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  1. 1201
    “…Our study clearly showed that TWIK-1/TREK-1-heterodimeric channels can act as the main molecular machinery of astrocytic passive conductance, and suggested that spadin can be used as a specific inhibitor to control astrocytic passive conductance.…”
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    Spadin Modulates Astrocytic Passive Conductance via Inhibition of TWIK-1/TREK-1 Heterodimeric Channels
  2. 1202
    Publicado 1992
    Video VHS
    Los amigos apasionados
  3. 1203
    “…BRG1 is one of two catalytic subunits of the SWI/SNF ATP-dependent chromatin-remodeling complex. …”
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    BRG1: Promoter or Suppressor of Cancer? The Outcome of BRG1’s Interaction with Specific Cellular Pathways
  4. 1204
    “…During the last decade, there has been a growing interest in the roles that the CX3CL1/CX3CR1 signaling pathway plays in the neuropathology of a diverse array of brain disorders. …”
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    The Impact of the CX3CL1/CX3CR1 Axis in Neurological Disorders
  5. 1205
    “…BRCA1-BARD1 acts through a histone intermediate, altering acetylation of histone H4K8 and recruitment of the chromatin reader and oncogene regulator BRD4. …”
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    BRCA1-BARD1 regulates transcription through BRD4 in Xenopus nucleoplasmic extract
  6. 1206
    “…Gfi-1B (growth factor independence-1B) gene is an erythroid-specific transcription factor, whose expression plays an essential role in erythropoiesis. …”
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    GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells
  7. 1207
    “…In summary, Pellino 1 expression acts as an inhibitory signal of the homeostatic regulation of mitotic cell cycle and checkpoint, and thus contributes to the initiation and progression of neoplastic chromosome aneuploidy.…”
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    Pellino 1 inactivates mitotic spindle checkpoint by targeting BubR1 for ubiquitinational degradation
  8. 1208
    “…The endocannabinoid system (ECS) acts as a negative feedback mechanism to suppress synaptic transmission and plays a major role in a diverse range of brain functions including, for example, the regulation of mood, energy balance, and learning and memory. …”
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    Protein Interactors and Trafficking Pathways That Regulate the Cannabinoid Type 1 Receptor (CB1R)
  9. 1209
    “…NR1D1 acts on calcium homeostasis by repressing the SERCA inhibitor myoregulin through direct binding to its promoter. …”
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    NR1D1 controls skeletal muscle calcium homeostasis through myoregulin repression
  10. 1210
    “…These results indicate that Sko1 acts as a repressor of virulence related genes, concluding that Sko1 plays a relevant role during commensalism and systemic infection.…”
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    Deletion of the SKO1 Gene in a hog1 Mutant Reverts Virulence in Candida albicans
  11. 1211
    por Kadota, Shinichi, Nagata, Kyosuke
    Publicado 2014
    “…Furthermore, histone H1 KD also increased ISG transcript. TAF-I and histone H1 double KD did not show the additive effect in ISG transcription, suggesting that TAF-I and histone H1 may act on the same regulatory pathway to control ISG transcription. …”
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    Silencing of IFN-stimulated gene transcription is regulated by histone H1 and its chaperone TAF-I
  12. 1212
    “…Whether mTOR signaling plays a cell-autonomous and/or non-cell-autonomous role in DISC1-dependent regulation of neuronal development is not clear. …”
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    Rheb1 mediates DISC1-dependent regulation of new neuron development in the adult hippocampus
  13. 1213
    “…We also show that TEX19.1 likely acts, at least in part, through promoting the activity of the E3 ubiquitin ligase UBR2 towards L1-ORF1p. …”
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    Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells
  14. 1214
    “…HMGB1, a highly conserved nonhistone DNA-binding protein, plays an important role in inflammatory diseases. …”
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    Salidroside Inhibits HMGB1 Acetylation and Release through Upregulation of SirT1 during Inflammation
  15. 1215
    “…We also showed evidence that PROK1 acting via PROKR1 increased trophoblast cell proliferation and adhesion. …”
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    Prokineticin 1–prokineticin receptor 1 signaling in trophoblast promotes embryo implantation and placenta development
  16. 1216
    “…High-mobility group A1 (HMGA1) acts as a transcription factor in several cardiovascular diseases. …”
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    High-Mobility Group A1 Promotes Cardiac Fibrosis by Upregulating FOXO1 in Fibroblasts
  17. 1217
    “…In the brain, insulin-like growth factor (IGF-I) plays a critical role during development as a neurotrophic and neuroprotective factor, and in tumorigenesis, as IGF-I receptor is often activated in medulloblastomas. …”
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    Developmental and oncogenic effects of Insulin-like Growth Factor-I in Ptc1(+/- )mouse cerebellum
  18. 1218
    “…Oncogenesis in breast cancer often requires the overexpression of the nuclear receptor coactivator AIB1/SRC-3 acting in conjunction with estrogen receptor-α (ERα). …”
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    CK1δ modulates the transcriptional activity of ERα via AIB1 in an estrogen-dependent manner and regulates ERα–AIB1 interactions
  19. 1219
    “…BACKGROUND: Vitiligo is a depigmenting disorder resulting from loss of functional melanocytes in the skin. NPY plays an important role in induction of immune response by acting on a variety of immune cells. …”
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    Association of Neuropeptide Y (NPY), Interleukin-1B (IL1B) Genetic Variants and Correlation of IL1B Transcript Levels with Vitiligo Susceptibility
  20. 1220
    “…Here we demonstrate that RASSF1A acts as an inhibitor of ERα-driven breast cancer cell growth through a complex, hierarchically organized network that initially involves suppression of the Hippo effector Yes-associated protein 1 (YAP1), which is followed by inhibition of AKT1 activity, increased FOXO3A activity as well as a blockade of FOXM1 and ERα expression. …”
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    RASSF1A Suppresses Estrogen-Dependent Breast Cancer Cell Growth through Inhibition of the Yes-Associated Protein 1 (YAP1), Inhibition of the Forkhead Box Protein M1 (FOXM1), and Activation of Forkhead Box Transcription Factor 3A (FOXO3A)
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