD28 appears to involve the induction of IL-1 production by Th2 cells, which acts in an autocrine fashion to induce IL-4 responsiveness. …”
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